Journal of Ophthalmic and Vision Research
ISSN: 2008-322X
The latest research in clinical ophthalmology and vision science
Characterization of the Pre-lens Tear Film in Hydrogel and Silicone Hydrogel Contact Lens Wear
Published date: Sep 09 2025
Journal Title: Journal of Ophthalmic and Vision Research
Issue title: Volume 20 - 2025
Pages: 1 - 7
Authors:
Abstract:
Purpose: Different contact lens (CL) materials have been associated with different behaviors of pre-lens tear film components in the short term. The purpose of this randomized crossover and double-masked study was to compare the effect of wearing hydrogel and silicone hydrogel CLs on pre-lens tear film status.
Methods: Soft CL wearers were recruited and randomly fitted with a hydrogel (omafilcon A) and a silicone hydrogel (stenfilcon A) CL. Tear evaporation rate, non-invasive tear break-up time (NIBUT), tear film lipid layer thickness, and partial blink rate were measured without CLs and 30 minutes after the insertion of CLs. The outcomes were analyzed using repeated measures analysis of variance or the Friedman test.
Results: Twenty-four CL wearers (6 men and 18 women) aged 23.3 ± 3.9 years were included. Tear evaporation rate was higher with the hydrogel CL (98.6 ± 59.4 g/m2/h; P = 0.043) and the silicone hydrogel CL (99.7 ± 60.6 g/m2/h; P = 0.037) compared to no CL wear (69.9 ± 41.3 g/m2/h). NIBUT was lower (P = 0.019) with the silicone hydrogel CL (12.7 ± 6.2 s) than with no CL wear (18.5 ± 9.8 s). Lipid layer thickness was lower with the hydrogel CL (64.9 ± 15.5) than with the silicone hydrogel CL (75.8 ± 14.0; P < 0.001) and no CL wear (75.9 ± 14.2; P = 0.001). No statistically significant differences were found in the partial blink rate.
Conclusion: This study demonstrated that both hydrogel and silicone hydrogel CLs disrupt the tear film by increasing tear evaporation and causing tear film instability. However, CL materials affect the pre-lens tear film status differently. Further studies with longer wearing times are required.
Keywords: Hydrogel Contact Lens, Lipid Layer Thickness, Pre-Lens Tear Film, Tear Break-up Time, Tear Evaporation Rate
References:
1. Nichols JJ, King-Smith PE. Thickness of the pre- and postcontact lens tear film measured in vivo by interferometry. Invest Ophthalmol Vis Sci 2003;44:68–77.
2. Graham AD, Lin MC. The relationship of pre-corneal to precontact lens non-invasive tear breakup time. PLoS One 2021;16:e0247877.
3. Craig JP, Willcox MD, Argüeso P, Maissa C, Stahl U, Tomlinson A, et al.; members of TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: Report of the contact lens interactions with the tear film subcommittee. Invest Ophthalmol Vis Sci 2013;54:TFOS123-56.
4. Aragona P, Baudouin C, Benitez Del Castillo JM, Messmer E, Barabino S, Merayo-Lloves J, et al. The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders. Surv Ophthalmol 2021;66:907–925.
5. Fukui M, Yamada M, Akune Y, Shigeyasu C, Tsubota K. Fluorophotometric analysis of the ocular surface glycocalyx in soft contact lens wearers. Curr Eye Res 2016;41:9–14.
6. Pult H, Murphy PJ, Purslow C. A novel method to predict the dry eye symptoms in new contact lens wearers. Optom Vis Sci 2009;86:E1042–E1050.
7. Best N, Drury L, Wolffsohn JS. Predicting success with silicone-hydrogel contact lenses in new wearers. Cont Lens Anterior Eye 2013;36:232–237.
8. Glasson MJ, Stapleton F, Keay L, Sweeney D, Willcox MD. Differences in clinical parameters and tear film of tolerant and intolerant contact lens wearers. Invest Ophthalmol Vis Sci 2003;44:5116–5124.
9. Santodomingo-Rubido J, Wolffsohn JS, Gilmartin B. Changes in ocular physiology, tear film characteristics, and symptomatology with 18 months silicone hydrogel contact lens wear. Optom Vis Sci 2006;83:73–81.
10. King-Smith PE, Fink BA, Hill RM, Koelling KW, Tiffany JM. The thickness of the tear film. Curr Eye Res 2004;29:357– 368.
11. Talbott K, Xu A, Anderson DM, Seshaiyer P. Modelling the evaporation of a tear film over a contact lens. Math Med Biol 2015;32:209–238.
12. Siddireddy JS, Vijay AK, Tan J, Willcox M. The eyelids and tear film in contact lens discomfort. Cont Lens Anterior Eye 2018;41:144–153.
13. Rohit A, Ehrmann K, Naduvilath T, Willcox M, Stapleton F. Validating a new device for measuring tear evaporation rates. Ophthalmic Physiol Opt 2014;34:53–62.
14. Yang SN, Tai YC, Sheedy JE, Kinoshita B, Lampa M, Kern JR. Comparative effect of lens care solutions on blink rate, ocular discomfort and visual performance. Ophthalmic Physiol Opt 2012;32:412–420.
15. Collins MJ, Iskander DR, Saunders A, Hook S, Anthony E, Gillon R. Blinking patterns and corneal staining. Eye Contact Lens 2006;32:287–293.
16. Efron N, Jones L, Bron AJ, Knop E, Arita R, Barabino S, et al.; Members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: Report of the contact lens interactions with the ocular surface and adnexa subcommittee. Invest Ophthalmol Vis Sci 2013; 54:TFOS98–TFOS122.
17. Jones L, Brennan NA, González-Méijome J, Lally J, Maldonado-Codina C, Schmidt TA, et al.; Members of the TFOS International Workshop on Contact Lens Discomfort. The TFOS International Workshop on Contact Lens Discomfort: Report of the contact lens materials, design, and care subcommittee. Invest Ophthalmol Vis Sci 2013;54:TFOS37–TFOS70.
18. López-de la Rosa A, Martín-Montañez V, López-Miguel A, Fernández I, Calonge M, González-Méijome JM, et al. Ocular response to environmental variations in contact lens wearers. Ophthalmic Physiol Opt 2017;37:60–70.
19. Glasson MJ, Stapleton F, Keay L, Willcox MD. The effect of short term contact lens wear on the tear film and ocular surface characteristics of tolerant and intolerant wearers. Cont Lens Anterior Eye 2006;29:41–47.
20. Chalmers RL, Begley CG, Moody K, Hickson-Curran SB. Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) and opinion of contact lens performance. Optom Vis Sci 2012;89:1435–1442.
21. Thai LC, Tomlinson A, Doane MG. Effect of contact lens materials on tear physiology. Optom Vis Sci 2004;81:194– 204.
22. Hommel G. A stagewise rejective multiple test procedure based on a modified Bonferroni test. Biometrika 1988;75:383–386.
23. Morgan PB, Woods CA, Tranoudis IG, Helland M. International contact lens prescribing in 2014. Contact Lens Spectr 2015;30:28–33.
24. Morgan PB, Efron N. Quarter of a century of contact lens prescribing trends in the United Kingdom (1996–2020). Cont Lens Anterior Eye 2022;45:101446.
25. Morgan PB, Efron N. Global contact lens prescribing 2000- 2020. Clin Exp Optom 2022;105:298–312.
26. Arroyo CA, Byambajav M, Fernández I, Martin E, González- García MJ, López-Miguel A, et al. Diurnal variation on tear stability and correlation with tear cytokine concentration. Cont Lens Anterior Eye 2022;45:101705.
27. Llorens-Quintana C, Mousavi M, Szczesna-Iskander D, Iskander DR. Non-invasive pre-lens tear film assessment with high-speed videokeratoscopy. Cont Lens Anterior Eye 2018;41:18–22.
28. Montani G, Martino M. Tear film characteristics during wear of daily disposable contact lenses. Clin Ophthalmol 2020;14:1521–1531.
29. Tichenor AA, Cox SM, Ziemanski JF, Ngo W, Karpecki PM, Nichols KK, et al. Effect of the Bruder moist heat eye compress on contact lens discomfort in contact lens wearers: An open-label randomized clinical trial. Cont Lens Anterior Eye 2019;42:625–632.
30. Bai Y, Ngo W, Gu B, Zhang Y, Nichols JJ. An imaging system integrating optical coherence tomography and interferometry for in vivo measurement of the thickness and dynamics of the tear film. Biomed Eng Online 2018;17:164.
31. Vidal-Rohr M, Wolffsohn JS, Davies LN, Cerviño A. Effect of contact lens surface properties on comfort, tear stability and ocular physiology. Cont Lens Anterior Eye 2018;41:117– 121.
32. Jansen ME, Begley CG, Himebaugh NH, Port NL. Effect of contact lens wear and a near task on tear film break-up. Optom Vis Sci 2010;87:350–357.
33. Woods CA, Bentley SA, Fonn D. Temporal changes in contact lens comfort over a day of wear. Ophthalmic Physiol Opt 2016;36:643–648.
34. Novo-Diez A, Arroyo-Del Arroyo C, Blanco-Vázquez M, Fernández I, López-Miguel A, González-García MJ. Usefulness of a global rating change scale for contact lens discomfort evaluation. Cont Lens Anterior Eye 2021;44:101467.
35. Fernández I, López-Miguel A, Martín-Montañez V, Enríquez-de-Salamanca A, Calonge M, González-Méijome JM, et al. Inflammatory status predicts contact lens discomfort under adverse environmental conditions. Ocul Surf 2020;18:829–840.
