Journal of Ophthalmic and Vision Research

Published date: Sep 09 2025

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: ‎Volume 20 - 2025

Pages: 1 - 5

DOI: 10.18502/jovr.v20.16421

Kevin Eidkeid@oakland.eduOakland University William Beaumont School of Medicine, Rochester, MI

Shwetha Mudalegundishwetha.mudalegundi@hsc.utah.eduJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT

Melissa Yaomelissa.yao@hsc.utah.eduJohn A. Moran Eye Center, University of Utah, Salt Lake City, UT

Alen Eidaeid@gmail.comWest Virginia University Eye Institute, Morgantown, WV

Matthew Szarkomszarko@gmail.comWest Virginia University Medicine Ruby Memorial Hospital, Morgantown, WV

John Nguyennguyenj@wvumedicine.orgWest Virginia University Eye Institute, Morgantown, WV

Purpose: Leiomyosarcoma (LMS) is an aggressive tumor with a high metastatic rate that rarely metastasizes to the periocular region.

Case Report: A 50-year-old male with a previous two-year history of primary stage IV LMS presented with metastatic retroperitoneal LMS, which was initially incorrectly described as an eyelid chalazion refractory to medical management. An excisional biopsy sent to pathology revealed metastatic retroperitoneum LMS. There was resolution of ocular irritation following biopsy, and an oncology referral was made.

Conclusion: This case of metastatic LMS to the eyelid mimicking a chalazion is rare, as only six other cases have been described previously. Our case contributes to this discussion by highlighting the importance of considering metastatic disease and performing a full-thickness biopsy in a patient presenting with a non-resolving eyelid chalazion. Recognizing tumor spread to the eyelid can be an important step in the diagnosis, surveillance, and management of metastatic LMS.

Keywords: Chalazion, Eyelid, Leiomyosarcoma, Metastatic, Oculoplastic Surgery

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