Journal of Ophthalmic and Vision Research

Published date: Oct 22 2025

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: ‎Volume 20 - 2025

Pages: 1 - 7

DOI: 10.18502/jovr.v20.11524

Aluisio Rosa Gameiro Filhoaluisio.gameiro@unifesp.brOphthalmology and Visual Sciences Department, Universidade Federal de São Paulo, Escola Paulista de Medicina (Unifesp – EPM), São Paulo - SP

Rafael Godoyrafaelgodoy@hotmail.comMédicos de Olhos SA, Rua Benjamin Lins, 790 - Batel, Curitiba - PR

Flávio Mac Cord Medinafmaccord@yahoo.com.brHospital Federal dos Servidores do Estado do Rio de Janeiro, Rua Sacadura Cabral, 178 - Saúde, Rio de Janeiro - RJ

Patrícia Correa de Mello Araújopcorrea@globo.comHospital Federal dos Servidores do Estado do Rio de Janeiro, Rua Sacadura Cabral, 178 - Saúde, Rio de Janeiro - RJ

Melina Correia Moralesmmorales@yahoo.com.brOphthalmology and Visual Sciences Department, Universidade Federal de São Paulo, Escola Paulista de Medicina (Unifesp – EPM), São Paulo - SP

Rubens N Belfortrubens@belfort.med.comOphthalmology and Visual Sciences Department, Universidade Federal de São Paulo, Escola Paulista de Medicina (Unifesp – EPM), São Paulo - SP

Purpose: To present a case of bilateral diffuse uveal melanocytic proliferation (BDUMP), which is a rare paraneoplastic syndrome that causes progressive visual loss in patients with an underlying malignancy.

Case Report: A 59-year-old female patient presented with bilateral visual loss, which had started three months earlier. She had a history of treated ovarian cancer a year before. Fundus examination showed multiple red-orange subretinal patches with irregular and elevated pigmented tumors in both eyes, scattered over the fundus. Multimodal imaging was also consistent with BDUMP. She was referred to a clinical oncologist and underwent screening for systemic metastasis, which revealed multiple foci of secondary malignancies.

Conclusion: Ophthalmologists should be aware of this extremely rare condition. Although there is currently no effective treatment for ocular symptoms, the patient should be promptly referred to an oncologist for systemic screening and potential treatment of the primary site malignancy.

Keywords: Bilateral Diffuse Uveal Melanocytic Proliferation, Paraneoplastic Syndrome, Melanocytes, Malignancy, Ocular Oncology, Ovarian Cancer

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