Journal of Infertility and Reproductive Biology

Published date: Mar 20 2025

Journal Title: Journal of Infertility and Reproductive Biology

Issue title: Journal of Infertility and Reproductive Biology: Volume 13, Issue 1

Pages: 4 - 26

DOI: 10.18502/jirb.v13i1.18766

Kimia GoudarziSchool of Medicine, Shiraz University of Medical Sciences, Shiraz

Jahangir KamalpourSchool of Medicine, Shiraz University of Medical Sciences, Shiraz

Saghar ZekriDepartment of Cell Biology, Faculty of Arts and Science, University of Toronto, Toronto

Raisa A. AringazinaDepartment of Internal Diseases No. 1, Non-Commercial joint-stock Society “West Kazakhstan Marat Ospanov Medical University”, Aktobe

Ramazon Sharofiddin SafarzodaEducational, scientific, and production center “Pharmacy”, Avicenna Tajik State Medical University, Dushanbe

Amin Tamadonamintamaddon@yahoo.comDepartment of Natural Sciences, West Kazakhstan Marat Ospanov Medical University, Aktobe

Nader Tanidehtanidehn@sums.ac.irStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz

Polycystic ovary syndrome (PCOS) represents one of the most common endocrine disorders affecting women of reproductive age, serving as a major contributor to infertility on a global scale, with an estimated prevalence varying from 6 to 20% worldwide. PCOS is a complex syndrome defined by hyperandrogenism, irregular ovulation, and the presence of polycystic ovarian morphology. This syndrome is often associated with metabolic complications, including obesity, dyslipidemia, and an elevated risk of insulin resistance and developing type 2 diabetes. Symptoms include menstrual irregularities, weight gain, hirsutism, acne, and infertility. The presently available conventional treatment options for PCOS include hormonal contraceptives, insulin sensitizers, anti-androgens, and ovulation-inducing agents. While these treatments may offer symptomatic relief, they often entail potential side effects and do not adequately address the underlying cause of this syndrome. Herbal remedies have been used for centuries across cultures to manage various disorders due to their cost efficiency, availability, and safe nature. Several studies have demonstrated the efficiency of herbal remedies in the treatment of female reproductive disorders, including PCOS. This review comprises an extensive survey of the latest animal and clinical studies concerning plants and phytochemicals that have demonstrated effectiveness in alleviating symptoms associated with PCOS, as well as treating the underlying mechanisms involved in their efficacy

Keywords: herbal medicine, infertility, oxidative stress, polycystic ovary syndrome, phytochemical

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