Journal of Ophthalmic and Vision Research

Published date: Aug 27 2025

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: ‎Volume 20 - 2025

Pages: 1 - 6

DOI: 10.18502/jovr.v20.16399

Ozlem Barut Selverozlembarutselver@gmail.comDepartment of Ophthalmology, Ege University Faculty of Medicine, Izmir

Emil Ahmadliemil_466@mail.ruDepartment of Ophthalmology, Ege University Faculty of Medicine, Izmir

Muhammed Dara Tasdaratas62@gmail.comDepartment of Ophthalmology, Ege University Faculty of Medicine, Izmir

Banu Yamanbanu.yaman@ege.deu.trDepartment of Pathology, Ege University Faculty of Medicine, Izmir

Naim Ceylannaim.ceylan@ege.edu.trDepartment of Radiology, Ege University Faculty of Medicine, Izmir

Mozhgan Rezaei Kanavi daratas00@hotmail.conOcular Tissue Engineering Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran

Purpose: To report a case of eosinophilic granulomatosis with polyangiitis (EGPA) initially presenting as orbital involvement, describe its successful management, and provide a comprehensive literature review.
Case Report: A 33-year-old female patient presented with swelling, redness, tenderness, and a mass under the left upper eyelid for one month. Upper lid eversion showed a multilobulated lesion in the subconjunctival area of the same region. The patient’s medical history included asthma and atrial septal defect surgery. Orbital MRI revealed a soft tissue mass infiltrating the superior and lateral aspects of the conal and extraconal regions in the anterior orbit, with extension toward the preseptal area. The lesion underwent incisional biopsy, and histopathological findings were consistent with the diagnosis of EGPA. The patient’s blood tests revealed eosinophilia and a negative antineutrophil cytoplasmic antibody. After excluding other similar pathologies such as granulomatosis with polyangiitis, we observed a dramatic regression in her orbital lesion following systemic steroid therapy.
Conclusion: The diagnosis of EGPA, a rare clinical presentation, is crucial for ophthalmologists because it provides early recognition of the systemic disease and can help slow its progression by initiating appropriate treatment in a timely manner.

Keywords: Antineutrophil Cytoplasmic Antibody, Eosinophilia, Eosinophilic Granulomatosis with Polyangiitis, Orbit, Systemic Steroid

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