Journal of Ophthalmic and Vision Research
ISSN: 2008-322X
The latest research in clinical ophthalmology and vision science
Refractive Profile and Angle of Deviation in Patients with Congenital Esotropia and Congenital Exotropia:
Published date: Jun 13 2025
Journal Title: Journal of Ophthalmic and Vision Research
Issue title: Volume 20 - 2025
Pages: 1 - 9
Authors:
Abstract:
Purpose: To compare refractive error and angle of deviation in patients with congenital esotropia (CET) and congenital exotropia (CXT).
Methods: This retrospective study reviewed the medical documents of 246 patients with CET (n = 206) and CXT (n = 40) admitted to Farabi Eye Hospital, Iran, from 2012 to 2022. All patients were between 6 and 12 months old at the time of admission. Refractive error components and angles of deviation in these patients were recorded and analyzed.
Results: In patients with CET, the mean sphere, cylinder, and spherical equivalent (SE) were 2.59 ± 2.28 diopters (D), –0.42 ± 0.57 D, and 2.38 ± 2.28 D, respectively. Also, the mean horizontal deviation at near was 45.5 ± 12.3 prism diopters (Δ) (range, 20–98 Δ). The most common range was 44–55 Δ (40%), followed by 33–44 Δ (28%) and 55–65 Δ (12%). On the other hand, the mean sphere, cylinder, and SE in patients with CXT were 1.88 ± 1.84 D, –0.39 ± 0.69 D, and 1.69 ± 1.74 D, respectively. Also, the mean horizontal deviation at near was 45.0 ± 17.1 Δ (range, 20–105 Δ). For the CXT group, deviation ranges of 33–44 Δ (37%), 44–55 Δ (32%), and 22–33 Δ (15%) were most prevalent. The mean sphere and SE were significantly higher in the CET group than in the CXT group (P = 0.010).
Conclusion: This study found a distinct refractive profile and distribution of the angle of deviation in patients with CET versus CXT. Patients with CET demonstrated significantly greater hyperopia than those with CXT.
Keywords: Angle of Deviation, Congenital Esotropia, Congenital Exotropia, Refractive Error
References:
1. Robaei D, Rose KA, Kifley A, Cosstick M, Ip JM, Mitchell P. Factors associated with childhood strabismus: Findings from a population-based study. Ophthalmology 2006;113:1146–1153.
2. Buffenn AN. The impact of strabismus on psychosocial health and quality of life: A systematic review. Surv Ophthalmol 2021;66:1051–1064.
3. Mohney BG, Erie JC, Hodge DO, Jacobsen SJ. Congenital esotropia in Olmsted County, Minnesota. Ophthalmology 1998;105:846–850.
4. He H, Fu J, Meng Z, Chen W, Li L, Zhao X. Prevalence and associated risk factors for childhood strabismus in Lhasa, Tibet, China: A cross-sectional, school-based study. BMC Ophthalmol 2020;20:463.
5. von Noorden GK. A reassessment of infantile esotropia. XLIV Edward Jackson memorial lecture. Am J Ophthalmol 1988;105:1–10.
6. Parks MM. Abnormal accommodative convergence in squint. AMA Arch Opthalmol 1958;59:364–380.
7. Birch EE, Stager DR. Monocular acuity and stereopsis in infantile esotropia. Invest Ophthalmol Vis Sci 1985;26:1624–1630.
8. Birch EE, Stager DR, Berry P, Everett ME. Prospective assessment of acuity and stereopsis in amblyopic infantile esotropes following early surgery. Invest Ophthalmol Vis Sci 1990;31:758–765.
9. Arnold RW, Strominger MB, Vagge A, Nelson LB. Management of congenital esotropia. J Pediatr Ophthalmol Strabismus 2023;60:310–311.
10. Maconachie GD, Gottlob I, McLean RJ. Risk factors and genetics in common comitant strabismus: A systematic review of the literature. JAMA Ophthalmol 2013;131:1179–1186.
11. Mohney BG. Common forms of childhood strabismus in an incidence cohort. Am J Ophthalmol 2007;144:465–467.
12. Rogers GL, Chazan S, Fellows R, Tsou BH. Strabismus surgery and its effect upon infant development in congenital esotropia. Ophthalmology 1982;89:479–483.
13. Keenan JM, Willshaw HE. Outcome of strabismus surgery in congenital esotropia. Br J Ophthalmol 1992;76:342–345.
14. Vroman DT, Hutchinson AK, Saunders RA, Wilson ME. Two-muscle surgery for congenital esotropia: Rate of reoperation in patients with small versus large angles of deviation. J AAPOS 2000;4:267–270.
15. Wan MJ, Chiu H, Shah AS, Hunter DG. Long-term surgical outcomes for large-angle infantile esotropia. Am J Ophthalmol 2018;189:155–159.
16. Gezer A, Sezen F, Nasri N, Gözüm N. Factors influencing the outcome of strabismus surgery in patients with exotropia. J AAPOS 2004;8:56–60.
17. Faridi UA, Saleh TA, Ewings P, Twomey JM. Factors affecting the surgical outcome of primary exotropia. Strabismus 2007;15:127–131.
18. Lajmi H, El Fekih L, Khlifi K, Wassim H. Infantile Esoropia: Management results and prognostic factors. Tunis Med 2021;99:1180–1187.
19. Hiles DA, Watson BA, Biglan AW. Characteristics of infantile esotropia following early bimedial rectus recession. Arch Ophthalmol 1980;98:697–703.
20. Birch EE, Stager DR Sr, Wang J, O’Connor A. Longitudinal changes in refractive error of children with infantile esotropia. Eye 2010;24:1814–1821.
21. Williams F, Beneish R, Polomeno RC, Little JM. Congenital exotropia. Am Orthopt J 1984;34:92–94.
22. Olson JH, Louwagie CR, Diehl NN, Mohney BG. Congenital esotropia and the risk of mental illness by early adulthood. Ophthalmology 2012;119:145–149.
23. Wright KW. Exotropia. Wright KW. Pediatric ophthalmology and strabismus St Louis. Mosby; 1995. pp. 195–202.24. von Noorden GK. Exodeviations. In: von Noorden GK, eds. Binocular vision and ocular motility: Theory and management of strabismus. 6th ed. St Louis: Mosby; 2002. pp. 356–376.
25. Mohney BG, Huffaker RK. Common forms of childhood exotropia. Ophthalmology 2003;110:2093–1096.
26. Sheeladevi S, Seelam B, Nukella PB, Borah RR, Ali R, Keay L. Prevalence of refractive errors, uncorrected refractive error, and presbyopia in adults in India: A systematic review. Indian J Ophthalmol 2019;67:583–592.
27. Akbari MR, Jafari A. The prevalence of refractive errors and binocular anomalies in students of deaf boys schools in Tehran. J Curr Ophthalmol 2014;26:183.
28. Panel SP, Sprunger DT, Lambert SR, Hercinovic A, Morse CL, Repka MX, et al. Pediatric ophthalmology/strabismus preferred practice pattern development process and participants. Ophthalmology 2023;130:179.
29. Masoomian B, Akbari MR, Mirmohamadsadeghi A, Aghsaei Fard M, Khorrami-Nejad M, Hamad N, et al. Clinical characteristics and surgical approach in Duane retraction syndrome: A study of 691 patients. Jpn J Ophthalmol 2022;66:474–480.
30. Akbari MR, Khorrami-Nejad M, Kangari H, Akbarzadeh Baghban A, Ranjbar Pazouki M. Ocular abnormal head posture: A literature review. J Curr Ophthalmol 2022;33:379–387.
31. Merino P, Gómez de Liaño P, Villalobo JM, Franco G, Gómez de Liaño R. Etiology and treatment of pediatric sixth nerve palsy. J AAPOS 2010;14:502–505.
32. Choi RY, Kushner BJ. The accuracy of experienced strabismologists using the Hirschberg and Krimsky tests. Ophthalmology 1998;105:1301–1306.
33. Riddell PM, Hainline L, Abramov I. Calibration of the Hirschberg test in human infants. Invest Ophthalmol Vis Sci 1994;35:538–543.
34. Saunders KJ, Woodhouse JM, Westall CA. Emmetropisation in human infancy: Rate of change is related to initial refractive error. Vision Res 1995;35:1325–1328.
35. Burian HM. Hypermetropia and esotropia. J Pediatr Ophthalmol Strabismus 1972;9:135.
36. Atkinson J, Braddick O, Robier B, Anker S, Ehrlich D, King J, et al. Two infant vision screening programmes: Prediction and prevention of strabismus and amblyopia from photoand videorefractive screening. Eye 1996;10:189–198.
37. Von Noorden GK. Burian-von Noorden’s Binocular vision and ocular motility: Theory and management of strabismus. Mosby; 1985.
38. Costenbader FD. Infantile esotropia. Trans Am Ophthalmol Soc 1961;59:397–429.
39. Taylor DM. How early is early surgery in the management of strabismus? Arch Ophthalmol 1963;70:752–756.
40. Ing MR. Early surgical alignment for congenital esotropia. NJ: SLACK Incorporated Thorofare; 1983. pp. 11–18.
41. Ing MR. Outcome study of surgical alignment before six months of age for congenital esotropia. Ophthalmology 1995;102:2041–2045.