West Kazakhstan Medical Journal

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Pulp Necrosis Treatment: Evaluating the Effectiveness of Stem Cell Therapy: A Minireview

Published date: Jun 02 2025

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 67 Issue 2

Pages: 150 - 161

DOI: 10.18502/wkmj.v67i2.17125

Authors:

Madina A. Kurmanalinamadina83203@gmail.comDepartment of Therapeutic and Prosthetic Dentistry, West Kazakhstan Marat Ospanov Medical University, Aktobe

Ihtesham ur RehmanIURehman@uclan.ac.ukProfessor of Biomaterials and Regenerative Medicine, School of Medicine and Dentistry, University of Central Lancashire, Preston

Aigul M. Sumanovasumanova1@mail.ruDepartment of Therapeutic and Surgical Dentistry, Astana Medical University, Astana

Zhanara A. ShabanbayevaShabanbayeva77@mail.ruDepartment of Therapeutic and Surgical Dentistry, Astana Medical University, Astana

Abstract:

Pulp necrosis, a prevalent condition in endodontics, poses significant challenges in preserving tooth vitality and function. Traditional treatment methods like root canal therapy often focus on managing symptoms and controlling the infection rather than promoting natural tissue regeneration. This article evaluates the effectiveness of stem cell therapy as an innovative approach to treating pulp necrosis. We review recent advancements and clinical trials that explore the regenerative potential of stem cells, including mesenchymal stem cells (MSCs), from various sources. The review highlights the underlying mechanisms of stem cell therapy, such as differentiation and angiogenesis, and compares these to conventional methods in terms of efficacy and patient outcomes. By examining the current state of research, challenges, and future directions, this article aims to provide a comprehensive understanding of how stem cell therapy could revolutionize the treatment of pulp necrosis and improve clinical practice.

Keywords: pulp necrosis, stem cell therapy, mesenchymal stem cells, regenerative endodontics, tooth vitality, angiogenesis

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