West Kazakhstan Medical Journal

Published date: Mar 25 2025

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 67 Issue 1

Pages: 123 - 131

DOI: 10.18502/wkmj.v67i1.16911

Saule Akhmetova Zhumabaevnasaule_7018@mail.ruDepartment of Pathological Anatomy and Forensic Medicine, WKMU State M. Ospanov, Aktobe

Abdiraman Kaliev Rsalievichbalam.63@mail.ruDepartment of Pathological Anatomy and Forensic Medicine, WKMU State M. Ospanov, Aktobe

Anarzhan Tulyaeva Balkashevnadekart_85@mail.ruOncology Department, WKMU State M. Ospanov, Aktobe

Aigul Ramankulova Bulatovnaramankulova1977@mail.ruDepartment of Pathological Anatomy and Forensic Medicine, WKMU State M. Ospanov, Aktobe

Talshyn Nurulla Amirkhanqyzytalshynurulla@mail.ruDepartment of Pathological Anatomy and Forensic Medicine, WKMU State M. Ospanov, Aktobe

Nurbek Azbergenov Kozhakhmetovichdr.pathologist@mail.ruDepartment of Pathological Anatomy and Forensic Medicine, WKMU State M. Ospanov, Aktobe

Nurgul Kereeva Meirimovnanrgl77@mail.ruOncology Department, WKMU State M. Ospanov, Aktobe

Sergei Chukov Zalimovichchukov@mail.ruDepartment of Pathological Anatomy, Stavropol State Medical Academy, Stavropol

Helicobacter pylori - causes pathologies such as gastritis, peptic ulcer disease, adenocarcinoma. Pseudopyloric mucosal metaplasia in the incisura region is significantly correlated with the development of precancerous changes - atrophy and intestinal metaplasia. Pseudopyloric metaplasia of the gastric mucosa develops as a result of persistence of H. pylori infection. Immunohistochemical and histological study of gastric mucosa biopsy specimens from patients with dyspeptic complaints was performed. Chronic non-atrophic gastritis was histologically detected in 21 patients. Of these, 17 (80.95%) were H. pylori-positive. Out of 55 patients with chronic atrophic gastritis, 38 (69.1%) were H. pylori-positive. Ki-67 IM was significantly increased during the development of atrophic gastritis: in the antral region to 50.6±8.3 (P<0.05), in atrophy and pseudopyloric metaplasia in the incisura region to an average of 47.3±8.2 (P<0.05) and in the gastric body region to an average of 46.9±7.4 (P<0.05). In chronic atrophic gastritis, p53 expression was detected in the antral region in 22 (40.0%) patients, and in atrophy and pseudopyloric metaplasia in the incisura region in 18 (50.0%) and in the body in 4 (57.1%). All patients were H. pylori-positive. Intestinal metaplasia was found in 36 (65.5%) patients in the antral region, 34 (61.8%) patients in the incisura region and 24 (43.6%) patients in the body of the stomach This study showed that in chronic H. pylori-associated atrophic gastritis there is an acceleration of cell proliferation and impaired apoptosis, especially in areas of atrophy, as well as pseudopyloric and intestinal epithelial metaplasia, leading to an increased risk of gastric cancer.

Keywords: H. pylori, atrophy, metaplasia, proliferation, stomach cancer

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