Published date: Jun 28 2024

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 66 Issue 2

Pages: 119–125

DOI: 10.18502/wkmj.v66i2.16454

Aditi Singh Chouhanchouhanaditisingh2001@gmail.comGovernment Medical Hospital, Chittorgarh, Rajasthan, India,

Rithish BharadwajInternational Medical Graduate West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Madhup BaxiDepartment of Internal Medicine, MP Birla Hospital and Research Centre, Chittorgarh, Rajasthan, India

Aliya ZhylkybekovaDepartment of Pathological Physiology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Cancer remains a significant global health challenge, with increasing mortality rates. Despite advancements in conventional treatments, the exploration of alternative therapies remains vital. This study investigates the antioxidant properties of Datura in treatment of cancer disease. We searched three electronic databases: PubMed, Scopus, and Web of Science. Datura herb possesses antioxidant properties due to phytochemical compounds like phytol acetate, beta-damascenone, and betaeudesmol, which scavenge free radicals and reduce nitric oxide production. Additionally, it exhibits anti-inflammatory effects by augmenting pro-inflammatory cytokine secretion and enhancing lymphocyte cytotoxic activity against cancer cells. Moreover, Datura’s anticancer potential lies in its ability to inhibit cellular signaling pathways involved in cancer development, particularly in breast and lung cancers by compounds like alkaloids, tannins, flavonoids, and cardiac glycoside. However, it is crucial to acknowledge the herb’s toxicity, which can cause severe central nervous system damage, hallucinations, and even death at high doses, necessitating careful extraction and evaluation of its compounds for therapeutic use.

Keywords: Datura stramonium, Datura inoxia, cancer, free radicals, antioxidant

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