Published date: Jun 28 2024

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 66 Issue 2

Pages: 111–118

DOI: 10.18502/wkmj.v66i2.16453

Nurgul Ablakimovan.ablakimova@zkmu.kzDepartment of Pharmacology, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

This review explores the transformative impact of rapid diagnostic tests (RDTs) on pneumonia management. Pneumonia, a global health challenge, often requires swift identification of causative pathogens for effective treatment. Traditional diagnostic methods, while valuable, have limitations, prompting the rise of RDTs. The review highlights the advantages, challenges, and future directions of RDTs, emphasizing their potential to provide real-time pathogen identification, improve treatment strategies, and enhance patient care in the context of pneumonia.

Keywords: pneumonia, pathogen, antibiotic resistance, global health, diagnostics

[1] Watkins K, Sridhar D. Pneumonia: a global cause without champions. The Lancet. 2018;392(10149):718-9.

[2] Lopardo GD, Fridman D, Raimondo E, Albornoz H, Lopardo A, Bagnulo H, et al. Incidence rate of community-acquired pneumonia in adults: A population-based prospective active surveillance study in three cities in South America. BMJ open. 2018;8(4):e019439.

[3] Lanks CW, Musani AI, Hsia DW. Community-acquired pneumonia and hospital-acquired pneumonia. Medical Clinics. 2019;103(3):487-501.

[4] van der Eerden MM, Vlaspolder F, de Graaff CS, Groot T, Jansen HM, Boersma WG. Value of intensive diagnostic microbiological investigation in low- and high-risk patients with communityacquired pneumonia. Eur J Clin Microbiol Infect Dis. 2005;24(4):241-9.

[5] Uematsu H, Hashimoto H, Iwamoto T, Horiguchi H, Yasunaga H. Impact of guideline-concordant microbiological testing on outcomes of pneumonia. Int J Qual Health Care. 2013;26(1):100-7.

[6] Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, et al. Infectious diseases society of America/American thoracic society consensus guidelines on the management ofcommunity-acquired pneumonia in adults. Clin Infect Dis. 2007;44(Supplement_2):S27-S72.

[7] Nakajima M, Umezaki Y, Takeda S, Yamaguchi M, Suzuki N, Yoneda M, et al. Association between oral candidiasis and bacterial pneumonia: A retrospective study. Oral Dis. 2019;26(1):234-7.

[8] Zhang D, Yang D, Makam AN. Utility of blood cultures in pneumonia. The Am J Med. 2019;132(10):1233-8.

[9] Musher DM, Montoya R, Wanahita A. Diagnostic value of microscopic examination of Gram-stained sputum and sputum cultures in patients with bacteremic pneumococcal pneumonia. Clin Infect Dis. 2004;39(2):165-9.

[10] Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, et al. Diagnostic value of blood parameters for community-acquired pneumonia. Int immunopharmacol. 2018;64:10-5.

[11] Miyashita N, Kawai Y, Yamaguchi T, Ouchi K, Oka M, Group APS. Clinical potential of diagnostic methods for the rapid diagnosis of mycoplasma pneumoniae pneumonia in adults. Eur J Clin Microbiol Infect Dis. 2011;30:439-46.

[12] Niederman MS. Imaging for the management of community-acquired pneumonia: What to do if the chest radiograph is clear. Chest. 2018;153(3):583-5.

[13] Johansson N, Kalin M, Tiveljung-Lindell A, Giske CG, Hedlund J. Etiology of community-acquired pneumonia: Increased microbiological yield with new diagnostic methods. Clin Infect Dis. 2010;50(2):202- 9.

[14] Le Dorze M, Gault N, Foucrier A, Ruppé E, Mourvillier B, Woerther P, et al. Performance and impact of a rapid method combining mass spectrometry and direct antimicrobial susceptibility testing on treatment adequacy of patients with ventilatorassociated pneumonia. Clin Microbiol and Infect. 2015;21(5):468. e1-. e6.

[15] Monard C, Pehlivan J, Auger G, Alviset S, Tran Dinh A, Duquaire P, et al. Multicenter evaluation of a syndromic rapid multiplex PCR test for early adaptation of antimicrobial therapy in adult patients with pneumonia. Critical Care. 2020;24(1):434.

[16] Sinclair A, Xie X, Teltscher M, Dendukuri N. Systematic review and meta-analysis of a urine-based pneumococcal antigen test for diagnosis of communityacquired pneumonia caused by Streptococcus pneumoniae. J Clin Microbiol. 2013;51(7):2303-10.

[17] Couturier MR, Graf EH, Griffin AT. Urine antigen tests for the diagnosis of respiratory infections: legionellosis, histoplasmosis, pneumococcal pneumonia. Clin Lab Med. 2014;34(2):219-36.

[18] File TM, Jr. New diagnostic tests for pneumonia: What is their role in clinical practice? Clin Chest Med. 2011;32(3):417-30.

[19] Shimada T, Noguchi Y, Jackson JL, Miyashita J, Hayashino Y, Kamiya T, et al. Systematic review and metaanalysis: Urinary antigen tests for Legionellosis. Chest. 2009;136(6):1576-85.

[20] Fields BS, Benson RF, Besser RE. Legionella and Legionnaires’ disease: 25 years of investigation. Clin Microbiol Rev. 2002;15(3):506-26.

[21] Smith MD, Derrington P, Evans R, Creek M, Morris R, Dance DA, et al. Rapid diagnosis of bacteremic pneumococcal infections in adults by using the Binax NOW Streptococcus pneumoniae urinary antigen test: a prospective, controlled clinical evaluation. J Clin Microbiol. 2003;41(7):2810-3.

[22] Selickman J, Paxos M, File Jr TM, Seltzer R, Bonilla H. Performance measure of urinary antigen in patients with Streptococcus pneumoniae bacteremia. Diagn Microbiol Infect Dis. 2010;67(2):129-33.

[23] Samra Z, Shmuely H, Nahum E, Paghis D, Ben-Ari J. Use of the NOW Streptococcus pneumoniae urinary antigen test in cerebrospinal fluid for rapid diagnosis of pneumococcal meningitis. Diagn Microbiol Infect Dis. 2003;45(4):237-40.

[24] Viasus D, Calatayud L, McBrown MV, Ardanuy C, Carratalà J. Urinary antigen testing in communityacquired pneumonia in adults: An update. Expert RevAnti Infect Ther. 2019;17(2):107-15

[25] Bellew S, Grijalva CG, Williams DJ, Anderson EJ, Wunderink RG, Zhu Y, et al. Pneumococcal and Legionella urinary antigen tests in communityacquired pneumonia: Prospective evaluation of indications for testing. Clin Infect Dis. 2019;68(12):2026- 33.