Published date: Sep 26 2024

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 66 Issue 3

Pages: 210–238

DOI: 10.18502/wkmj.v66i3.15772

Pardis Shirkanipardisshirkani@yahoo.comDepartment of Science, University of British Columbia, Vancouver, British Columbia V6T 1Z4

Afshin Shirkania.shirkani@bpums.ac.irAllergy and Clinical Immunology Department, Bushehr University of Medical Science, School of Medicine, Bushehr

This paper examines the impact of global warming on cancer development, specifically focusing on the intensified effects of environmental carcinogens such as ultraviolet (UV) radiation and air pollutants. Our review elucidates the intricate interplay between global warming, ecological carcinogens, human immunogenetics, and cancer susceptibility. The analysis highlights the exacerbating effects of rising temperatures and changes in atmospheric conditions on exposure to UV radiation and air pollutants, including particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), nitrogen dioxide (NO₂), nitrogen oxides (NOx), and ground-level ozone (O₃). Furthermore, the study explores the pivotal role of human immunogenetics in modulating individual responses to carcinogen exposure and shaping cancer susceptibility and progression. Genetic variations in key immune-related genes and their influence on the interplay between environmental carcinogens and cancer development are discussed. The paper underscores the importance of longitudinal cohort studies, integrative approaches, and interdisciplinary collaborations to advance our understanding of the complex interactions between global warming, environmental carcinogens, human immunogenetics, and cancer biology. Additionally, evidence-based public health interventions targeting environmental carcinogens and personalized prevention strategies based on genetic susceptibility profiles and environmental exposure assessments are proposed to address the growing challenges of environmentally induced cancers.

Keywords: global warming, environmental carcinogens, cancer immunogenetics, ultraviolet radiation, air pollutants, genetic susceptibility

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