Published date:Dec 21 2023

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 65 Issue 4

Pages:79 - 87

DOI: 10.18502/wkmj.v65i4.14683

Akmaral Baspakovabaspakova@zkgmu.kzDepartment for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Kulyash R. ZhilisbayevaDepartment for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Aigerim A. UmbetovaDepartment for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

Anara Zh. AbitovaDepartment for Scientific Work, West Kazakhstan Marat Ospanov Medical University, Aktobe, Kazakhstan

The present mini review delves into the intricate nexus between processed foods and gut health, with a focused exploration of the dynamic responses exhibited by the gut microbiome. The ubiquity of processed foods in contemporary diets has prompted inquiries into their potential ramifications for human physiological well-being. Given the acknowledged centrality of the gut microbiota in sustaining holistic health, deciphering the nuances of how processed foods impinge upon its constitution and functionality assumes critical significance. By methodically scrutinizing recent empirical investigations, this mini review elucidates the multifaceted manners through which processed foods interface with the complex web of the gut microbial consortium. It meticulously delineates alterations in microbial taxonomic diversity, community richness, and ecological equilibrium, thereby elucidating the putative mechanistic underpinnings driving the possible impact of processed food consumption on physiological equilibrium. Furthermore, the review cogitates upon the broader translational repercussions of these microbiome perturbations, cogently contemplating potential correlations with pathophysiologies encompassing but not limited to inflammation cascades, metabolic perturbations, and immune homeostasis dysregulation. By synthesizing the current compendium of empirical insights, this mini review proffers cogent perspectives into the intricate interplay between processed foods and gut health. It substantiates the exigency for augmented investigative endeavors, whilst advocating for judicious dietary selections that foster resilience and equilibrium within the intricate milieu of the gut microbiome.

Keywords: ultra-processed foods, NOVA, microbiota, intestines, feeding behavior

[1] Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra-processed products are becoming dominant in the global food system. Obes Rev. 2013;14 Suppl 2:21-8.

[2] Trakman GL, Fehily S, Basnayake C, Hamilton AL, Russell E, Wilson-O’Brien A, et al. Diet and gut microbiome in gastrointestinal disease. J Gastroenterol Hepatol. 2022;37(2):237-45.

[3] Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Minireview: Gut microbiota: the neglected endocrine organ. Mol Endocrinol. 2014;28(8):1221-38.

[4] Nova E, Gómez-Martinez S, González-Soltero R. The Influence of Dietary Factors on the Gut Microbiota. Microorganisms. 2022;10(7).

[5] Faisal-Cury A, Leite MA, Escuder MML, Levy RB, Peres MFT. The relationship between ultra-processed food consumption and internalising symptoms among adolescents from São Paulo city, Southeast Brazil. Public Health Nutr. 2022;25(9):2498-506.

[6] Fardet A, Rock E. Ultra-Processed Foods and Food System Sustainability: What Are the Links? Sustainability. 2020;12(15):6280.

[7] de Araújo TP, de Moraes MM, Afonso C, Santos C, Rodrigues SSP. Food Processing: Comparison of Different Food Classification Systems. Nutrients. 2022;14(4).

[8] Martini D, Godos J, Bonaccio M, Vitaglione P, Grosso G. Ultra-Processed Foods and Nutritional Dietary Profile: A Meta-Analysis of Nationally Representative Samples. Nutrients. 2021;13(10).

[9] Wiertsema SP, van Bergenhenegouwen J, Garssen J, Knippels LMJ. The Interplay between the Gut Microbiome and the Immune System in the Context of Infectious Diseases throughout Life and the Role of Nutrition in Optimizing Treatment Strategies. Nutrients. 2021;13(3).

[10] Leeming ER, Johnson AJ, Spector TD, Le Roy CI. Effect of Diet on the Gut Microbiota: Rethinking Intervention Duration. Nutrients. 2019;11(12).

[11] Khoshbin K, Camilleri M. Effects of dietary components on intestinal permeability in health and disease. Am J Physiol Gastrointest Liver Physiol. 2020;319(5):G589- g608.

[12] Inczefi O, Bacsur P, Resál T, Keresztes C, Molnár T. The Influence of Nutrition on Intestinal Permeability and the Microbiome in Health and Disease. Front Nutr. 2022;9:718710.

[13] Yan J, Wang L, Gu Y, Hou H, Liu T, Ding Y, et al. Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges. Nutrients. 2022;14(19).

[14] Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease. Expert Rev Gastroenterol Hepatol. 2017;11(9):821-34.

[15] Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-30.

[16] Yin R, Kuo HC, Hudlikar R, Sargsyan D, Li S, Wang L, et al. Gut microbiota, dietary phytochemicals and benefits to human health. Curr Pharmacol Rep. 2019;5:332-44.

[17] Su Q, Liu Q. Factors Affecting Gut Microbiome in Daily Diet. Front Nutr. 2021;8:644138.

[18] González Olmo BM, Butler MJ, Barrientos RM. Evolution of the Human Diet and Its Impact on Gut Microbiota, Immune Responses, and Brain Health. Nutrients. 2021;13(1).