Published date: Dec 21 2023

Journal Title: West Kazakhstan Medical Journal

Issue title: West Kazakhstan Medical Journal: Volume 65 Issue 4

Pages: 4–43

DOI: 10.18502/wkmj.v65i4.14677

Afsaneh ZareDepartment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Aida IrajiStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Shahrokh ZareStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Omid Koohi-HosseinabadiCentral Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran

Fateme BagheriStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Romina Tanidehrominatanideh@yahoo.comStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Nader TanidehStem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran

Knee osteoarthritis (OA) is a chronic and prevalent musculoskeletal condition that is the underlying cause of disability in most patients worldwide. Even though the pathophysiology of KOA has not yet been fully understood and includes a wide range of risk factors, current therapeutic options are temporarily palliative rather than curative. In recent years, new strategies have focused on the curative agents. As part of this review, we highlight the latest treatment approaches for KOA.

Keywords: osteoarthritis, mesenchymal stem cell, exosome, regeneration medicine, scaffold, mmunotherapy, machine learning

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