Published date: Dec 31 2021

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 16 (2021), Issue No. 4

Pages: 558–566

DOI: 10.18502/sjms.v16i4.9953

Malak Abdulrahman Seid AhmedFaculty of Medical Laboratory sciences, Al-Neelain University, Khartoum, Sudan

Nazik OmerDepartment of oral and maxillofacial surgery, division of oral Pathology, Faculty of Dentistry, University of Khartoum, Sudan

Ahmed M. SulimanDepartment of oral and maxillofacial surgery, division of oral Pathology, Faculty of Dentistry, University of Khartoum, Sudan

Mona EllaithiFaculty of Medical Laboratory sciences, Al-Neelain University, Khartoum, Sudan

Background: Cyclin D1 expression regulates normal cell cycle. Its deregulation or overexpression may cause disruption in the normal cell cycle control and lead to cancer progression. In this study, we aimed to study the expression of cyclin D1 in oral squamous cell carcinoma (OSCC) and find its association with the different grades of oral tumors, if any. 

Methods: This cross-sectional study included 40 formalin-fixed paraffin-embedded tissue blocks specimens of OSCC with variable grades. The expression of cyclin D1 was evaluated through immunohistochemical (IHC) staining.

Results: There were 9 female and 31 male samples, with a male-to-female ratio of 3.4:1. The age ranged between 25 and 90 years with an average age of 65.5 years. Twenty-five (62.5%) samples were diagnosed as well-differentiated squamous cell carcinoma (WDSCC) and fifteen (37.5%) as poorly differentiated squamous cell carcinoma (PDSCC). No cases of moderately differentiated squamous carcinoma were included in the study. The expression of cyclin D1 was detected in the cases of WDSCC and a lesser expression was seen in the PDSCC with a P-value of 0.0003, OR 1581 and 95% CI (29.8239 to 83810.7113).

Conclusion: Cyclin D1 is expressed in  OSCC and stronger expression was detected in WDSCC.

Keywords: Cyclin D1, oral squamous cell carcinoma (OSCC), Toombak, Sudanese oral cancer, immunohistochemistry

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