Published date: Sep 30 2020

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 15 (2020), Issue No. 3

Pages: 249–258

DOI: 10.18502/sjms.v15i3.7746

Abuagla M. DafallaDepartment of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan

Leena A. DafallaNational Cancer Institute, University of Gezira, Sudan

ShamsEldein M. AhmedDepartment of Clinical Chemistry, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan

Yousif A. MohammedNational Cancer Institute, University of Gezira, Sudan

Adam D. AbakarDepartment of Medical Parasitology, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan

Wed elbahar H. AballahDepartment of hematology and immunohematology Faculty of Medical Laboratory Sciences, Managil University of Science and Technology Sudan

Elhadi A. AhmedDepartment of Medical Microbiology, Faculty of Medical Laboratory Sciences, University of Gezira, Sudan

GadAllah ModaweDepartment of Biochemistry, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Omdurman, Sudan

Background: Cardiac diseases are one of the major causes of death worldwide with increasing incidence rate per year, particularly in developing countries such as Sudan owing to urbanization and changing lifestyle. Myocardial infarction is a consequence of the imbalance between the heart blood supply and the required heart cell; this disorder leads to necrosis of myocardium and may cause death. It could be diagnosed by at least two of the following criteria: chest pain, electrocardiography (ECG) elevation, and levels on cardiac biomarkers. This study aimed to evaluate the efficiency of N-terminal pro-B-type natriuretic peptide (NTproBNP) for the diagnosis of acute myocardial infarction (AMI).

 Methods: This analytical case–control hospital-based study was conducted on a total of 70 individuals, of which 40 participants were suspected of or diagnosed with AMI, while 30 healthy subjects  were included as a control group. Three ml of venous blood were collected in lithium heparin containers. Troponin I (TnI) as a cardiac biomarker was measured by TOSOH AIA-360, while the NTproBNP level was detected using I-Chroma II. Personal and clinical data were collected directly from each participant using a predesigned questionnaire.

Results: A significant increase in the TnI level (mean: 13.13 ± 18.9 ng/ml) and NTproBNP (mean: 5756.5 ± 8378.2 pg/mL) in AMI patients were detected when compared with control mean (0.02 ± 0.00 ng/ml and 57.8 ± 42.32 pg/mL, respectively).

Conclusions: NTproBNP gave a high sensitivity (87.5%), specificity (100%), positive predictive value (100%), and negative predictive value (85.7%) in the diagnosis of AMI when compared with another cardiac biomarker such as TnI.

Keywords: acute myocardial infarction, NTproBNP, troponin I, Medani Heart Center, Sudan

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