Sudan Journal of Medical Sciences

ISSN: 1858-5051

High-impact research on the latest developments in medicine and healthcare across MENA and Africa

Ceftriaxone Drug Utilization Evaluation (DUE) at Prince Abdulaziz Bin Moussae’ed Hospital, Arar, Kingdom of Saudi Arabia

Published date: Dec 26 2019

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 14 (2019), Issue No. 4

Pages: 266–275

DOI: 10.18502/sjms.v14i4.5905

Authors:

Muhammad Jan Shamsur Rehmanrmuhammadjansmc@gmail.comDepartment of Pharmacology, College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia

Majed AlrowailiDepartment of Orthopedic, Prince Abdulaziz Bin Mossae’ed Hospital & College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia

Abdul Wajed Abdul RaufInternal Medicine, Prince Abdulaziz Bin Moussae’ed Hospital, Arar, KSA

Elhassan Hussein EltomDepartment of Pharmacology, College of Medicine, Northern Border University, Arar, Kingdom of Saudi Arabia

Abstract:

Introduction: Bacterial resistance to the most commonly used drug ceftriaxone and its adverse effects have increased due to its injudicial use. Drug Utilization Evaluation (DUE) is an ongoing, systematic process designed to promote the appropriate and effective use of drugs. The purpose was to detect potential problems and search out solution.

Methods: Data were collected in structured preform specific for DUE and were represented as numbers and percentages. For comparing numerical data, Mann–Whitney U-test was used as the data were non-parametric in distribution for ages and BMI, while Fisher exact test was used for categorical data comparison. Multivariate multi-logistic regression models to study the overlapped effect of the variables in development of Ceftriaxone induced liver functions derangement. Data were processed and analyzed using SPSS16 for statistical analysis.  Significance was considered as P < 0.05.

Results: Our study showed that ceftriaxone use was more. High dose was used and for more than 10 days were the result of adverse effects and liver insult.

Conclusion There is need for awareness among the general practitioners and clinicians to ensure rational use of antibiotics. This will minimize bacterial resistance to drug, adverse effects and save national economy.

Keywords: Ceftriaxone, Drug utilization evaluation

References:

[1] Qingping, S., Feng, D., Ran, S., et al. (2013). Drug use evaluation of cefepime in the first affiliated hospital of Bengbu medical college: A retrospective and prospective analysis. BMC Infectious Diseases, vol. 13, no. 1, p. 160.

[2] Lee, H., Jung, D., Yeom, J. S., et al. (2009). Evaluation of ceftriaxone utilization at multi-center study. Korean Journal of Internal Medicine, vol. 24, no. 4, pp. 374–380.DOI: 2009;10, 3904.Kjim

[3] Laxminarayan, R., Bhutta, Z., Duse, A., et al. (2005). Drug resistance, in Disease Control Priorities in Developing Countries, pp. 1031–1051.

[4] William, F. and Janis, E. (1996). The cephalosporins. Mayo Clinic Proceedings, vol. 74, pp. 187–195.

[5] Chong, Y. and Lee, K. (2000). Present situation of antimicrobial resistance in Korea. Journal of Infection and Chemotherapy, vol. 6, pp. 189–195.

[6] Holmberg, S. D., Solomon, S. L., and Blake, P. A. (1987). Health and economic impacts of antimicrobial resistance. Reviews of Infectious Diseases, vol. 9, pp. 1065–1078.

[7] American Society of Health-System Pharmacists. (1996). ASHP guidelines on medication-use evaluation. American Journal of Health-System Pharmacy, vol. 53, pp. 1953–1955.

[8] Holloway, K. and Green, T. (2003). Drug and Therapeutics Committees - A Practical Guide. Geneva, Switzerland: World Health Organization, Department of Essential Drugs and Medicines Policy.

[9] Panavila, L., Ninan, N., and Pratima, K. C. (2016). Drug use evaluation of third generation cephalosporin in a tertiary care teaching hospital . International Journal of Therapeutic Applications, vol. 32, pp. 81–85.

[10] Kaliamoorthy, K., Sankaralingam, R., Punniyakotti, S., et al. (2012). Drug utilization evaluation of third generation cephalosporins using core drug use indicators. Pakistan Journal of Pharmaceutical Sciences, vol. 25, no. 2, pp. 339–342.

[11] Amos, M. Y., Yitzhack, S., Yechiel, S., et al. (2000). Cefuroxime utilization evaluation: Impact of physician Education on prescribing patterns. IMAJ, vol. 2, pp. 187–191.

[12] Abou-Shaaban, M., Ali, A. A., Rao, P. G., et al. (2016). Drug utilization review of cephalosporins in a secondary care hospital in United Arab Emirates. International Journal of Clinical Pharmacy, vol. 38, no. 6, pp. 1367–1371.

[13] Naveen, V., Abubakar, S., and Chandana, G. (2018). Drug utilization pattern of cephalosporin. International Journal of Current Pharmaceutical Research, vol. 10, no. 3, pp. 33–36.

[14] Hafte, K., Tefera, K., Azeb, W., et al. (2018). Assessment of ceftriaxone use in Eastern Ethiopian Referral Hospital: A retrospective study. Journal of Infectious Diseases and Medical Microbiology, vol. 2, no. 3, pp. 26–29.

[15] Phelps, C. E. (1989). Bug/drug resistance: Sometimes less is more. Medical Care, vol. 27, pp. 194–203.

Download
HTML
Cite
Share
statistics

987 Abstract Views

337 PDF Downloads