Published date: Dec 29 2023

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 18 (2023), Issue No. 4

Pages: 418–427

DOI: 10.18502/sjms.v18i4.14722

Yousef Rasmirasmiy@umsu.ac.irCellular and Molecular Research Center, Urmia University of Medical Sciences, Urmia, Iran

Mohammad-Hassan Khadem-AnsariDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Neda ValizadehDepartment of Endocrinology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Fariba ValipourDepartment of Biology, Faculty of Science, Islamic Azad University, Tehran, Iran

Mohadeseh NematiDepartment of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran

Fariba KhosravifarDepartment of Science, Payame Noor University, Tehran, Iran

Mahdieh NematiDepartment of Medical Nanotechnology, Faculty of Advanced Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

Background: Metabolic risk factors play a critical role in metabolic syndrome (MetS), and endothelial dysfunction is important in its development. On the other hand, Helicobacter pylori (H. pylori) infection has an essential role in MetS. The goal of present study was to evaluate the effect of H. pylori infection on endothelial dysfunction in MetS patients.

Methods: Based on the International Diabetes Federation (IDF) criteria, 80 MetS patients (59 females and 21 males, mean age: 48.94 ± 10.00 years) were selected. Plasma samples were assayed for H. pylori IgG using the ELISA method. Endothelial function was also evaluated by measuring plasma concentrations of endothelin-1 (ET-1), E-selectin, and intracellular adhesion molecule-1 (ICAM-1) using ELISA method. Also, NO₂^– and NO₃^– concentrations were measured by Griess method.

Results: Fifty patients (62.5%) had H. pylori infection. Plasma concentrations of ET- 1, NO₂^–, and NO₃^– were significantly higher in MetS patients with positive H. pylori infection than in MetS patients with negative H. pylori infection (ET-1: 2.92 ± 2.33 vs 1.9 ± 1.4 pg/ml; P = 0.037; NO₂^–:19.46 ± 7.11 vs 15.46 ± 4.56 μM; P = 0.003; NO₃^–: 20.8 ± 10.53 vs 16.85 ± 6.03 μM, P = 0.036). However, plasma concentrations of ICAM-1 and E-selectin did not show any significant difference in the two groups.

Conclusion: The results showed a relationship between H. pylori infection and endothelial dysfunction. H. pylori infection can lead to atherosclerosis by causing chronic inflammation and affecting the factors contributing to the MetS.

Keywords: metabolic syndrome, H. pylori, endothelial dysfunction

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