Published date: Sep 27 2023

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 18 (2023), Issue No. 3

Pages: 284–290

DOI: 10.18502/sjms.v18i3.14083

Dalya M. M. AbdelmagedFaculty of Medicine, Al Neelain University, Khartoum, Sudan

Carol A. AvilaUniversidad de Carabobo, Valencia, Venezuela

Abubaker A MohamedSharifFaculty of Medicine, University of Khartoum, Khartoum, Sudan

Isra Bdraldein Salih MohammedIsrabdr1995@gmail.comFaculty of Medicine, University of Khartoum, Khartoum, Sudan

A 95-year-old man came with violaceous nodular skin lesions of the left shin. The lesions were not painful or pruritic but progressed rapidly over the 3 months. Fever, night sweats, weight loss, and other systemic symptoms were absent. Shave biopsy of the lesion revealed the cells negative for CD20 but positive for BCL2, BCL6, FOX-P1, and CD10. PET/CT showed high uptake in the left leg and a sizeable hypermetabolic lymph node in the left pelvis. The patient was started on rituximab treatment as a single agent. This report highlights some of the diagnostic and treatment difficulties in CD20 negative lymphomas and the importance of a multidisciplinary approach in those cases.

Keywords: diffuse large B-cell lymphoma, leg type (DLBCL-LT), primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT), positron emission tomography/computed tomography (PET/CT), cluster of differentiation (CD), B-cell lymphoma 2 (BCL2), B-cell lymphoma 6 (BCL6), Forkhead box P1 (FOX-P1), cmyelocytomatosis oncogene product (C-MYC), multiple myeloma oncogene 1 (MUM1), Epstein-Barr virus (EBV)-encoded RNA 1 (EBER-1)

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