Published date: Dec 28 2017

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 12 (2017), Issue No. 4

Pages: 215-230

DOI: 10.18502/sjms.v12i4.1353

Alsarah Mutwakil Abbas Diab

Eman MutwakilAhmedAlmostafa Suliman

AyatAbdallah Hassan Abdallah

Mohamed AbdelhadiElzubair Dyab

Tanzeel Omer Elamin Awadalla

Naila Mubarak Kirkisawi

Nazik Elmalaika Obaid Seid Ahmed Husain

Background:Beta2 (β2) agonists as relievers and corticosteroids as controllers are the mainstay drugs for asthma treatment. Benign Joint Hypermobility Syndrome (BJHS) is a connective tissue disorder with musculoskeletal symptoms.

We had examined the possible association between the use of β2 agonists and corticosteroids and acquiring BJHS in asthmatic patients.

Methods:This was a case-control, hospital-based study including a group of asthmatics who had BJHS (cases), compared with a matched group of asthmatics without BJHS (controls) for the β2 agonists and corticosteroids past and current pattern of use. Information was collected by face-to-face interview and clinical examination and from subjects’ medical records using pre-structured questionnaire. BJHS diagnosis was based on the revised Brighton criteria. Asthma severity was reflected by a score, which was calculated from the asthma questionnaire. Comparison of exposure was done by Calculation of Odds Ratio.

Results:

Development of BJHS was found to be significantly associated with chronicity of asthma of average duration of 13.2 years, and hence to prolonged use of β2 agonists and/or corticosteroids (OR 1.019; 95% CI 0.999 - 1.039, P=0.006)

Exposure to β2 agonist and corticosteroid (87 and 79 cases and controls respectively P=0.05)high asthma score (42.9 ± 9.8 and 40.4 ± 8.3 among cases and controls respectively, P=0.011) were significantly associated with the development of BJHS.

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