Published date: Oct 04 2024

Journal Title: KnE Life Sciences

Issue title: 4th International Conference in Social Science (4th ICONISS): Healthcare

Pages: 105–110

DOI: 10.18502/kls.v8i2.17363

Gusti Ayu Sinta Deasy Andanigusti.sinta@gmail.comDepartment of Physiology, Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi

Gusti Ngurah Putu Eka PutraCNRS UMR9187, INSERM U1196, Institut Curie, PSL Research University, Orsay

Although physical activity is important for the athlete’s health and performance, it may also lead to Deoxyribonucleic Acid (DNA) damage, which may have long-term health consequences and affect performance. This article summarizes different types of DNA damage that may occur in athletes, including their potential risk causes, such as mechanical stress, heat stress, and oxidative stress. Furthermore, several mechanisms by which physical activity might lead to DNA damage and affect health and performance are also discussed. Various strategies such as diet and nutrition, antioxidant supplements, cooling strategies, and recovery modalities are also presented to mitigate, prevent, and minimize the potential DNA damage upon physical activities. This article also highlights case studies of athletes who have experienced DNA damage and the effects on their performance and health. In summary, this article offers valuable perspectives on the intricate relationship between physical activity and DNA damage as well as the importance of addressing this issue in the context of athletic performance and health.

Keywords: athlete, DNA damage, exercise, RONS

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