Published date: Jun 07 2022

Journal Title: KnE Life Sciences

Issue title: The First Asian PGPR Indonesian Chapter International e-Conference 2021

Pages: 613–620

DOI: 10.18502/kls.v7i3.11166

Winny Andaliawinnyandalia@univ-tridinanti.ac.idTridinanti of University, Palembang, Indonesia

Cindi RamayantiChemical Engineering Department, State Polytechnic of Sriwijaya, Indonesia

Fariliyn DanisyaManagement Entrepreneur and Innovation Department, Indonesia

The COVID-19 pandemic continues to be a global issue that draws worldwide attention. Countries are racing to develop vaccines and drugs to combat the COVID-19 virus. Immunomodulators are used in some of the prevention efforts. Any drug or substance that affects the immune system is classified as an immunomodulator. Bovine colostrum is an example of an immunomodulator. Colostrum is the mammary gland’s first secretion after birth, and it differs from mature milk in that it contains more proteins, immunoglobulin-A, vitamins, minerals, bactericides (lactoferrin, lysozyme, and lactoperoxidase), and growth factors. This review examines immunomodulators across various perspectives and characteristics, as an alternative for increasing the body’s resistance, and possible mechanisms are discussed. This review thereby facilitates the choice of suitable immune enhancement for the prevention and treatment of COVID-19.

Keywords: Bovine colostrum, Immonumodulator, Covid-19

[1] World Health Organization (WHO). Situation report – 10. WHO; 3 June 2020. Available from: https://cdn.who.int/media/docs/default-source/searo/indonesia/covid19/ who-situation-report-10.pdf?sfvrsn=2bf49429_2

[2] Lu R, Zhao X, Li J et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: Implications for virus origins and receptor binding. Lancet. 2020;395;565-74.

[3] Khotimah K, Fahrizal. Microbilogical quality of FH dairy cow colostrum at different milking times in peoples farms. Journal of Animal Science. 2013;13(2):13–17.

[4] World Health Organization, Food and Agriculture Organization. Health and nutritional properties of probiotics in food including powder milk with live lactic acid bacteria. Joint FAO/WHO Expert Consultation. Cordoba, Argentina; 2001.

[5] Hill C, Guarner F, Reid G et al. Expert consensus document. The International Scientific Association for Probiotics consensus statement on the scope and appropriate use of the term probiotics. Nature Reviews Gastroenterology & Hepatology. 2014;11:506-514.

[6] Grzeakowiak A, Isolauri E, Salminen S, Gueimonde M. Manufacturing process influences properties of probiotic bacteria. British Journal of Nutrition. 2011;105:887- 894.

[7] Hofmeyr SA. Design principles for the immune system and other distributed autonomous systems. Cohen I, Segel L, editors. New York: Oxford University Press, Inc; 2001.

[8] Su GL, Ko CW, Bercik P, Morgan RL et al. Spotlight: Probiotics guidelines. Gastroenterology. 2020;159(2):707. https://doi.org/10.1053/j.gastro.2020.07.025

[9] Murphy K, Travers P, Walport M, Janeway C. Janeway’s immunobiology. 9th ed. New York: Garland Science; 2016.

[10] Lebeer S, Vanderleyden J, De Keersmaecker SC. Host interactions of probiotic bacterial surface molecules: Comparison with commensals and pathogens. Nature Reviews Microbiology. 2010;8(3):171–184. https://doi.org/10.1038/2297

[11] Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. Nature Reviews Immunology. 2012;12(10):728– 734. https://doi.org/10.1038/3312

[12] Bron PA, van Baarlen P, Kleerebezem M. Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nature Reviews Microbiology. 2012;10(1):66–78. https://doi.org/10.1038/2690

[13] World Health Organization. Transmission of SARS-CoV-2: implications for infection prevention precautions: scientific brief, 09 July 2020. World Health Organization. 2020. https://apps.who.int/iris/handle/10665/333114. License: CC BY-NC-SA 3.0 IGO

[14] Ahmadi M, Velciov AB, Scurtu M, Ahmadi T, Olariu L. Benefits of bovine colostrum in nutraceutical products. Journal of Agroalimentary Processes and Technologies. 2011;17(1):42-45.

[15] Poonia A, Dabur RS. Physico-chemical and sensory properties of khees obtained from buffalo and cow colostrum. Journal of Dairying, Foods & Home Sciences. 2012;31(4):256-258.

[16] Saalfeld MH, Pereira DIB, Silveira KRK et al. Colostro: A redescoberta de um alimento saudável, nutritivo e com potencial probiótico. Agroecologia e Desenvolvimento Rural Sustentável. 2012;5(2):18-24.

[17] Mouton E, Aryana KJ. Influence of colostrum on the characteristics of ice cream. Food and Nutrition Sciences. 2015;6(5):480-484. http://dx.doi.org/10.4236/fns.2015.65049

[18] Ayar A, Siçrama H, Çetin I. The effect of bovine colostrum on the lactic flora of yogurt and kefir. JSM Biotechnology & Biomedical Engineering. 2016;4(3):1063:1-6.

[19] Das AD, Seth R. Studies on quality attributes of skimmed colostrum powder. International Journal of Chemical Studies. 2017;3(5):17-20.

[20] Abdel-Ghany AS, Zaki DA. Production of novel functional yoghurt fortified with bovine colostrum and date syrup for children. Alexandria Science Exchange Journal. 2018;39(10):651-662. https://doi.org/10.21608/asejaiqjsae.2018.20475

[21] Nazir T, Pal MA, Manzoor A. Effect of admixing varying levels of whole milk to the colostrum on the sensory quality of fermented colostrum product. International Journal of Advanced Research in Science, Engineering and Technology. 2018;7(4):156-161.

[22] Setyawardani T, Sumarmono J, Arief II, Rahardjo AHD, Widayaka K, Santosa SS. Improving composition and microbiological characteristics of milk kefir using colostrum. Food Science and Technology. Campinas. 2020;40(2):699-707. https://doi.org/10.1590/fst.31719

[23] Silva EG, Anaya K, Bezerra MDF, Macêdo CS, Urbano SA, Borba LH, Rangel AH. Physicochemical and sensory evaluation of Greek style yoghurt with bovine colostrum. Food Science and Technology. Campinas. 2021:42:1-7. https://doi.org/10.1590/fst.22121