Published date: Jun 07 2022

Journal Title: KnE Life Sciences

Issue title: The First Asian PGPR Indonesian Chapter International e-Conference 2021

Pages: 79–85

DOI: 10.18502/kls.v7i3.11109

N W BogorianiDepatment of Chemistry, Faculty of Mathematic and Natural Science, University of Udayana. Jl. Kampus Jimbaran Badung, Bali, Indonesia

V A D AtmajaDepatment of Chemistry, Faculty of Mathematic and Natural Science, University of Udayana. Jl. Kampus Jimbaran Badung, Bali, Indonesia

O RatnayaniDepatment of Chemistry, Faculty of Mathematic and Natural Science, University of Udayana. Jl. Kampus Jimbaran Badung, Bali, Indonesia

I N WirajanaDepatment of Chemistry, Faculty of Mathematic and Natural Science, University of Udayana. Jl. Kampus Jimbaran Badung, Bali, Indonesia

The Balinese plant andong (Cordyline terminalis Kunth) has anti-inflammatory properties. The focus of this research was to determine whether andong leaf extract has anti-inflammatory properties and is effective against carrageenan-induced edema in rat soles. In this study, carrageenan was used to induce inflammation in the soles of Wistar rats. 25 rats were divided into five treatment groups. Group I was given aquadest as the control; group II was given diclofenac sodium at a dose of 4.5 mg/kgbw as a drug control; and groups III, IV and V were given ethanol extract of andong leaves at doses of 150 mg/kgbw, 300 mg/kgbw, and 600 mg/kgbw orally as test groups. For six hours, the inflammation volume was measured using a plethymometer. One-way ANOVA was used to test differences between the treatment groups. The results showed that the ethanol extract of andong leaves had the highest anti-inflammatory activity in the six-hour period when given at doses of 150 mg/kgbw (36.35% 0.02), 300 mg/kgbw (26.30% 0.20), and 600 mg/kgbw (20.67% 0.16) with a significant difference (p < 0.05) compared to the negative control (86.84% 0.092), but this was not significantly different from the positive control (22.21% 0.01). Based on these findings, it can be concluded that a dose of 600 mg/kgbw is the most effective in reducing inflammation.

Keywords: Anti-inflammatory, Red andong leaf, Carrageenan, Wistar rat, Edema

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