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This study aimed to investigate the dependence of the biocidal activity of polyguanidine (co)polymers on their structure during the formation of biofilms by active PE-degrading cultures of model microorganisms. The Bc-2 copolymer of methacryloyl guanidine hydrochloride (MGHC) and diallyldimethylammonium chloride (DADMAC), which suppressed both the formation of biofilms and the growth of planktonic cultures, exhibited the highest activity. When PE was exposed in tropical soil, the composition of the microbial community on the PE surface differed significantly from that of the community in the surrounding soil. In particular, the proportion of Actinobacteria increased from 7% to 29%, while the proportion of Bacteroidetes decreased from 38% to 8%.
Keywords: biofilms, polyhexamethylene guanidine salts, dynamics of biofilm formation, antibiofilm effect, composite materials
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[2] Brzezinska SM, Walczak M, Jankiewizs U et al. Antimicrobial activity of polyhexamethylene guanidine derivatives introduced into polycaprolactone. Journal of Polymers and the Environment. 2018;26:589–595.

[3] Ghamrawi S, Bouchara J-P, Tarasyuk O et al. Promising silicones modified with cationic biocides for the development of antimicrobial medical devices. Materials Science and Engineering. 2017; 75:969–979.

[4] Gerasin VA, Mendeleev DI, Kurenkov VV et al. Guanidine-containing organomineral complexes as biocide additives to polymeric composites. Russian Journal of Applied Chemistry. 2018;91:1297–1304.

[5] Sivov NA. Biocide guanidine containing polymers: Synthesis, structure and properties. Moscow, Russia, CRC Press; 2006.

[6] Mart’yanov SV, Zhurina MV, El’ Registan GI et al. Activation and prevention of formation of bacterial biofilms by azithromycin. Microbiology (Moscow). 2014;83(6):723–731.

[7] Gannesen AV, Zhurina MV, Veselova MA, et al. Regulation of biofilm formation by Pseudomonas chlororaphis in an in vitro system. Microbiology. 2015;84:319–327.

[8] Plakunov VK, Mart’yanov SV, Teteneva NA et al. A universal method for quantitative characterization of growth and metabolic activity of microbial biofilms in static models. Microbiology. 2016;85:509–513.

[9] Zhurina MV, Kallistova AYu, Panyushkina AE et al. Specific features of formation of multispecies microbial biofilms on polyethylene surface. Microbiology. 2020;89(40):396–404.

[10] Divyalakshmi S, Subhashini A. Screening and isolation of polyethylene degrading bacteria from various soil environments. IOSR Journal of Environmental Science, Toxicology and Food Technology. 2016;10:1–7."
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Use of Polyguanidine-Derivatives-Based Biocides for Microbial Growth Inhibition and for the Development of a Novel Polyethylene-Based Composite Material Resistant to the Formation of Multispecies Microbial Biofilms

Published date: Jan 13 2022

Journal Title: KnE Life Sciences

Issue title: 8th Scientific and Practical Conference "Biotechnology: Science and Practice"

Pages: 456–468

DOI: 10.18502/kls.v7i1.10155

Authors:

Marina Zhurinamzhurik@mail.ruWinogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071 Russia

Andrei GannesenWinogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071 Russia

Sergey MartyanovWinogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071 Russia

Anna KallistovaWinogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071 Russia

Victor GerasinTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991 Russia

Nikolai SivovTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991 Russia

Vsevolod TikhomirovTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991 Russia

Ahkar Kaung MyintTopchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, 119991 Russia

Vladimir PlakunovWinogradsky Institute of Microbiology, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 119071 Russia

Abstract:

This study aimed to investigate the dependence of the biocidal activity of polyguanidine (co)polymers on their structure during the formation of biofilms by active PE-degrading cultures of model microorganisms. The Bc-2 copolymer of methacryloyl guanidine hydrochloride (MGHC) and diallyldimethylammonium chloride (DADMAC), which suppressed both the formation of biofilms and the growth of planktonic cultures, exhibited the highest activity. When PE was exposed in tropical soil, the composition of the microbial community on the PE surface differed significantly from that of the community in the surrounding soil. In particular, the proportion of Actinobacteria increased from 7% to 29%, while the proportion of Bacteroidetes decreased from 38% to 8%.

Keywords: biofilms, polyhexamethylene guanidine salts, dynamics of biofilm formation, antibiofilm effect, composite materials

References:

[1] Ramasamy M, Lee J. (2016). Recent nanotechnology approaches for prevention and treatment of biofilm-associated infections on medical devices. BioMed Research International. 2016;2016:1851242-1851242. DOI: 10.1155/2016/1851242

[2] Brzezinska SM, Walczak M, Jankiewizs U et al. Antimicrobial activity of polyhexamethylene guanidine derivatives introduced into polycaprolactone. Journal of Polymers and the Environment. 2018;26:589–595.

[3] Ghamrawi S, Bouchara J-P, Tarasyuk O et al. Promising silicones modified with cationic biocides for the development of antimicrobial medical devices. Materials Science and Engineering. 2017; 75:969–979.

[4] Gerasin VA, Mendeleev DI, Kurenkov VV et al. Guanidine-containing organomineral complexes as biocide additives to polymeric composites. Russian Journal of Applied Chemistry. 2018;91:1297–1304.

[5] Sivov NA. Biocide guanidine containing polymers: Synthesis, structure and properties. Moscow, Russia, CRC Press; 2006.

[6] Mart’yanov SV, Zhurina MV, El’ Registan GI et al. Activation and prevention of formation of bacterial biofilms by azithromycin. Microbiology (Moscow). 2014;83(6):723–731.

[7] Gannesen AV, Zhurina MV, Veselova MA, et al. Regulation of biofilm formation by Pseudomonas chlororaphis in an in vitro system. Microbiology. 2015;84:319–327.

[8] Plakunov VK, Mart’yanov SV, Teteneva NA et al. A universal method for quantitative characterization of growth and metabolic activity of microbial biofilms in static models. Microbiology. 2016;85:509–513.

[9] Zhurina MV, Kallistova AYu, Panyushkina AE et al. Specific features of formation of multispecies microbial biofilms on polyethylene surface. Microbiology. 2020;89(40):396–404.

[10] Divyalakshmi S, Subhashini A. Screening and isolation of polyethylene degrading bacteria from various soil environments. IOSR Journal of Environmental Science, Toxicology and Food Technology. 2016;10:1–7.

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