KnE Energy

Published date: Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages: 162–167

DOI: 10.18502/ken.v3i2.1808

M I Kovalevkovalev03z@mail.ru

A M Kovaleva

A I Ischenko

I P Shilov

Yu V Alekseev

A V Ivanov

V D Rumyantseva

V I Voznesensky

V M Pominalnaya

A O Garina

The article summarizes the experience of using luminescent diagnostics with the use of ytterbium porphyrin complexes in gynecology and oncology. A pharmaceutical composition based on the Yb complex of 2,4-dimethoxyhematoporphyrin IX was used as the luminescent markers within the infrared range. The determination of luminescence characteristics (luminescence intensity) was carried out using a laserfiber fluorimeter in the range of 900-1100 nm. A new method for diagnosis of cervical disease has been proposed. The method of luminescent diagnostics allows to conduct a survey of a large number of patients in a short time. The method of luminescent diagnostics using the ytterbium complexes of porphyrins is not invasive. The method can be used as a screening. Differences between normal and pathologically altered cervical tissue have been identified and differences between pathological changes in the cervix HSIL (CIN II, CIN III) and cervical cancer are reliable.

Keywords: Cervical cancer, squamous cell carcinoma, diagnosis of cervical cancer, squamous intraepithelial lesions of high grade – HSIL, luminescent diagnostics, luminescing in the near infrared (NIR) spectral region, porphyrins, ytterbium complexes of porphyrins.

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