KnE Energy

ISSN: 2413-5453

The latest conference proceedings on energy science, applications and resources

In Vitro Cytotoxicity of CdSe/ZnS Quantum Dots and Their Interaction with Biological Systems

Published date: Apr 17 2018

Journal Title: KnE Energy

Issue title: The 2nd International Symposium "Physics, Engineering and Technologies for Biomedicine"

Pages: 58–63

DOI: 10.18502/ken.v3i2.1792

Authors:
Abstract:

Semiconductor nanocrystals (quantum dots, QDs) have a wide range of potential application in multiplexed tissue and cell imaging, and for in vivo molecular diagnostics and therapy. Therefore studying of the toxicity of QDs and their influence on various cellular processes in vitro is necessary to understand their interaction with living systems.; The paper presents the results of studies on the evaluation of CdSe/ZnS QD cytotoxicity, as well as the results of studying their interaction with freshly prepared human monocytes in vitro.

Keywords: Quantum dots, semiconductor nanocrystals, cytotoxicity, in vitro models, monocytes.

References:

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[2] Montenegro J.M., Grazu V., Sukhanova A., Agarwal S., de la Fuente J.M., Nabiev I., Greiner A., Parak W.J., (2013) Controlled antibody/(bio-) conjugation of inorganic nanoparticles for targeted delivery, Adv. Drug Deliv. Rev. Elsevier B.V., 65, 677–688. DOI: 10.1016/j.addr.2012.12.003.


[3] Bilan R., Fleury F., Nabiev I., Sukhanova A., (2015) Quantum dot surface chemistry and functionalization for cell targeting and imaging, Bioconjug. Chem., 26, 609–624. DOI: 10.1021/acs.bioconjchem.5b00069.


[4] Smith A.M., Ruan G., Rhyner M.N., Nie S., (2006) Engineering luminescent quantum dots for in vivo molecular and cellular imaging. Ann. Biomed. Eng., 34, 3–14. DOI: 10.1007/s10439-005-9000-9.


[5] Sukhanova A., Even-Desrumeaux K., Kisserli A., Tabary T., Reveil B., Millot J.M., Chames P., Baty D., Artemyev M., Oleinikov V., Pluot M., Cohen J.H., Nabiev I.. (2012) Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes, Nanomedicine Nanotechnology, Biol. Med., 8, 516–525. DOI: 10.1016/j.nano.2011.07.007.


[6] Brazhnik K., Sokolova Z., Baryshnikova M., Bilan R., Efimov A., Nabiev I., Sukhanova A.. (2015) Quantum dot-based lab-on-a-bead system for multiplexed detection of free and total prostate-specific antigens in clinical human serum samples, Nanomedicine Nanotechnology, Biol. Med. Elsevier Inc., 11, 1065–1075. DOI: 10.1016/j.nano.2015.03.003.


[7] Derfus A.M., Chan W.C.W., Bhatia S.N., (2004) Probing the Cytotoxicity Of Semiconductor Quantum Dots, Nano Lett., 4, 11–18. DOI: 10.1021/nl0347334.


[8] Hoshino A., Hanada S., Yamamoto K., (2011) Toxicity of nanocrystal quantum dots: the relevance of surface modifications, Arch. Toxicol., 85, 707–720. DOI: 10.1007/s00204-011-0695-0.

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