Published date: Jul 29 2021

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: July–September 2021, Volume 16, Issue 3

Pages: 432–461

DOI: 10.18502/jovr.v16i3.9439

Cameron PoleRetina Division, USC Roski Eye Institute, Keck School of Medicine, University of South California, Los Angeles, CA, USA

Hossein Ameriameri@med.usc.eduRetina Division, USC Roski Eye Institute, Keck School of Medicine, University of South California, Los Angeles, CA, USA

Fundus autofluorescence (FAF) has allowed in vivo mapping of retinal metabolic derangements and structural changes not possible with conventional color imaging. Incident light is absorbed by molecules in the fundus, which are excited and in turn emit photons of specific wavelengths that are captured and processed by a sensor to create a metabolic map of the fundus. Studies on the growing number of FAF platforms has shown each may be suited to certain clinical scenarios. Scanning laser ophthalmoscopes, fundus cameras, and modifications of these each have benefits and drawbacks that must be considered before and after imaging to properly interpret the images. Emerging clinical evidence has demonstrated the usefulness of FAF in diagnosis and management of an increasing number of chorioretinal conditions, such as agerelated macular degeneration, central serous chorioretinopathy, retinal drug toxicities, and inherited retinal degenerations such as retinitis pigmentosa and Stargardt disease. This article reviews commercial imaging platforms, imaging techniques, and clinical applications of FAF.

Keywords: Fundus Autofluorescence, Fundus Camera, Near-infrared Autofluorescence, Retinitis Pigmentosa, Scanning Laser Ophthalmoscope, Short-wave Autofluorescence

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