Published date: Apr 29 2021

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: April–June 2021, Volume 16, Issue 2

Pages: 287–290

DOI: 10.18502/jovr.v16i2.9092

Bradley BeatsonWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD

J. Fernando Arevaloarevalojf@jhmi.eduWilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD

The off-label, therapeutic use of intravitreal bevacizumab (IVB) in vascular retinal diseases such as diabetic macular edema and proliferative diabetic retinopathy (PDR) has increased significantly due to its ability to reduce retinal neovascularization and slow progression of disease. Here, we will review the literature and investigative developments on the use of IVB as a preoperative adjuvant to vitrectomy in severe PDR, specifically focusing on its ability to reduce intra- and postoperative complications and its risk for progression or development of traction retinal detachment. In particular, this review will highlight the natural progression of evidence from case series and observations to prospective, randomized clinical trials.

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