Published date: Feb 03 2020

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: January–March 2020, Volume 15, Issue 1

Pages: 45–52

DOI: 10.18502/jovr.v15i1.5942

Ali YousefianEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Saeed Shokoohi-RadEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Reza AbbaszadeganMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Dorsa Morshedi RadImmunology Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Selma ZargariMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Saman MilanizadehMedical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Negar MorovatdarClinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Ramin Daneshvardaneshvarr@mums.ac.irEye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Purpose: To evaluate the association of five different polymorphisms from a genomewide- associated study with susceptibility to glaucoma in the northeast Iranian population.

Methods: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetraamplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method.

Results: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 ± 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 ± 5.7 years were selected for evaluation. There was a significant association between rs3816415 (P = 0.005), rs736893 (P < 0.001), rs7494379 (P < 0.001), and rs1258267 (P = 0.02) with PACG susceptibility. This association could not be shown for rs3739821.

Conclusion: It was revealed that studied variants in GLIS3, EPDR1, FERMT2, and CHAT genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate DPM2-FAM102A.

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