Published date: Nov 30 2023

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: Oct–Dec 2023, Volume 18, Issue 4

Pages: 445–451

DOI: 10.18502/jovr.v18i4.14558

Arman Mashayekhimashayekhi.arman@mayo.eduMayo Clinic Florida, Ophthalmology Department, FL, USA

Mohammad YousafMayo Clinic Florida, Ophthalmology Department, FL, USA

Syril DorairajMayo Clinic Florida, Ophthalmology Department, FL, USA

Kevin WuMayo Clinic Florida, Pathology Department, FL, USA

Isabella WagnerMayo Clinic Florida, Ophthalmology Department, FL, USA

James BollingMayo Clinic Florida, Ophthalmology Department, FL, USA

Purpose: To report the development of malignant epiretinal membrane after radiation of ciliary body melanoma.
Case report: A 65-year-old woman was referred for evaluation of a ciliary body tumor in her right eye. On examination, a pigmented ciliary body tumor, displacing the iris anteriorly, was visible superotemporally and ultrasound biomicroscopy revealed a large solid ciliary body tumor. She was diagnosed with ciliary body melanoma and treated with proton beam radiation. Over the following 29 months, the treated tumor regressed but optical coherence tomography (OCT) showed the development of a dense epiretinal membrane. Enucleation was performed and histopathological examination showed viable melanoma cells in the vitreous cavity with sheet-like growth of viable spindle melanoma cells on the epiretinal surface.
Conclusion: The development of a pigmented epiretinal membrane in eyes with uveal melanoma should raise the possibility of a malignant epiretinal membrane.

Keywords: Uveal Melanoma, Proton Beam Radiation, Uveal Melanoma Seeding, Vitreous Seeding, Epiretinal Seeding, Malignant Epiretinal Membrane

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