Published date: Jan 21 2022

Journal Title: Journal of Ophthalmic and Vision Research

Issue title: January–March 2022, Volume 17, Issue 1

Pages: 118–122

DOI: 10.18502/jovr.v17i1.10176

J Gonzalez Barlatayjoaquingonzalezbarlatay@gmail.comDivision of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Argentina

C Pagano BozaDivision of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Argentina

GV Hernandez GaunaDivision of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Argentina

JE PremoliDivision of Orbital and Ophthalmic Plastic Surgery, Hospital Italiano de Buenos Aires, Argentina

The aim of this review was to describe orbital inflammation secondary to aminobisphosphonates by analyzing demographic data, clinical presentation, and treatment of the disease. This is a narrative literature review. The search was performed using databases such as Ovid/MEDLINE and COCHRANE. The searches were limited to papers in the English language. We found 43 cases of orbital inflammation due to aminobisphosphonates. Zoledronate was the drug most associated with orbital side effects. Clinical presentation was evident by unilateral involvement (89%), palpebral edema (88%), conjunctival congestion (81%), chemosis (79%), ocular pain (77%), ocular motility impairment (65%), proptosis (56%), and blurred vision (39%). It can affect both eyes (11%) and is accompanied by anterior uveitis (23%). Orbital inflammation secondary to aminobisphosphonates is a severe side effect. Clinically, it cannot be distinguished from idiopathic inflammation of the orbit. Therefore, it is important to rule out previous drug exposure. Timely treatment is vital to expect a favorable outcome, with systemic corticosteroids being the treatment of choice.

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