Journal of Environmental Treatment Techniques

Published date: Dec 20 2024

Journal Title: Journal of Environmental Treatment Techniques

Issue title: Journal of Environmental Treatment Techniques: Volume 12, Issue 4

Pages: 39 - 66

DOI: 10.18502/jett.v12i4.17971

Amirreza Talaieamirtkh@yahoo.comDepartment of Civil Engineering, Jami Institute of Technology, Isfahan

Seyed Mojtaba MousaviDepartment of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607

This comprehensive review examines the significant health effects of ultraviolet (UV) radiation, highlighting its impact on skin and eye health, immune function, and reproductive health. Prolonged exposure to UV rays is a well-established risk factor for various forms of skin cancer, including melanoma and non-melanoma types, as well as conditions such as cataracts and photokeratitis. The mechanisms through which UV radiation exerts these harmful effects include DNA damage, oxidative stress, and immune suppression, underscoring the need for protective measures. The UV Index is introduced as a vital tool for assessing UV intensity and informing individuals about the risks associated with sun exposure. By implementing effective sun safety strategies, such as using sunscreen, wearing protective clothing, and seeking shade, individuals can significantly mitigate their risk of UV-related health issues. As the understanding of UV radiation’s health effects continues to evolve, public awareness and education remain crucial in promoting long-term skin and eye health, as well as overall well-being. This review emphasizes the importance of proactive measures in protecting against the growing risks associated with increased UV exposure in today’s environment.

Keywords: Ultraviolet Radiation, Skin Cancer, Immune Suppression, UV Index, Sun Protection

[1] Vollmer, M.J.E.t.i.f.s., Physics of the electromagnetic spectrum. 2021: p. 1-32.

[2] Sharma, R. and N. Singh, Introduction to UV-B Radiation, in UV-B Radiation and Crop Growth. 2023, Springer. p. 1-11.

[3] Ke, Y. and X.-J.J.J.o.I.D. Wang, TGFβ signaling in photoaging and UV-induced skin cancer. 2021. 141(4): p. 1104-1110.

[4] Holick, M.F.J.S., Vitamin D and S. Cancer, Sunlight, UV radiation, vitamin D, and skin cancer: how much sunlight do we need? 2020: p. 19-36.

[5] Knuschke, P.J.C.i.S.P., Sun exposure and vitamin D. 2021. 55: p. 296-315.

[6] Borecka, O., et al., A newly developed and validated LC–MS/MS method for measuring 7-dehydrocholesterol (7DHC) concentration in human skin: a tool for vitamin D photobiology research. 2022. 21(11): p. 2001-2009.

[7] Usera, A.R., Studies in organic synthesis: Vitamin D analogs, conjugate addition reactions, and trioxane analogs. 2008: The Johns Hopkins University.

[8] Maestro, M.A., F. Molnar, and C.J.J.o.m.c. Carlberg, Vitamin D and its synthetic analogs. 2019. 62(15): p. 6854- 6875.

[9] Holick, M.F.J.N., The One-Hundred-Year Anniversary of the discovery of the Sunshine Vitamin D3: Historical, personal experience and evidence-based perspectives. 2023. 15(3): p. 593.

[10] Henry, H.L.J.B.p., r.C. endocrinology, and metabolism, Regulation of vitamin D metabolism. 2011. 25(4): p. 531-541.

[11] Andress, D.J.K.i., Vitamin D in chronic kidney disease: a systemic role for selective vitamin D receptor activation. 2006. 69(1): p. 33-43.

[12] Gil, Á., et al., Vitamin D: classic and novel actions. 2018. 72(2): p. 87-95.

[13] Jelle, B.P., T.-N.J.C. Nilsen, and B. Materials, Comparison of accelerated climate ageing methods of polymer building materials by attenuated total reflectance Fourier transform infrared radiation spectroscopy. 2011. 25(4): p. 2122-2132.

[14] Shanbhag, T.V.J.E.C., The Ozone Layer, Ultraviolet B Radiation, Climate Change, and Human Health. 2022: p. 116.

[15] Larin, I.J.I., Atmospheric and O. Physics, On the Influence of global warming on the ozone layer and UVB radiation. 2021. 57: p. 110-115.

[16] Han, A., et al., Prolonged UV-C irradiation is a double-edged sword on the zirconia surface. 2020. 5(10): p. 5126-5133.

[17] Chawla, A., et al., UV light application as a mean for disinfection applied in the dairy industry. 2021. 11(16): p. 7285.

[18] Turner, J., et al., A review on the ability of smartphones to detect ultraviolet (UV) radiation and their potential to be used in UV research and for public education purposes. 2020. 706: p. 135873.

[19] Huang, X. and A.N.J.A.o.b.e. Chalmers, Review of wearable and portable sensors for monitoring personal solar UV exposure. 2021. 49(3): p. 964-978.

[20] Neale, R., et al., The effects of exposure to solar radiation on human health. 2023. 22(5): p. 1011-1047.

[21] WHO. Radiation: The ultraviolet (UV) index. 2022 20 June 2022 [cited 2024 6 Nov 2024]; Available from: https://www.who.int/news-room/questions-and-answers/item/radiation-the-ultraviolet-(uv)-index.

[22] Vitt, R., et al., UV-Index climatology for Europe based on satellite data. 2020. 11(7): p. 727.

[23] Wright, C.Y. and M.J.F.i.P.H. Norval, Health risks associated with excessive exposure to solar ultraviolet radiation among outdoor workers in South Africa: an overview. 2021. 9: p. 678680.

[24] Snyder, A., et al., Solar ultraviolet exposure in individuals who perform outdoor sport activities. 2020. 6: p. 1-12.

[25] Merin, K., M. Shaji, and R.J.I.J.o.D. Kameswaran, A review on sun exposure and skin diseases. 2022. 67(5): p. 625.

[26] Nurla, L.-A., et al., Recent-Onset Melanoma and the Implications of the Excessive Use of Tanning Devices—Case Report and Review of the Literature. 2024. 60(1): p. 187.

[27] Knuschke, P.J.K.s.O.D., UV exposure. 2020: p. 1145-1178.

[28] Vechtomova, Y.L., et al., UV radiation in DNA damage and repair involving DNA-photolyases and cryptochromes. 2021. 9(11): p. 1564.

[29] Khan, N.H., et al., Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures. 2022. 36: p. 223-247.

[30] Balkrishna, A., et al., A systematic review on traditional, ayurvedic, and herbal approaches to treat solar erythema. 2023. 62(3): p. 322-336.

[31] Chiou, W.J.J.D.R., Severe sunburn triggers the development of skin cancers: non-cumulative/overwhelming uv damages, uva rays, human papillomavirus, indoor/outdoor workers and animal models. 2022. 3(2): p. 1-17.

[32] Matar, D.Y., et al., Skin inflammation with a focus on wound healing. 2023. 12(5): p. 269-287.

[33] Advice, P.C.A.J.S.P.C., Sunburn. 2023.

[34] Bernerd, F., et al., The damaging effects of long UVA (UVA1) rays: a major challenge to preserve skin health and integrity. 2022. 23(15): p. 8243.

[35] Chauhan, A., et al., A REVIEW: SUN PROTECTING FACTOR. YMER – An International Peer-Reviewed Journal, 2023. 22(6): p. 1160-1172.

[36] Pniewska, A. and U.J.A.S. Kalinowska-Lis, A Survey of UV Filters Used in Sunscreen Cosmetics. 2024. 14(8): p. 3302.

[37] Chavda, V.P., et al., Sunscreens: A comprehensive review with the application of nanotechnology. 2023. 86: p. 104720.

[38] Parwaiz, S., M.M.J.B. Khan, and B. Engineering, Recent developments in tuning the efficacy of different types of sunscreens. 2023. 46(12): p. 1711-1727.

[39] Gromkowska-Kępka, K.J., et al., The impact of ultraviolet radiation on skin photoaging—review of in vitro studies. 2021. 20(11): p. 3427-3431.

[40] Song, S., et al., Ultraviolet Light Causes Skin Cell Senescence: From Mechanism to Prevention Principle. 2024: p. 2400090.

[41] Negre-Salvayre, A. and R.J.A. Salvayre, Post-translational modifications evoked by reactive carbonyl species in ultraviolet-A-exposed skin: implication in fibroblast senescence and skin photoaging. 2022. 11(11): p. 2281.

[42] Zargaran, D., et al., Facial skin ageing: Key concepts and overview of processes. 2022. 44(4): p. 414-420.

[43] Zorina, A., et al., Molecular mechanisms of changes in homeostasis of the dermal extracellular matrix: both involutional and mediated by ultraviolet radiation. 2022. 23(12): p. 6655.

[44] Karamanos, N.K., et al., A guide to the composition and functions of the extracellular matrix. 2021. 288(24): p. 6850-6912.

[45] Salminen, A., K. Kaarniranta, and A.J.I.R. Kauppinen, Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin. 2022. 71(7): p. 817-831.

[46] Skopelja-Gardner, S., et al., Acute skin exposure to ultraviolet light triggers neutrophil-mediated kidney inflammation. 2021. 118(3): p. e2019097118.

[47] Eassa, H.A., et al., Current topical strategies for skin-aging and inflammaging treatment: science versus fiction. 2020. 71(5).

[48] Ryšavá, A., J. Vostálová, and A.J.I.J.o.R.B. Rajnochova Svobodova, Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells. 2021. 97(10): p. 1383-1403.

[49] Lee, L.-Y., S.-X.J.I.J.o.D. Liu, and Venereology, Pathogenesis of photoaging in human dermal fibroblasts. 2020. 3(1): p. 37-42.

[50] Papaccio, F., S. Caputo, and B.J.A. Bellei, Focus on the contribution of oxidative stress in skin aging. 2022. 11(6): p. 1121.

[51] Wang, Y.J., et al., Adaptability of melanocytes post ultraviolet stimulation in patients with melasma. 2023. 55(7): p. 680-689.

[52] Pfeifer, G.P.J.G.i. and disease, Mechanisms of UV-induced mutations and skin cancer. 2020. 1(3): p. 99-113.

[53] Gerasymchuk, M., et al., Sex-Dependent Skin Aging and Rejuvenation Strategies. 2023. 3(3): p. 196-223.

[54] DANSHINA, S., A. MARKOV, and H.J.I.J.o.P.R. ACHMAD, Causes, symptoms, diagnosis and treatment of melanoma. 2020. 12(3).

[55] Saud, A., et al., Melanoma metastasis: What role does melanin play? 2022. 48(6): p. 217.

[56] Yardman-Frank, J.M. and D.E.J.E.d. Fisher, Skin pigmentation and its control: From ultraviolet radiation to stem cells. 2021. 30(4): p. 560-571.

[57] Levin-Sparenberg, E., et al., A systematic literature review and meta-analysis describing the prevalence of KRAS, NRAS, and BRAF gene mutations in metastatic colorectal cancer. 2020. 13(5): p. 184.

[58] Ottaviano, M., et al., BRAF gene and melanoma: Back to the future. 2021. 22(7): p. 3474.

[59] Jakhar, N., Exploring DNA Lesion Recognition Mechanisms for Cyclobutane Pyrimidine Dimers and 6-4 Photoproduct by Rad4. 2023, International Institute of Information Technology, Hyderabad.

[60] Chen, L., et al., Regulating tumor suppressor genes: post-translational modifications. 2020. 5(1): p. 90.

[61] Gao, L., et al., Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function. 2021. 57: p. 100770.

[62] Engeland, K.J.C.D. and Differentiation, Cell cycle regulation: p53-p21-RB signaling. 2022. 29(5): p. 946-960.

[63] Nakai, K. and D.J.I.j.o.m.s. Tsuruta, What are reactive oxygen species, free radicals, and oxidative stress in skin diseases? 2021. 22(19): p. 10799.

[64] Eddy, K. and S.J.I.j.o.m.s. Chen, Overcoming immune evasion in melanoma. 2020. 21(23): p. 8984.

[65] Djavid, A.R., et al., Etiologies of melanoma development and prevention measures: A review of the current evidence. 2021. 13(19): p. 4914.

[66] Davis, L.E., et al., Current state of melanoma diagnosis and treatment. 2019. 20(11): p. 1366-1379.

[67] Ahmed, B., M.I. Qadir, and S.J.C.R.i.E.G.E. Ghafoor, Malignant melanoma: skin cancer− diagnosis, prevention, and treatment. 2020. 30(4).

[68] Duarte, A.F., et al., Clinical ABCDE rule for early melanoma detection. 2021. 31(6): p. 771-778.

[69] Demirbaş, A., Ö.F. Elmas, and N. Akdeniz, Benign Neoplasms, in Roxburgh’s Common Skin Diseases. 2022, CRC Press. p. 230-245.

[70] Ralli, M., et al., Immunotherapy in the treatment of metastatic melanoma: current knowledge and future directions. 2020. 2020(1): p. 9235638.

[71] Simiczyjew, A., et al., The influence of tumor microenvironment on immune escape of melanoma. 2020. 21(21): p. 8359.

[72] Lazar, A.M., et al., Skin Malignant Melanoma and Matrix Metalloproteinases: Promising Links to Efficient Therapies. 2024. 25(14): p. 7804.

[73] Csapo, R., M. Gumpenberger, and B.J.F.i.p. Wessner, Skeletal muscle extracellular matrix–what do we know about its composition, regulation, and physiological roles? A narrative review. 2020. 11: p. 253.

[74] Das, V., et al., The basics of epithelial–mesenchymal transition (EMT): A study from a structure, dynamics, and functional perspective. 2019. 234(9): p. 14535-14555.

[75] Jenkins, R.W. and D.E.J.J.o.I.D. Fisher, Treatment of advanced melanoma in 2020 and beyond. 2021. 141(1): p. 23-31.

[76] Czarnecka, A.M., et al., Targeted therapy in melanoma and mechanisms of resistance. 2020. 21(13): p. 4576.

[77] Trojaniello, C., J.J. Luke, and P.A.J.F.i.O. Ascierto, Therapeutic advancements across clinical stages in melanoma, with a focus on targeted immunotherapy. 2021. 11: p. 670726.

[78] Zhang, Z., A. Richmond, and C.J.I.j.o.m.s. Yan, Immunomodulatory properties of PI3K/AKT/mTOR and MAPK/MEK/ERK inhibition augment response to immune checkpoint blockade in melanoma and triple-negative breast cancer. 2022. 23(13): p. 7353.

[79] Šerman, N., et al., Genetic risk factors in melanoma etiopathogenesis and the role of genetic counseling: A concise review. 2022. 22(5): p. 673.

[80] Cives, M., et al., Non-melanoma skin cancers: Biological and clinical features. 2020. 21(15): p. 5394.

[81] Trager, M.H., et al., Biomarkers in melanoma and non-melanoma skin cancer prevention and risk stratification. 2022. 31(1): p. 4-12.

[82] Ciążyńska, M., et al., Ultraviolet radiation and chronic inflammation—Molecules and mechanisms involved in skin carcinogenesis: A narrative review. 2021. 11(4): p. 326.

[83] Toriyama, E., et al., Time kinetics of cyclobutane pyrimidine dimer formation by narrowband and broadband UVB irradiation. 2021. 103(3): p. 151-155.

[84] Organization, W.H., The effect of occupational exposure to solar ultraviolet radiation on malignant skin melanoma and non-melanoma skin cancer: a systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury. 2021.

[85] Bernard, J.J., R.L. Gallo, and J.J.N.R.I. Krutmann, Photoimmunology: how ultraviolet radiation affects the immune system. 2019. 19(11): p. 688-701.

[86] Ciążyńska, M., et al., The incidence and clinical analysis of non-melanoma skin cancer. 2021. 11(1): p. 4337.

[87] Tan, S.T., et al., Basal cell carcinoma arises from interfollicular layer of epidermis. 2018. 2018(1): p. 3098940.

[88] Teng, Y., et al., Ultraviolet radiation and basal cell carcinoma: an environmental perspective. 2021. 9: p. 666528.

[89] Farooqi, A.A., et al. Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights. in Seminars in cancer biology. 2019. Elsevier.

[90] Bunker, C. and R. Watchorn, Skin disease, in Medicine for Finals and Beyond. 2022, CRC Press. p. 611-656.

[91] Stundys, D., et al., The quality of life in surgically treated head and neck basal cell carcinoma patients: A comprehensive review. 2023. 15(3): p. 801.

[92] Niculet, E., et al., Basal cell carcinoma: Comprehensive clinical and histopathological aspects, novel imaging tools and therapeutic approaches. 2022. 23(1): p. 1-8.

[93] Walker, H.S. and J.J.S. Hardwicke, Non-melanoma skin cancer. 2022. 40(1): p. 39-45.

[94] Broders, A.C.J.A.o.s., SQUAMOUS–CELL EPITHELIOMA OF THE SKIN: A STUDY OF 256 CASES. 1921. 73(2): p. 141.

[95] Feller, L., et al., Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face. 2016. 12: p. 1-7.

[96] Ackerman, A. and J.J.B.J.o.D. Mones, Solar (actinic) keratosis is squamous cell carcinoma. 2006. 155(1): p. 9-22.

[97] Nathan, C.A., et al., TP53 mutations in head and neck cancer. 2022. 61(4): p. 385-391.

[98] Pillai, S., L. Johnson, and H.J.J.N.R.P.S.P. Bagde, Squamous cell carcinoma: a comprehensive review on causes, clinical presentation, diagnosis, prognosis, and prevention. 2023. 3(02): p. 21-26.

[99] Bhambri, S., S. Dinehart, and A.J.C.o.t.s.E. Bhambri, Squamous cell carcinoma. 2011. 2: p. 124-139.

[100] Bichakjian, C., et al., Guidelines of care for the management of basal cell carcinoma. 2018. 78(3): p. 540-559.

[101] Ahad, T., S. Kalia, and H. Lui, Topical, Ablative and Light-Based Therapies for Non-Melanoma Skin Neoplasms, in Non-melanoma Skin Cancer. 2023, CRC Press. p. 123-136.

[102] Chang, D.F. and B. Lee, Cataracts: A Patient’s Guide to Treatment. 2024: CRC Press.

[103] Kamari, F., et al., Phototoxicity of environmental radiations in human lens: Revisiting the pathogenesis of UVinduced cataract. 2019. 257: p. 2065-2077.

[104] Pajer, V., Age-related UV absorption of the human eye lens andits molecular background. 2020, Szegedi Tudomanyegyetem (Hungary).

[105] Chen, L.-J., et al., Relationship between practices of eye protection against solar ultraviolet radiation and cataract in a rural area. 2021. 16(7): p. e0255136.

[106] Ivanov, I.V., et al., Ultraviolet radiation oxidative stress affects eye health. 2018. 11(7): p. e201700377.

[107] Hanafy, B.I., Formulation of cerium oxide nanoparticles towards the prevention and treatment of cataract. 2020: Nottingham Trent University (United Kingdom).

[108] Borges-Rodríguez, Y., et al., Effect of the ultraviolet radiation on the lens. 2023. 24(3): p. 215-228.

[109] Serebryany, E., et al., A native chemical chaperone in the human eye lens. 2022. 11: p. e76923.

[110] Chowdhury, A., et al., p-Benzoquinone-induced aggregation and perturbation of structure and chaperone function of α-crystallin is a causative factor of cigarette smoke-related cataractogenesis. 2018. 394: p. 11-18.

[111] Richardson, R.B., et al., Etiology of posterior subcapsular cataracts based on a review of risk factors including aging, diabetes, and ionizing radiation. 2020. 96(11): p. 1339-1361.

[112] Maltry, A.C. and J.D. Cameron, Pathology of the Lens, in Albert and Jakobiec’s Principles and Practice of Ophthalmology. 2022, Springer. p. 6083-6130.

[113] Ambarsari, P.J.J.o.I.D.S.S., Expert System Detection of Cataract Using Production Rules. 2020. 3(1): p. 27-33.

[114] Ćurić, M., et al., Sunlight and Health. 2022: p. 121-141.

[115] Volatier, T., et al., UV protection in the cornea: failure and rescue. 2022. 11(2): p. 278.

[116] Dammak, A., et al., Oxidative stress in the anterior ocular diseases: diagnostic and treatment. 2023. 11(2): p. 292.

[117] Izadi, M., et al., Photokeratitis induced by ultraviolet radiation in travelers: A major health problem. 2018. 64(1): p. 40-46.

[118] Hamba, N., A. Gerbi, and S.J.T.R.i.A. Tesfaye, Histopathological effects of ultraviolet radiation exposure on the ocular structures in animal studies–literature review. 2021. 22: p. 100086.

[119] Leitman, M.W., Manual for eye examination and diagnosis. 2021: John Wiley & Sons.

[120] Jaki Mekjavic, P., M.J. Tipton, and I.B.J.E.p. Mekjavic, The eye in extreme environments. 2021. 106(1): p. 52-64.

[121] Robinson, J., R. Begum, and M.J.A.I.t.N.-I.R. Maqbool, Ultraviolet Radiation: Benefits, Harms, Protection. 2023. 2: p. 62.

[122] Ziaei, M., C. Greene, and C.R.J.A.d.d.r. Green, Wound healing in the eye: therapeutic prospects. 2018. 126: p. 162-176.

[123] Bais, A.F., et al., Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017. 2018. 17(2): p. 127-179.

[124] Hart, P.H., M.J.P. Norval, and p. sciences, Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis. 2018. 17(12): p. 1872-1884.

[125] Kamenisch, Y., et al., UVA, metabolism and melanoma: UVA makes melanoma hungry for metastasis. 2018. 27(9): p. 941-949.

[126] Tse, B.C., S.N.J.P. Byrne, and P. Sciences, Lipids in ultraviolet radiation-induced immune modulation. 2020. 19: p. 870-878.

[127] Yu, Z.-w., et al., Ultraviolet (UV) radiation: a double-edged sword in cancer development and therapy. 2024. 5(1): p. 1-24.

[128] Premjit, Y., S. Pandey, and J.J.F.R.I. Mitra, Recent trends in folic acid (vitamin B9) encapsulation, controlled release, and mathematical modelling. 2023. 39(8): p. 5528-5562.

[129] Virdi, S. and N.M.J.M. Jadavji, The impact of maternal folates on brain development and function after birth. 2022. 12(9): p. 876.

[130] Liang, L.J.J.o.A. and F. Research, Folates: stability and interaction with biological molecules. 2020. 2: p. 100039.

[131] Bo, Y., et al., Association between folate and health outcomes: an umbrella review of meta-analyses. 2020. 8: p. 550753.

[132] Alaee, S., Air Pollution and Infertility. Journal of Environmental Treatment Terchniques, 2018. 6(4): p. 72-73.

[133] Khodabandeh, Z., et al., Protective Effect of Quercetin on Testis Structure and Apoptosis Against Lead Acetate Toxicity: an Stereological Study. Biol Trace Elem Res, 2021. 199(9): p. 3371-3381.

[134] Lotfy, M., et al., Destructive effects of UVC radiation on Drosophila melanogaster: Mortality, fertility, mutations, and molecular mechanisms. 2024. 19(5): p. e0303115.

[135] Szumiel, I.J.I.j.o.r.b., Ionizing radiation-induced oxidative stress, epigenetic changes and genomic instability: the pivotal role of mitochondria. 2015. 91(1): p. 1-12.

[136] Aldoury, R.S.M.J.I.J.f.R.i.A.S. and Biotechnology, A Review Article: Effect of Radiation on Infertility. 2022. 9(1): p. 45-65.

[137] Srivasatav, S., et al., Impact of radiation on male fertility, in Oxidative Stress and Toxicity in Reproductive Biology and Medicine: A Comprehensive Update on Male Infertility Volume II. 2022, Springer. p. 71-82.

[138] Mohammadi, Z., et al., The antioxidant properties of resveratrol on sperm parameters, testicular tissue, antioxidant capacity, and lipid peroxidation in isoflurane-induced toxicity in mice. Hum Exp Toxicol, 2023. 42: p. 9603271231215036.

[139] Nowicka-Bauer, K. and B.J.A. Nixon, Molecular changes induced by oxidative stress that impair human sperm motility. 2020. 9(2): p. 134.

[140] Torres, E.R., et al., Effect of ultraviolet C irradiation on human sperm motility and lipid peroxidation. 2010. 86(3): p. 187-193.

[141] Da Costa, R., et al., Spectral features of nuclear DNA in human sperm assessed by Raman Microspectroscopy: Effects of UV-irradiation and hydration. 2018. 13(11): p. e0207786.

[142] Akbarzadeh-Jahromi, M., et al., Evaluation of supplementation of cryopreservation medium with gallic acid as an antioxidant in quality of post-thaw human spermatozoa. 2022. 54(11): p. e14571.

[143] Jangid, P., et al., The role of non-ionizing electromagnetic radiation on female fertility: A review. 2023. 33(4): p. 358-373.

[144] Alaee, S., et al., Curcumin mitigates acrylamide-induced ovarian antioxidant disruption and apoptosis in female Balb/c mice: A comprehensive study on gene and protein expressions. Food Sci Nutr, 2024. 12(6): p. 4160-4172.

[145] Alaee, S., et al., Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model. Vet Med Sci, 2023. 9(1): p. 290-300.

[146] Mantawy, E.M., et al., Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: emphasis on TGF-β/MAPKs signaling pathway. 2019. 109: p. 293-303.

[147] Gao, W., et al., The protective effect of N-acetylcysteine on ionizing radiation induced ovarian failure and loss of ovarian reserve in female mouse. 2017. 2017(1): p. 4176170.

[148] Ozaltin, S., et al., Are antral follicle count and serum anti-Mullerian hormone level, as reliable markers of ovarian reserve, affected by UV radiation? 2022. 38(8): p. 639-643.

[149] Zaha, I., et al., The Role of Oxidative Stress in Infertility. 2023. 13(8): p. 1264.

[150] Sinha, R.P., D.-P.J.P. Häder, and P. Sciences, UV-induced DNA damage and repair: a review. 2002. 1(4): p. 225-236.

[151] König, K., et al., Andrology: Effects of ultraviolet exposure and near infrared laser tweezers on human spermatozoa. 1996. 11(10): p. 2162-2164.

[152] Petruk, G., et al., Antioxidants from plants protect against skin photoaging. 2018. 2018(1): p. 1454936.

[153] Yaghutian Nezhad, L., et al., Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice. Hum Exp Toxicol, 2021. 40(12_suppl): p. S611-S621.

[154] Dara, M., et al., “Effect of Sunset Yellow on Testis: Molecular Evaluation, and Protective Role of Coenzyme Q10 in Male Sprague-Dawley Rats”. Cell Biochem Biophys, 2024. 82(3): p. 2827-2835.

[155] Nayar, K.D., et al., Unveiling the Link: Investigating the Environmental Factors and Lifestyle Contributing to Infertility. 2023. 11(2): p. 38-49.

[156] Sachdev, S., et al., Abiotic stress and reactive oxygen species: Generation, signaling, and defense mechanisms. 2021. 10(2): p. 277.

[157] Bakhtari, A., et al., Effects of Dextran-Coated Superparamagnetic Iron Oxide Nanoparticles on Mouse Embryo Development, Antioxidant Enzymes and Apoptosis Genes Expression, and Ultrastructure of Sperm, Oocytes and Granulosa Cells. Int J Fertil Steril, 2020. 14(3): p. 161-170.

[158] Chianese, R. and R. Pierantoni Mitochondrial Reactive Oxygen Species (ROS) Production Alters Sperm Quality. Antioxidants, 2021. 10, DOI: 10.3390/antiox10010092.

[159] Vargas-Mendoza, N., et al. Antioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise. Antioxidants, 2019. 8, DOI: 10.3390/antiox8060196.

[160] Ansary, T.M., et al. Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. International Journal of Molecular Sciences, 2021. 22, DOI: 10.3390/ijms22083974.

[161] Ning, B., et al., Degradation of endocrine disrupting chemicals by ozone/AOPs. 2007. 29(3): p. 153-176.

[162] Triebner, K., et al., Ultraviolet radiation as a predictor of sex hormone levels in postmenopausal women: A European multi-center study (ECRHS). 2021. 145: p. 49-55.

[163] Ferrara, F., et al., Evaluating the effect of ozone in UV induced skin damage. 2021. 338: p. 40-50.

[164] Akhtar, M., et al., Upregulated-gene expression of pro-inflammatory cytokines (TNF-α, IL-1β and IL-6) via TLRs following NF-κB and MAPKs in bovine mastitis. 2020. 207: p. 105458.

[165] Ahmadi, H., et al., Composition and effects of seminal plasma in the female reproductive tracts on implantation of human embryos. 2022. 151: p. 113065.

[166] Rasheed, H.A.M. and P.J.C. Hamid, Inflammation to infertility: panoramic view on endometriosis. 2020. 12(11).

[167] Vertika, S., K.K. Singh, and S.J.M. Rajender, Mitochondria, spermatogenesis, and male infertility–an update. 2020. 54: p. 26-40.

[168] Silva, T.D., et al., Metabolic dysregulations underlying the pulmonary toxicity of atmospheric fine particulate matter: focus on energy-producing pathways and lipid metabolism. 2022. 15(11): p. 2051-2065.

[169] Valacchi, G., et al., MicroRNA Alterations Induced in Human Skin by Diesel Fumes, Ozone, and UV Radiation. 2022. 12(2): p. 176.

[170] Sciorio, R. and S.C.J.J.o.C.M. Esteves, Contemporary use of ICSI and epigenetic risks to future generations. 2022. 11(8): p. 2135.

[171] Zhang, X., et al., Epigenetic memory and growth responses of the clonal plant Glechoma longituba to parental recurrent UV-B stress. 2021. 48(8): p. 827-838.

[172] Soesanti, F., Early life exposure to environmental hazards and infant health. 2024, Utrecht University.

[173] Pirow, R., et al., Mono-n-hexyl phthalate: exposure estimation and assessment of health risks based on levels found in human urine samples. 2024. 98(11): p. 3659-3671.

[174] Mishra, A., Know Your Sunscreen. International Journal For Multidisciplinary Research, 2024. 6(4): p. 1-6.

[175] Sonwanee, D. and T. Sahu, Current Understanding of the Effects of Sun Exposure on Skin Tanning: Mechanisms, Risks, and Protective Strategies. International Journal For Multidisciplinary Research, 2023. 5(3): p. 1-18.

[176] Raymond-Lezman, J.R. and S.I.J.C. Riskin, Benefits and risks of sun exposure to maintain adequate vitamin D levels. 2023. 15(5).

[177] Soundharaj, S., et al., The role of ultraviolet radiation in human race. 2022. 1(2): p. 48-56.

[178] Mohsin, B.B., S.A.K.J.J.o.E. Ali, and S. Development, EFFECT OF ULTRAVIOLET ON OUTDOOR WORKERS. 2022. 26(2): p. 94-102.

[179] Mujtaba, S.F., et al., Oxidative-stress-induced cellular toxicity and glycoxidation of biomolecules by cosmetic products under sunlight exposure. 2021. 10(7): p. 1008.

[180] Miligi, L., Ultraviolet radiation exposure: some observations and considerations, focusing on some Italian experiences, on cancer risk, and primary prevention. 2020, MDPI.

[181] Olarte Saucedo, M., et al., Efecto de la radiación ultravioleta (UV) en animales domésticos. Revisión. 2019. 10(2): p. 416-432.