International Journal of Reproductive BioMedicine

ISSN: 2476-3772

The latest discoveries in all areas of reproduction and reproductive technology.

 

The comparison of predictive value of cervical length in singleton spontaneous preterm labor with in vitro fertilization pregnancies: A cohort study

Published date: Jan 25 2021

Journal Title: International Journal of Reproductive BioMedicine

Issue title: International Journal of Reproductive BioMedicine (IJRM): Volume 19, Issue No. 1

Pages: 57–62

DOI: 10.18502/ijrm.v19i1.8180

Authors:

Razieh MohammadFertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mahvash ZargarFertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mojgan BaratiFertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Somayeh Ershadiandr.ershadian@gmail.comFertility Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Abstract:

Background: Preterm labor (PTL) is one of the most important factors in neonatal mortality. Some studies have revealed a reverse relationship between cervical length (CL) and PTL, however, further evidence is needed to confirm it.

Objective: To investigate the predictive value of CL in spontaneous and in vitro fertilization (IVF) pregnancies.

Materials and Methods: This prospective cohort study was performed on 154 pregnant women from 16-26 wk of gestation with a singleton fetus in spontaneous delivery (n = 77) and IVF pregnancies (n = 77) and followed up until delivery. Women with multiple pregnancy, placenta previa, cerclage, and congenital anomalies were excluded from the study. The cut-off determination was done according to the Roc analysis.

Results: The mean CL in term delivery and PTL groups were 37 ± 7 mm and 31 ± 6 mm, respectively (p < 0.001). The frequency of PTL in spontaneous and IVF pregnancies were 7.8% and 23.27%, respectively (p = 0.007). According to the Roc analysis, the best cut-off for normal pregnancy was ≤ 36 mm with the negative predictive value of 97.9%, the positive predictive value of 11.4%, sensitivity 83.3%, and specificity of 46.5%. While for the IVF group, the cut off was ≤ 30 mm, with a negative predictive value of 88.4%, a positive predictive value of 57.8%, sensitivity of 63.2%, and a specificity of 86%.

Conclusion: In this study, IVF had a significant direct correlation with PTL. CL also had a significant indirect relationship with PTL.

Key words: Cervix, IVF, Preterm delivery, PTL.

References:

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