International Journal of Reproductive BioMedicine

ISSN: 2476-3772

The latest discoveries in all areas of reproduction and reproductive technology.

 

Carotid artery intima-media thickness in women with polycystic ovary syndrome: A cross-sectional study

Published date: Nov 10 2024

Journal Title: International Journal of Reproductive BioMedicine

Issue title: International Journal of Reproductive BioMedicine (IJRM): Volume 22, Issue No. 9

Pages: 749–754

DOI: 10.18502/ijrm.v22i9.17480

Authors:

Nazanin FarshchianNfarshchian@kums.ac.irRadiology Department, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Parisa Bahrami KamangarRadiology Department, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Mohammad Reza GhasempourRadiology Department, Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract:

Background: Obesity in polycystic ovary syndrome (PCOS) may increase the risk of cardiovascular disease. Carotid intima-media thickness (CIMT) is an acceptable marker in assessing the risk of heart disease.

Objective: This study aimed to evaluate the CIMT in PCOS women compared to non-PCOS women.

Materials and Methods: This cross-sectional study was conducted on 48 women who referred to Imam Reza hospital, Kermanshah, Iran from July 2020–2021. Women were divided into 2 groups of PCOS and non-PCOS women (n = 24/each). The intima-media thickness of participants’ carotid artery was measured on both sides in 3 areas, and its mean was recorded.

Results: The mean thickness of the carotid artery intima-media in the case group was within the normal range; but it was significantly higher than the control group (0.71 ± 0.17 vs. 0.57 ± 0.09 mm, p = 0.019).

Conclusion: Considering the higher thickness of CIMT in women with PCOS, it can be concluded that PCOS increases the risk of heart diseases in women.

Key words: Polycystic ovary disease, Atherosclerosis, Intima media thickness, Carotid artery, Cardiovascular disease.

References:

[1] Frouhari S, Heidari Zh, Tavana Z, Mihanpour H, Sayadi M, Shayan A, et al. [Effect of some hormones related to polycystic ovary syndrome on health-related quality of life]. Iran J Obstet Gynecol Infertil 2016; 18: 17–27. (in Persian).

[2] Trikudanathan S. Polycystic ovarian syndrome. Med Clin North Am 2015; 99: 221–235.

[3] Akbari Nasrekani Z, Fathi M. [Efficacy of 12 weeks aerobic training on body composition, aerobic power and some women-hormones in polycystic ovary syndrome infertile women]. Iran J Obstet Gynecol Infertil 2016; 19: 1–10. (in Persian).

[4] Morris S, Grover S, Sabin MA. What does a diagnostic label of ‘polycystic ovary syndrome’ really mean in adolescence? A review of current practice recommendations. Clin Obes 2016; 6: 1–8.

[5] Hussain A. Polycystic ovary syndrome-diagnosis and treatment. [Master’s Thesis]. Norway: University of Oslo; 2015.

[6] Jonard S, Robert Y, Cortet-Rudelli C, Pigny P, Decanter C, Dewailly D. Ultra-sound examination of polycystic ovaries: Is it worth counting the follicles? Hum Reprod 2003; 18: 598–603.

[7] Farshchian N, Fakheri T, Hezbi A. A comparison of color doppler sonography findings in polycystic ovarian syndrome patients and healthy women. J Babol Univ Med Sci 2015; 17: 61–66.

[8] Deans R. Polycystic ovary syndrome in adolescence. Med Sci 2019; 7: 101.

[9] Deswal R, Narwal V, Dang A, Pundir ChS. The prevalence of polycystic ovary syndrome: A brief systematic review. J Hum Reprod Sci 2020; 13: 261–271.

[10] Sayehmiri F, Kiani F, Sayehmiri K, Maleki F, Ahmadi M, Shohani M. [Prevalence of polycystic ovary syndrome in Iranian women: A systematic review and meta-analysis]. Iran J Obstet Gynecol Infertil 2014; 17: 11–21. (in Persian)

[11] Singh S, Pal N, Shubham S, Sarma DK, Verma V, Marotta F, et al. Polycystic ovary syndrome: Etiology, current management, and future therapeutics. J Clin Med 2023; 12: 1454.

[12] Nandi A, Chen Z, Patel R, Poretsky L. Polycystic ovary syndrome. Endocrinol Metab Clin North Am 2014; 43: 123–147.

[13] Bereda G. Risk factors of atherosclerosis. J Vasc Surg 2022; 10: 1000444.

[14] Fishbein MC, Fishbein GA. Arteriosclerosis: Facts and fancy. Cardiovasc Pathol 2015; 24: 335–342.

[15] Katakami N, Matsuoka T, Shimomura I. Clinical utility of carotid ultrasonography: Application for the management of patients with diabetes. J Diabetes Investig 2019; 10: 883–898.

[16] Buyukkaya R, Besir FH, Yazgan S, Karatas A, Kose SA, Aydin Y, et al. The evaluation of carotid intima-media thickness and visceral obesity as an atherosclerosis predictor in newly-diagnosed polycystic ovary syndrome. Clin Ter 2014; 165: 6–11.

[17] Tripathy P, Sahu A, Sahu M, Nagy A. Ultrasonographic evaluation of intra-abdominal fat distribution and study of its influence on subclinical atherosclerosis in women with polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol 2017; 217: 18–22.

[18] Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod 2004; 19: 41–47.

[19] Allameh Z, Rouholamin S, Adibi A, Mehdipour M, Adeli M. Does carotid intima-media thickness have relationship with polycystic ovary syndrome? Int J Prev Med 2013; 4: 1266–1270.

[20] Jabbour R, Ott J, Eppel W, Frigo P. Carotid intima-media thickness in polycystic ovary syndrome and its association with hormone and lipid profiles. PLoS One 2020; 15: e0232299.

[21] Karoli R, Fatima J, Siddiqi Z, Vatsal P, Sultania AR, Maini S. Study of early atherosclerotic markers in women with polycystic ovary syndrome. Indian J Endocrinol Metab 2012; 16: 1004–1008.

[22] Rahmanpoor H, Ghorbani M, Azarkhish K, Mazloomi S, Kolifarhood G, Forghani F. [Evaluation of carotid atherosclerosis in polycystic ovary syndrome: A case-control study in Zanjan, Iran]. J Zabol Univ Med Sci 2014; 3: 88–96. (in Persian)

[23] Rosenberg SL. The relationship between PCOS and obesity: Which comes first? Sci J Lander College Arts Sci 2019; 13: 34–40.

[24] Pillay P, Carter J, Taylor H, Lewington S, Clarke R. Independent relevance of different measures of adiposity for carotid intima-media thickness in 40 000 adults in UK biobank. J Am Heart Assoc 2023; 12: e026694.

[25] Peppa M, Koliaki C, Nikolopoulos P, Raptis SA. Skeletal muscle insulin resistance in endocrine disease. J Biomed Biotechnol 2010; 2010: 13.

[26] Cesaro A, Michele GD, Fimiani F, Acerbo V, Scherillo G, Signore G, et al. Visceral adipose tissue and residual cardiovascular risk: A pathological link and new therapeutic options. Front Cardiovasc Med 2023; 10: 1187735.

[27] Kim MS, Dao-Tran A, Davidowitz E, Tseng T, Gilsanz V, Ryabets-Lienhard A, et al. Carotid intima-media thickness is associated with increased androgens in adolescents and young adults with classical congenital adrenal hyperplasia. Horm Res Paediatr 2016; 85: 242–249.

[28] Kaur H, Tiwari P, Sharma S, Verma M. An analytical cross-sectional study to assess the effects of smoking on common carotid intima-media thickness and resistivity index among current smokers. J Diagn Med Sonography 2022; 38: 26–34.

[29] Zhang L, Fan F, Qi L, Jia J, Yang Y, Li J, et al. The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population. BMC Cardiovasc Disord 2019; 19: 269.

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