International Journal of Reproductive BioMedicine
ISSN: 2476-3772
The latest discoveries in all areas of reproduction and reproductive technology.
The effect of platelet-rich plasma on the improvement of pregnancy results in repeated implantation failure: A randomized controlled trial
Published date: Oct 12 2022
Journal Title: International Journal of Reproductive BioMedicine
Issue title: International Journal of Reproductive BioMedicine (IJRM): Volume 20, Issue No. 9
Pages: 753–760
Authors:
Abstract:
Background: The success rate of infertility treatment depends on many different factors.
Objective: This study aimed to determine the effect of platelet-rich plasma (PRP) on the improvement of pregnancy outcomes in participants with repeated implantation failure.
Materials and Methods: The study is a randomized triple-blind clinical trial. The study population was 118 women with repeated implantation failure during assisted reproductive technology treatment at Tabriz Jihad-e Daneshgahi ART Center from May 2017 to December 2019. Intervention: Intrauterine injection of autologous PRP. Standard treatment of fetal transfer to the uterine cavity was performed without intrauterine PRP injection in the control group: After 4 wk, the level of β-human chorionic gonadotropin hormone in participants’ blood was measured.
Results: Comparing the effect of intrauterine injection of PRP in 2 groups showed the level of β-human chorionic gonadotropin positive in the intervention group was 21 (43.8%), in the control group was 12 (26.1%), odds ratio = 2.20 (0.92-5.26) and p = 0.073.
Conclusion: The therapeutic effect in the intervention group compared to the control regarding the outcome of a successful pregnancy showed that intrauterine injection of PRP can be effective in improving pregnancy outcomes, although this improvement is not significant.
Key words: Platelet-rich plasma, Pregnancy results, Embryo implantation.
References:
[1] Timeva T, Shterev A, Kyurkchiev S. Recurrent implantation failure: he role of the endometrium. J Reprod Infertil 2014; 15: 173-183.
[2] Nazari L, Salehpour S, Hoseini S, Zadehmodarres S, Ajori L. Effects of autologous platelet-rich plasma on implantation and pregnancy in repeated implantation failure: A pilot study. Int J Reprod BioMed 2016; 14: 625- 628.
[3] Choi Y, Kim HR, Lim EJ, Park M, Yoon JA, Kim YS. Integrative analyses of uterine transcriptome and microRNAome reveal compromised LIF- STAT3 signaling and progesterone response in the endometrium of patients with recurrent/repeated implantation failure (RIF). PloS One 2016; 11: e0157696.
[4] Katzorke N, Vilella F, Ruiz M, Krüssel JS, Simon C. Diagnosis of endometrial-factor infertility: Current
approaches and new avenues for research. Geburtshilfe Frauenheilkunde 2016; 76: 699-703.
[5] Cavalcante MB, Costa FD, Barini R, Júnior EA. Granulocyte colony-stimulating factor and reproductive medicine: A review. Iran J Reprod Med 2015; 13: 195- 202.
[6] Dhillon RS, Schwarz EM, Maloney MD. Platelet-rich plasma therapy-future or trend? Arthritis Res Ther 2012; 14: 219.
[7] Farimani M, Bahmanzadeh M, Poorolajal J. A new approach using autologous platelet-rich plasma (PRP) to treat infertility and to improve population replacement rate. J Res Health Sci 2016; 16: 172-173.
[8] Mehrafza M, Kabodmehri R, Nikpouri Z, Pourseify G, Raoufi A, Eftekhari A, et al. Comparing the impact of autologous platelet-rich plasma and granulocyte colony stimulating factor on pregnancy outcome in patients with repeated implantation failure. J Reprod Infertil 2019; 20: 35-41.
[9] Coksuer H, Akdemir Y, Ulas Barut M. Improved in vitro fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history. Gynecol Endocrinol 2019; 35: 815-818.
[10] Maleki-Hagiagha A, Razavi M, Rouholamin S, Rezaeinejad M, Maroufizadeh S, Sepidarkish M. Intrauterine infusion of autologous platelet rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis. J Reprod Immunol 2020; 137: 103078.