International Journal of Reproductive BioMedicine

ISSN: 2476-3772

The latest discoveries in all areas of reproduction and reproductive technology.

 

Male factor testing in recurrent pregnancy loss cases: A narrative review

Published date: Jul 06 2022

Journal Title: International Journal of Reproductive BioMedicine

Issue title: International Journal of Reproductive BioMedicine (IJRM): Volume 20, Issue No. 6

Pages: 447-460

DOI: 10.18502/ijrm.v20i6.11440

Authors:

Soheila PourmasumiSocial Determinants of Health Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Parvin SabetiDepartment of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Nasrin Ghaseminghasemi479@gmail.comAbortion Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Abstract:

Recurrent pregnancy loss is a distinct disorder defined as the loss of at least 2 pregnancies before the 20th wk of gestation. With half of the genome of the embryo belonging to the father, the integrity of the sperm genome is crucial for a successful pregnancy. Semen analysis is recommended for men in such cases to evaluate sperm concentration, morphology, vitality and motility. However, other important sperm parameters such as sperm epigenetics, aneuploidy, Y chromosome microdeletion and chromatin integrity also correlate with successful pregnancy and delivery rate. This article examines the use of different sperm tests and their importance in male partners of women suffering from recurrent pregnancy loss.

Key words: DNA fragmentation, Sperm, Y chromosome, Recurrent pregnancy loss.

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