Published date: Jun 08 2022

Journal Title: International Journal of Reproductive BioMedicine

Issue title: International Journal of Reproductive BioMedicine (IJRM): Volume 20, Issue No. 5

Pages: 405-412

DOI: 10.18502/ijrm.v20i5.11055

Mohammad Reza AlipourYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Hossein MoradiShahid Sadoughi University of Medical Sciences, Yazd, Iran.

Seyedeh Mahdieh NamayandehYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Fatemeh MajidpoureYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Zohreh Pezeshkpourz.pezeshkpour@yahoo.comResearch and Clinical Center Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mohammadtaghi SarebanhasanabadiYazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Background: Congenital cardiovascular malformation is the most common group of birth defects. Fetal echocardiography is highly sensitive and specific in the diagnosis of congenital heart disease in low- and high-risk populations.

Objective: This study aimed to assess abnormal findings in fetal echocardiography and maternal disease.

Materials and Methods: This cross-sectional study was performed on 114 pregnant women referred to Afshar hospital, Yazd, Iran from October 2016 to March 2017. All pregnant women underwent fetal echocardiography through fetal heart screening protocol, which is administered by the international society of ultrasound in obstetrics and gynecology guidelines. Data collected included referral cause, gestational age, maternal age, gravida, and final diagnosis after an accurate fetal echocardiography.

Results: The mean gestational age was 20 wk. The most common referral cause of pregnant women included diabetes (36.8%), fetal arrhythmia (14%), high maternal age (7%), and echogenic focus on ultrasound (6.1%). The most common postpartum findings were normal (68.4%), cardiac abnormalities (17.6%), and arrhythmias (14%). In postnatal echocardiography, the results were consistent with fetal echocardiography except in 2 women.

Conclusion: This study showed that fetal echocardiography can be used in the early diagnosis and treatment of congenital heart diseases.

Key words: Fetus, Echocardiography, Heart defects, Congenital.

[1] Loscalzo J. Harrison’s Cardiovascular Medicine 2/E. 3rd Ed. New York: McGraw-Hill Education; 2013.

[2] Nelson LS, Hoffman RS, Howland MA, Lewin NA, Goldfrank LR. Goldfrank’s toxicologic emergencies. New York: McGraw Hill Professional; 2018.

[3] Hoffman J. Incidence, mortality and natural history. In: Anderson RH, Macortney FJ, Shinebourne EA. All pediatric cardiology. London: Churchill Livinstone; 1997.

[4] Sharma Sh, Kaur N, Kaur Kh, Pawar NCh. Role of echocardiography in prenatal screening of congenital heart diseases and its correlation with postnatal outcome. J Clin Diagn Res 2017; 11: TC12–TC14.

[5] Buskens E, Grobbee DE, Frohn-Mulder IM, Wladimiroff JW, Hess J. Aspects of the aetiology of congenital heart disease. Eur Heart J 1995; 16: 584–587.

[6] Hoffman RS, Howland MA, Lewin NA, Nelson LS, Goldfrank LR. Goldfrank’s toxicologic emergencies. New York: McGraw Hill Professional; 2014.

[7] Hunter LE, Seale AN. Educational series in congenital heart disease: Prenatal diagnosis of congenital heart disease. Echo Res Pract 2018; 5: R81–R100.

[8] Chu Ch, Yan Y, Ren Y, Li X, Gui Y. Prenatal diagnosis of congenital heart diseases by fetal echocardiography in second trimester: A Chinese multicenter study. Acta Obstet Gynecol Scand 2017; 96: 454–463.

[9] Alves deRocha L, Júnior EA, Marcondes Machado Nardozz L, Fernandes Moron A. Screening of fetal congenital heart disease: The challenge continues. Rev Bras Cir Cardiovasc 2013; 28: V–VII.

[10] Fouron JC, Proulx F, Miró J, Gosselin J. Doppler and M-mode ultrasonography to time fetal atrial and ventricular contractions. Obstet Gynecol 2000; 96: 732–736.

[11] Jaeggi E, Fouron JC, Fournier A, van Doesburg N, Drblik SP, Proulx F. Ventriculo-atrial time interval measured on M-mode echocardiography: A determining element in diagnosis, treatment, and prognosis of fetal supraventricular tachycardia. Heart 1998; 79: 582–587.

[12] Mosaed P. Fetal echocardiography; Introduction and approaches. Sarem J Reprod Med 2018; 2: 31–34.

[13] Nayak K, Naveen Chandra GS, Shetty R, Narayan PK. Evaluation of fetal echocardiography as a routine antenatal screening tool for detection of congenital heart disease. Cardiovasc Diagn Ther 2016; 6: 44–49.

[14] Barsoom MJ, Feldman DM, Borgida AF, Esters D, Diana D, Egan J. Is an isolated fetal cardiac echogenic focus an indication for fetal echocardiography? J Ultrasound Med 2001; 20: 1043–1046.

[15] Ghiasi SS, Mottaghi Moghaddam Shahri H, Heidari E. Fetal echocardiography indications: A single-center experience. Int J Pediatr 2019; 7: 8969–8976.

[16] Chitra N, Vijayalakshmi IB. Fetal echocardiography for early detection of congenital heart diseases. J Echocardiogr 2017; 15: 13–17.

[17] Rakha S, El Marsafawy H. Sensitivity, specificity, and accuracy of fetal echocardiography for high-risk pregnancies in a tertiary center in Egypt. Arch Pédiatr 2019; 26: 337–341.

[18] Stümpflen I, Stümpflen A, Wimmer M, Bernaschek G. Effect of detailed fetal echocardiography as part of routine prenatal ultrasonographic screening on detection of congenital heart disease. Lancet 1996; 348: 854–857.