Published date: Sep 09 2021

Journal Title: ESPOCH Congresses: The Ecuadorian Journal of S.T.E.A.M.

Issue title: Volume 1, Issue 6

Pages: 1480–1490

DOI: 10.18502/espoch.v1i6.9636

Iván Enrique Naranjo Logroñonaranjometropolitana@hotmail.comCarrera de Medicina, Facultad de Salud Pública, ESPOCH, Riobamba, Chimborazo, Ecuador

Anthony Alfonso Naranjo CoronelMédico Cirujano, COLPOMED Centro, Hospital del Día, Riobamba, Chimborazo, Ecuador

Ashley Carolina Cuzco MacíasCarrera de Medicina, Facultad de Salud Pública, ESPOCH, Riobamba, Chimborazo, Ecuador

Alison Tamara Ruiz ChicoCarrera de Medicina, Facultad de Salud Pública, ESPOCH, Riobamba, Chimborazo, Ecuador

Introduction: Nutrigenomics explores and defines the rapidly evolving field of interactions in the diet and genome, through the use of nutrition, proteomics, physiology, biochemistry and epigenomics to seek and explain the mutual interactions between genes and nutrients from a molecular approach. Objective: To summarize the evidence of the impact that bioactive compounds of food exerts on epigenetic events aimed primarily at disease prevention. Methods: A literature review was carried out on the main bioactive compounds of food as epigenetic regulators, in the following search engines: COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO, CINAHL, EBSCO and SCOPUS. The synthetic analytical method was used. Results: 40 bibliographic sources were found, of which 33 scientific articles were used that provided relevant information on the subject and seven articles were excluded. Discussion: There is scientific evidence about various bioactive compounds that experience efficacy in disease prevention through epigenetic regulation. Conclusion: With the continuous progress of changes in lifestyle, it is necessary to study new molecules, which can potentially be used for disease prevention and find new drugs that can be crucial in the treatment of different diseases.

Keywords: bioactive, food, regulators, epigenetics.

RESUMEN

Introducción: La nutrigenómica explora y define el campo en rápida evolución de las interacciones en la dieta y el genoma, mediante el uso de la nutrición, proteómica, fisiología, bioquímica y epigenómica para buscar y explicar las mutuas interacciones existentes entre genes y nutrientes desde un enfoque molecular. Objetivo: Resumir la evidencia del impacto que ejercen los compuestos bioactivos de los alimentos sobre los eventos epigenéticos dirigido principalmente en la prevención de enfermedades. Métodos: Se realizó una revisión bibliográfica acerca de los principales compuestos bioactivos de los alimentos como reguladores epigenéticos, en los siguientes buscadores: COCHRANE, PUBMED, MEDLINE, LILACS, SCIELO, CINAHL, EBSCO y SCOPUS. Se empleó el método analítico sintético. Resultados: Se encontraron 40 fuentes bibliográficas, de los cuales se utilizaron 33 artículos científicos que aportaron información relevante del tema y se excluyeron siete artículos. Discusión: Existe evidencia científica acerca de diversos compuestos bioactivos que demuestran eficacia en la prevención de enfermedades mediante la regulación epigenética. Conclusiones: Con el avance continuo de los cambios en el estilo de vida, es necesario estudiar nuevas moléculas, que pueden usarse potencialmente para la prevención de enfermedades y encontrar nuevos medicamentos que pueden ser cruciales en el tratamiento de distintas enfermedades.

Palabras clave: bioactivos, alimentos, reguladores, epigenética.

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