Dubai Medical Journal

Published date: Jun 30 2025

Journal Title: Dubai Medical Journal

Issue title: Dubai Medical Journal (DMJ): Volume 8, Issue 2

Pages: 230 - 249

DOI: 10.18502/dmj.v8i2.19010

Rasha MaryamCollege of Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Zyna FayazCollege of Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Nafila MusthafaCollege of Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Jasna Abdul JaleelCollege of Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Shadha Nasser Mohammed Bahutairshadhabahutair@gmail.comDepartment of Obstetrics and Gynecology, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Rasha Aziz Attia SalamaDepartment of Community Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Mohamed Anas PatniDepartment of Community Medicine, Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah

Introduction: Gestational diabetes (GDM) complicates around 14% of pregnancies globally. While GDM’s physiological effects are often transient, its long-lasting effects on the mother and the child are significant. Studies show a heightened chance of autism occurring in offspring subjected to gestational diabetes in utero.

Methods: A thorough search of literature was performed across PubMed, SCOPUS, and ProQuest, identifying 35 relevant studies published between 2012 and 2024. This review focuses on exploring the impact of GDM on the offspring’s chances of developing autism. It aims to explore the factors influencing this relationship, such as the timing of GDM onset, the presence of coexisting complications, and the condition’s underlying mechanisms.

Results: The findings demonstrate that gestational diabetes can significantly increase the risk of autism. Key factors influencing this relationship include the timing of diagnosis, maternal glucose management, and treatment strategies during pregnancy. Potential mechanisms include increased fetal exposure to inflammation, oxidative stress, and immune dysregulation.

Conclusion: The findings highlight the importance of early and effective GDM management and its pediatric implications for improving neurodevelopmental outcomes in offspring during early childhood.

Keywords: autistic spectrum disorder (ASD), endocrinology, gestational diabetes (GDM), neurodevelopmental disorders (NDD), psychiatry

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