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Introduction: It has been suggested that patients with autoimmune diseases are more likely to develop other malignancies. However, the association between lupus and multiple myeloma (MM) is still not much described in the literature.
Case Report: We report the observation of a 46-year-old female patient, in premenopause, in whom the diagnosis of systemic lupus was retained (SLICC criteria 7) with cutaneous, joint, hematological, immunological, and renal involvement. The discovery of MM was suspected due to a peak in gamma globulins on plasma protein electrophoresis and confirmed by myelogram. The outcome was fatal due to septic shock before starting any immunosuppression.
Discussion and Conclusion: In this literature review, 15 cases are reported on the occurrence of MM years after the diagnosis of lupus, only two cases were like our observation with a concomitant diagnosis of the 2 diseases. The management is still not codified; hence the prognosis of this association remains reserved, encouraging early detection of malignant plasma cell proliferation.
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[6] Lian L, Wang K, Xu S. Systemic lupus erythematosus associated with multiple myeloma: Two case reports and a literature review. Immun Inflamm Dis. 2023 Jan;11(1):e755. 

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[8] Bouatay A, Hizem, S, Youssef Y, Sayari F, Jmili N, Abderrahim K, Kortas M. Myélome multiple : Aspect clinique, diagnostic biologique et pronostic. Immuno-analyse & Biologie Spécialisée. 2013;28:30–35. 

[9] Desai R, Devaragudi S, Kaur L, Singh K, Bawa J, Theik NW, et al. SLE and multiple myeloma: An underlooked link? A review of case reports from the last decade. J Med Life. 2024 Feb;17(2):141–146."
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Concomitant Discovery of Systemic Lupus and Multiple Myeloma: Is It a Coincidence?

Published date: Dec 27 2024

Journal Title: Dubai Medical Journal

Issue title: Dubai Medical Journal (DMJ): Volume 7, Issue 4

Pages: 340 - 344

DOI: 10.18502/dmj.v7i4.17807

Authors:

Sara Anibars.anibar@uiz.ac.maNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir

Ihsene CherradiNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir

Mohammed BouchoualNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir

Marouane JabraneNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir

Mohamed ArrayhaniNephrology Department, Souss Massa University Hospital, Faculty of Medicine, Ibn Zohr University, Agadir

Abstract:

Introduction: It has been suggested that patients with autoimmune diseases are more likely to develop other malignancies. However, the association between lupus and multiple myeloma (MM) is still not much described in the literature.

Case Report: We report the observation of a 46-year-old female patient, in premenopause, in whom the diagnosis of systemic lupus was retained (SLICC criteria 7) with cutaneous, joint, hematological, immunological, and renal involvement. The discovery of MM was suspected due to a peak in gamma globulins on plasma protein electrophoresis and confirmed by myelogram. The outcome was fatal due to septic shock before starting any immunosuppression.

Discussion and Conclusion: In this literature review, 15 cases are reported on the occurrence of MM years after the diagnosis of lupus, only two cases were like our observation with a concomitant diagnosis of the 2 diseases. The management is still not codified; hence the prognosis of this association remains reserved, encouraging early detection of malignant plasma cell proliferation.

Keywords: multiple myeloma, systemic lupus, concomitant, diagnostic

References:

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