Dubai Medical Journal

ISSN: 2571-726X

Pioneering research in medicine, health sciences, nursing, pharmaceuticals, and laboratory work

Exploring the Connection Between Family History of Seizures and Post-traumatic Brain Injury Seizure Types: A Retrospective Study

Published date:Oct 30 2024

Journal Title: Dubai Medical Journal

Issue title: Dubai Medical Journal (DMJ): Volume 7, Issue 1

Pages:16 - 23

DOI: 10.18502/dmj.v7i1.17496

Authors:

Suleiman Daoudssdaoud@just.edu.joDepartment of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid

Rasha S. MustafaMD Intern, Ministry of Health, Irbid

Almutazballlah QablanMD Intern, Ministry of Health, Irbid

Yasmeen Jamal AlabdallatFaculty of Medicine, Hashemite University, Zarqa

Atef F. HullielFaculty of Medicine, Jordan University of Science and Technology, Irbid

Omar AhmadFaculty of Medicine, Jordan University of Science and Technology, Irbid

Adam M. AbdallahKing Abdullah University Hospital, Jordan University of Science and Technology, Irbid

Mohammad AlsharmanKing Abdullah University Hospital, Jordan University of Science and Technology, Irbid

Amer JaradatDepartment of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid

Sultan JarrarDepartment of Neurosurgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid

Mohammad A JamousKing Abdullah University Hospital, Jordan University of Science and Technology, Irbid

Mohemmed M. Al BarbarawiKing Abdullah University Hospital, Jordan University of Science and Technology, Irbid

Abstract:

Background: Traumatic brain injury (TBI) is one of the most common presentations to emergency departments and is associated with seizures carrying different significance at different stages following injury. The occurrence of seizures after head injury is a recognized complication of TBI and has been demonstrated to worsen functional outcomes significantly. Despite previous studies identifying various PTS risk factors, our understanding remains limited, particularly regarding familial seizure history.

Materials and Methods: A retrospective study was conducted at King Abdullah University Hospital (KAUH), Jordan, examining 1934 TBI cases from 2017 to 2023, identifying 118 patients with confirmed post-traumatic seizures.

Results: This study involved 118 TBI patients, aged between 2 and 86 years (median 21.5 years), with 74.6% male and 25.4% female. A family history of seizures was reported by 23.7% of patients. Intracerebral hemorrhage (ICH) (52.5%) and subarachnoid hemorrhage (SAH) (38.1%) were the predominant trauma types. Generalized tonicclonic (GTCs) seizures (69.5%) and focal seizures (30.5%) were observed post-TBI. Among 28 patients with a family history of seizures, no evidence of association was observed between the family history and post-traumatic seizure types (GTCs or focal seizures), this was confirmed by performing Chi-square tests (p = 0.9841) and logistic regression analysis (p = 0.79).

Conclusion: Our findings suggest that there is no evidence of the association between family history and post-traumatic seizure types, implying that a specialized approach for patients with positive family histories may not be warranted. Larger studies are recommended for further validation.

Keywords: TBI, PTS, seizure, epilepsy, family history

References:

[1] Fordington S, Manford M. A review of seizures and epilepsy following traumatic brain injury. J Neurol. 2020 Oct;267(10):3105–3111.

[2] Asikainen I, Kaste M, Sarna S. Early and late posttraumatic seizures in traumatic brain injury rehabilitation patients: Brain injury factors causing late seizures and influence of seizures on longterm outcome. Epilepsia. 1999 May;40(5):584–589.

[3] Anwer F, Oliveri F, Kakargias F, Panday P, Arcia Franchini AP, Iskander B, et al. Post-traumatic seizures: A deep-dive into pathogenesis. Cureus. 2021 Apr;13(4):e14395.

[4] DeGrauw X, Thurman D, Xu L, Kancherla V, DeGrauw T. Epidemiology of traumatic brain injuryassociated epilepsy and early use of anti-epilepsy drugs: An analysis of insurance claims data, 2004- 2014. Epilepsy Res. 2018 Oct;146:41–49.

[5] Frey LC. Epidemiology of posttraumatic epilepsy: A critical review. Epilepsia. 2003;44 s10:11–17.

[6] Annegers JF, Grabow JD, Groover RV, Laws ER Jr, Elveback LR, Kurland LT. Seizures after head trauma: A population study. Neurology. 1980 Jul;30(7 Pt 1):683–689.

[7] Salazar AM, Jabbari B, Vance SC, Grafman J, Amin D, Dillon JD. Epilepsy after penetrating head injury. I. Clinical correlates: A report of the Vietnam Head Injury Study. Neurology. 1985 Oct;35(10):1406–1414.

[8] Steinlein OK. Genetics and epilepsy. Dialogues Clin Neurosci. 2008;10(1):29–38.

[9] Guerrini R, Casari G, Marini C. The genetic and molecular basis of epilepsy. Trends Mol Med. 2003 Jul;9(7):300–306.

[10] Lamar CD, Hurley RA, Rowland JA, Taber KH. Post-traumatic epilepsy: Review of risks, pathophysiology, and potential biomarkers. J Neuropsychiatry Clin Neurosci. 2014 Apr;26(2):iv-113.

[11] Kodankandath TV, Theodore D, Samanta D. Generalized tonic-clonic seizure, in StatPearls. 2024: Treasure Island (FL) ineligible companies. Disclosure: Danny Theodore declares no relevant financial relationships with ineligible companies. Disclosure: Debopam Samanta declares no relevant financial relationships with ineligible companies.

[12] da Silva AM, Nunes B, Vaz AR, Mendonça D. Posttraumatic epilepsy in civilians: Clinical and electroencephalographic studies. Acta Neurochir Suppl (Wien). 1992;55:56–63.

[13] Tunthanathip T. Chapter 8: Seizures in traumatic brain injury: A focus on cellular aspects. In: Rajendram R, Preedy VR, Martin CR, editors. Cellular, molecular, physiological, and behavioral aspects of traumatic brain injury. Academic Press; 2022. pp. 95–105.

[14] Zhao Y, Wu H, Wang X, Li J, Zhang S. Clinical epidemiology of posttraumatic epilepsy in a group of Chinese patients. Seizure. 2012 Jun;21(5):322–326.

[15] Bögli SY, Wang S, Romaguera N, Schütz V, Rafi O, Gilone M, et al. Impact of seizures and status epilepticus on outcome in patients with aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2022 Jun;36(3):751–759.

[16] Labak CM, Shammassian BH, Zhou X, Alkhachroum A. Multimodality monitoring for delayed cerebral ischemia in subarachnoid hemorrhage: A mini review. Front Neurol. 2022 Apr;13:869107.

[17] Rhoney DH, Tipps LB, Murry KR, Basham MC, Michael DB, Coplin WM. Anticonvulsant prophylaxis and timing of seizures after aneurysmal subarachnoid hemorrhage. Neurology. 2000 Jul;55(2):258–265.

[18] Sundaram MB, Chow F. Seizures associated with spontaneous subarachnoid hemorrhage. Can J Neurol Sci. 1986 Aug;13(3):229–231.

[19] Gottesman RF, Komotar R, Hillis AE. Neurologic aspects of traumatic brain injury. Int Rev Psychiatry. 2003 Nov;15(4):302–309.

[20] Greene KA, Jacobowitz R, Marciano FF, Johnson BA, Spetzler RF, Harrington TR. Impact of traumatic subarachnoid hemorrhage on outcome in nonpenetrating head injury. Part II: Relationship to clinical course and outcome variables during acute hospitalization. J Trauma. 1996 Dec;41(6):964–971.

Cited by
?
EFFECT OF A PSYCHOEDUCATION PROGRAM BASED ON COGNITIVE-BEHAVIORAL PSYCHODRAMA TECHNIQUES ON PREMENSTRUAL SYNDROME SYMPTOMS: A RANDOMIZED CONTROLLED TRIAL.
Nihan Altan Sarikaya et al., PSYCHOLOGY, HEALTH & MEDICINE, 2024
THE RELATIONSHIP BETWEEN PREMENSTRUAL SYNDROME AND DIETARY HABITS AND NUTRIENTS INTAKE: DESCRIPTIVE AND ANALYTICAL CROSS- SECTIONAL STUDY
N. Erbil et al., CLINICAL AND EXPERIMENTAL HEALTH SCIENCES, 2024
RELATION BETWEEN METABOLIC SYNDROME AND PSYCHIATRIC SYMPTOMS SEVERITY IN WOMEN WITH PREMENSTRUAL SYNDROME
Mohamed Basiouny Yahia et al., THE EGYPTIAN JOURNAL OF NEUROLOGY, PSYCHIATRY AND NEUROSURGERY, 2024
PREMENSTRUAL SYNDROME SYMPTOMS IN WOMEN OF REPRODUCTIVE AGE – A PRELIMINARY REPORT
Agnieszka Bałanda-Bałdyga et al., KWARTALNIK NAUKOWY FIDES ET RATIO, 2023
CARACTERÍSTICAS E DIFERENÇAS NOS SINTOMAS DOS PERÍODOS MENSTRUAL E PRÉ-MENSTRUAL EM MULHERES SEDENTÁRIAS
Laura Zago et al., SEMINA: CIÊNCIAS BIOLÓGICAS E DA SAÚDE, 2023
Recommendations
CORRIGENDUM TO “COMPARISON OF CONVENTIONAL IVF VERSUS ICSI IN NON-MALE FACTOR, NORMORESPONDER PATIENTS” [IRAN J REPROD MED 2012; 10: 131-136]
M. Eftekhar et al., INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IJRM), 2021
CHRONIC STRESS INCREASES THE TYROSINE PHOSPHORYLATION IN FEMALE REPRODUCTIVE ORGANS: AN EXPERIMENTAL STUDY
S. Bunsueb et al., INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IJRM), 2021
DUAL STIMULATION IN UNEXPECTED POOR RESPONDER POSEIDON CLASSIFICATION GROUP 1, SUB–GROUP 2A: A CROSS-SECTIONAL STUDY
M. Eftekhar et al., INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IJRM), 2020
INCREASED EXPRESSION OF STEMNESS GENES REX-1, OCT-4, NANOG, AND SOX-2 IN WOMEN WITH OVARIAN ENDOMETRIOSIS VERSUS NORMAL ENDOMETRIUM: A CASE-CONTROL STUDY
F. Shariati et al., INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IJRM), 2018
CORRIGENDUM TO “DETERMINING THE SEXUAL QUALITY OF LIFE AND RELATED FACTORS IN PATIENTS REFERRED TO THE DEPARTMENT OF CARDIAC REHABILITATION: A CROSS-SECTIONAL STUDY” [INT J REPROD BIOMED 2021; 19: 261-270]
Iman Taqizade Firoozjaei et al., INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IJRM), 2021
Powered by
Download
HTML
Cite
Share
statistics

0 Abstract Views

42 PDF Downloads