Advances in Applied Nano-Bio Technologies

Published date: Oct 27 2025

Journal Title: Advances in Applied Nano-Bio Technologies

Issue title: Advances in Applied Nano-Bio Technologies: Volume 6 Issue 3

Pages: 23 - 34

DOI: 10.18502/aanbt.v6i3.18619

Ehsan KhaksarCyprus Health and Social Sciences University, Guzelyurt

Razieh AmiriDepartment of Endodontics, Dental school, Tehran University of Medical Sciences, Tehran

Fatemeh ZareiDental School, Shiraz University of Medical Sciences, Shiraz

Melika RezaeiFaculty of Materials Engineering, Islamic Azad University, Najafabad, Isfahan

Milad SaeedzadehDental School, Shiraz University of Medical Sciences, Shiraz

Yasamin GhahramaniGhahramani.yas@gmail.comOral and Dental Disease Research Center, Department of Endodontics, School of Dentistry, Shiraz University of Medical Sciences, Shiraz

Oral cancer, a leading cause of global mortality, is often diagnosed at advanced stages due to the limitations of conventional diagnostic methods, resulting in poor survival rates. Nanobiotechnology has emerged as a transformative approach to address this challenge by enabling highly sensitive, minimally invasive, and rapid detection of cancer-associated biomarkers in early malignancies. Utilizing engineered nanostructures such as quantum dots, nanosensors, and functionalized particles, this technology allows precise identification of biomarkers CD44 (Cluster of Differentiation 44), IL6 (Interleukin-6), ctDNA (Circulating Tumor DNA) in saliva or blood at extremely low concentrations. Innovations, including portable pointof- care (POC) devices, nanomaterial-enhanced imaging, and lab-on-a-chip systems, streamline screening, offering real-time results while reducing dependence on invasive biopsies. Despite its promise, challenges such as material biocompatibility, regulatory approval, and scalability in low-resource settings remain significant. Future directions emphasize the integration of artificial intelligence (AI) for predictive diagnostics, the development of multiplexed biomarker panels for greater accuracy, and the creation of theranostic platforms that combine detection with targeted therapy. By uniting accuracy, speed, and accessibility, nanobiotechnology has the potential to transform oral cancer management, shifting care from late-stage treatment toward proactive early intervention, ultimately improving patient outcomes worldwide.

Keywords: nanobiotechnology, oral cancer detection, nanoparticle probes, nanosensors, biomarkers

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