Advances in Applied Nano-Bio Technologies

ISSN: 2710-4001

The latest research in nano-biotechnology

New Approach in Nano Bio-active Materials in Cancer Therapy and Diagnosis Application

Published date:Dec 20 2024

Journal Title: Advances in Applied Nano-Bio Technologies

Issue title: Advances in Applied Nano-Bio Technologies: Volume 5 Issue 4

Pages:47 - 63

DOI: 10.18502/aanbt.v5i4.17962

Authors:

Raisa A. Aringazinaraisa_aringazina@mail.ruDepartment of Internal Diseases No. 1, West Kazakhstan Marat Ospanov Medical University, Aktobe

Afsaneh HoseinzadehBiotechnology Research Center, Shiraz University of Medical Sciences, Shiraz

Abstract:

The emergence of nanotechnology has revolutionized the field of cancer therapy and diagnosis, offering new avenues for more efficient and targeted treatments. A novel approach in the development of nano-bioactive materials has shown promise in improving the precision and effectiveness of both cancer therapies and diagnostic techniques. These materials, which can range from nanoparticles to nanostructured biomaterials, possess unique properties such as enhanced surface area, tunable sizes, and the ability to interact with biological systems at a molecular level. In cancer therapy, nano-bioactive materials can be engineered to deliver drugs directly to cancerous cells, reducing systemic toxicity and minimizing side effects associated with conventional treatments. This targeted drug delivery is facilitated by the specific interactions between nanomaterials and the tumor microenvironment, allowing for controlled release of therapeutic agents. Additionally, the use of these materials in combination with imaging agents enables early detection and monitoring of tumor progression, enhancing diagnostic accuracy. The ability to functionalize nanoparticles with ligands that bind selectively to cancer cell markers further improves the specificity of diagnosis and therapy. Recent developments in the design of multifunctional nanobioactive materials are also paving the way for combined therapeutic strategies, such as chemotherapy, gene therapy, and immunotherapy, all in one platform. Furthermore, these advanced materials offer the potential for real-time monitoring of treatment efficacy, providing valuable insights into tumor behavior and treatment response. As research continues, nano-bioactive materials are poised to become a cornerstone in the next generation of cancer management, offering safer, more personalized, and highly effective solutions for both therapy and diagnosis.

Keywords: Nanomaterials, Bioactive Agents, Cancer Therapy

References:

[1] Vinardell, M.P. and M. Mitjans, Antitumor activities of metal oxide nanoparticles. Nanomaterials, 2015. 5(2): p. 1004-1021.

[2] Conde, J., G. Doria, and P. Baptista, Noble metal nanoparticles applications in cancer. Journal of drug delivery, 2012. 2012(1): p. 751075.

[3] Sutradhar, K.B. and M.L. Amin, Nanotechnology in cancer drug delivery and selective targeting. International scholarly research notices, 2014. 2014(1): p. 939378.

[4] Zhao, G. and B.L. Rodriguez, Molecular targeting of liposomal nanoparticles to tumor microenvironment. International journal of nanomedicine, 2012: p. 61-71.

[5] Nguyen, K.T., Targeted nanoparticles for cancer therapy: promises and challenges. J. Nanomed. Nanotechnol, 2011. 2(05).

[6] Coates, A., et al., On the receiving end—patient perception of the side-effects of cancer chemotherapy. European Journal of Cancer and Clinical Oncology, 1983. 19(2): p. 203-208.

[7] Sharma, A., A.K. Goyal, and G. Rath, Recent advances in metal nanoparticles in cancer therapy. Journal of drug targeting, 2018. 26(8): p. 617-632.

[8] Ho, B.N., C.M. Pfeffer, and A.T. Singh, Update on nanotechnology-based drug delivery systems in cancer treatment. Anticancer research, 2017. 37(11): p. 5975-5981.

[9] Harsha Kharkwal, H.K. and S.J. Srinivas Janaswamy, Natural polymers for drug delivery. 2017: CABI.

[10] Ficai, D. and A. Ficai, New Challenges in Cancer Treatment, from Novel Agents to Innovative Administration. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry- Anti-Cancer Agents), 2019. 19(1): p. 4-5.

[11] Sack, M., et al., Combination of conventional chemotherapeutics with redox-active cerium oxide nanoparticles—a novel aspect in cancer therapy. Molecular cancer therapeutics, 2014. 13(7): p. 1740- 1749.

[12] Kumar, A., et al., DFT study of [Pt (Cl) 2L] complex (L= rubeanic acid) and its derived compounds with DNA purine bases. Chemical Physics, 2020. 530: p. 110646.

[13] Kumari, M., et al., Toxicity study of cerium oxide nanoparticles in human neuroblastoma cells. International journal of toxicology, 2014. 33(2): p. 86-97.

[14] Sreena, R. and A.J. Nathanael, Biodegradable biopolymeric nanoparticles for biomedical applicationschallenges and future outlook. Materials, 2023. 16(6): p. 2364.

[15] Balogh, L.P., Nano-enabled medical applications. 2020: CRC Press.

[16] Dessale, M., G. Mengistu, and H.M. Mengist, Nanotechnology: a promising approach for cancer diagnosis, therapeutics and theragnosis. International Journal of Nanomedicine, 2022. 17: p. 3735.

[17] Machado, S., et al., Utilization of food industry wastes for the production of zero-valent iron nanoparticles. Science of the Total Environment, 2014. 496: p. 233-240.

[18] Yang, Q., et al., Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation. Molecular pharmaceutics, 2014. 11(4): p. 1250-1258.

[19] Zeineldin, R., Cancer nanotechnology: methods and protocols. 2017: Springer.

[20] Hashemi, S.A., et al., Ultra-precise label-free nanosensor based on integrated graphene with Au nanostars toward direct detection of IgG antibodies of SARS-CoV-2 in blood. Journal of Electroanalytical Chemistry, 2021. 894: p. 115341.

[21] Jani, P., et al., Theranostic nanocarriers in cancer: dual capabilities on a single platform. Functional Bionanomaterials: From Biomolecules to Nanoparticles, 2020: p. 293-312.

[22] Vogel, H.G., J. Maas, and A. Gebauer, Drug discovery and evaluation: methods in clinical pharmacology. 2010: Springer Science & Business Media.

[23] Saxena, S.K., et al., Current advances in nanotechnology and medicine. NanoBioMedicine, 2020: p. 3-16.

[24] Mukherjee, A. and S. Bhattacharyya, Nanotechnology in medicine. Biotechnology business-concept to delivery, 2020: p. 57-64.

[25] Mousavi, S.M., et al., Recent biotechnological approaches for treatment of novel COVID-19: from bench to clinical trial. Drug Metabolism Reviews, 2021. 53(1): p. 141-170.

[26] Pedrosa, P., et al., Gold nanotheranostics: proof-of-concept or clinical tool? Nanomaterials, 2015. 5(4): p. 1853-1879.

[27] De Jong, W.H. and P.J. Borm, Drug delivery and nanoparticles: applications and hazards. International journal of nanomedicine, 2008. 3(2): p. 133-149.

[28] Ernsting, M.J., et al., Factors controlling the pharmacokinetics, biodistribution and intratumoral penetration of nanoparticles. Journal of controlled release, 2013. 172(3): p. 782-794.

[29] Barar, J. and Y. Omidi, Dysregulated pH in tumor microenvironment checkmates cancer therapy. BioImpacts: BI, 2013. 3(4): p. 149.

[30] Omidi, Y. and J. Barar, Targeting tumor microenvironment: crossing tumor interstitial fluid by multifunctional nanomedicines. BioImpacts: BI, 2014. 4(2): p. 55.

[31] Li, Y., et al., Advances in the Study of Bioactive Nanoparticles for the Treatment of HCC and Its Postoperative Residual Cancer. International Journal of Nanomedicine, 2023: p. 2721-2735.

[32] Bilobrov, V., et al., A novel nanoconjugate of landomycin A with C 60 fullerene for cancer targeted therapy: in vitro studies. Cellular and Molecular Bioengineering, 2019. 12: p. 41-51.

[33] Pan, S., et al., Drug delivery systems for cardiovascular ailments, in Drug Delivery Devices and Therapeutic Systems. 2021, Elsevier. p. 567-599.

[34] Hasanzade, Z. and H. Raissi, Carbon and boron nanotubes as a template material for adsorption of 6-Thioguanine chemotherapeutic: a molecular dynamics and density functional approach. Journal of Biomolecular Structure and Dynamics, 2020.

[35] Klebowski, B., et al., Gold-decorated platinum and palladium nanoparticles as modern nanocomplexes to improve the effectiveness of simulated anticancer proton therapy. Pharmaceutics, 2021. 13(10): p. 1726.

[36] Wang, L., et al., Serum exosomal miR-377-3p and miR-381-3p as diagnostic biomarkers in colorectal cancer. Future Oncology, 2022. 18(7): p. 793-805.

[37] Karimi, S. and H. Namazi, Simple preparation of maltose-functionalized dendrimer/graphene quantum dots as a pH-sensitive biocompatible carrier for targeted delivery of doxorubicin. International journal of biological macromolecules, 2020. 156: p. 648-659.

[38] Jin, S.-E., H.-E. Jin, and S.-S. Hong, Targeted delivery system of nanobiomaterials in anticancer therapy: from cells to clinics. BioMed research international, 2014. 2014(1): p. 814208.

[39] Shamaeizadeh, A., et al., Smart Nanobiomaterials for Gene Delivery in Localized Cancer Therapy: An Overview from Emerging Materials and Devices to Clinical Applications. Current Cancer Drug Targets, 2024.

[40] Sampathkumar, K., S. Arulkumar, and M. Ramalingam, Advances in stimuli responsive nanobiomaterials for cancer therapy. Journal of biomedical nanotechnology, 2014. 10(3): p. 367-382.

[41] Monfared, M., et al., Emerging frontiers in drug release control by core–shell nanofibers: A review. Drug metabolism reviews, 2019. 51(4): p. 589-611.

[42] López, T., P. Larraza, and E. Gómez, Platinum and Copper Supported in Functionalized Titania Nanoparticles for the Treatment of Cervical and Prostate Cancer. J Nanomater Mol Nanotechnol 6: 4. of, 2017. 6: p. 2.

[43] Scott, E.A., N.B. Karabin, and P. Augsornworawat, Overcoming immune dysregulation with immunoengineered nanobiomaterials. Annual review of biomedical engineering, 2017. 19(1): p. 57- 84.

[44] Shadjou, N. and M. Hasanzadeh, Silica-based mesoporous nanobiomaterials as promoter of bone regeneration process. Journal of Biomedical Materials Research Part A, 2015. 103(11): p. 3703-3716.

[45] Kawassaki, R.K., et al., Titanium and iron oxide nanoparticles for cancer therapy: surface chemistry and biological implications. Frontiers in Nanotechnology, 2021. 3: p. 735434.

[46] Juneja, A. and A. Sultan, Nanotechnology and nanobiomaterials: redefining ways of managing oral cancer. Online Turkish Journal of Health Sciences, 2020. 5(4): p. 693-700.

[47] Mousavi, S.M., et al., Highly sensitive flexible SERS-based sensing platform for detection of COVID-19. Biosensors, 2022. 12(7): p. 466.

[48] Maria Rosa da Silva, F., et al., Nano-hydroxyapatite doped with Ho-166 as drug delivery system for bone cancer therapy and diagnosis: developing a theragnostic radiopharmaceuticals. Anti-Cancer Agents in Medicinal Chemistry-Anti-Cancer Agents), 2017. 17(3): p. 355-358.

[49] Li, R., et al., Radiotherapy for glioblastoma: clinical issues and nanotechnology strategies. Biomaterials Science, 2022. 10(4): p. 892-908.

[50] Zhou, Q., L. Zhang, and H. Wu, Nanomaterials for cancer therapies. Nanotechnology Reviews, 2017. 6(5): p. 473-496.

[51] Wang, X., et al., Evaluating diabetic ketoacidosis via a MOF sensor for fluorescence imaging of phosphate and pH. Chemical Communications, 2022. 58(18): p. 3023-3026.

[52] Zhang, W., et al., Evaluating hyperthyroidism-induced liver injury based on in situ fluorescence imaging of glutathione and phosphate via nano-MOFs sensor. Analytical Chemistry, 2020. 92(13): p. 8952- 8958.

[53] El Fawal, G., et al., Polyvinyl alcohol/hydroxyethylcellulose containing ethosomes as a scaffold for transdermal drug delivery applications. Applied Biochemistry and Biotechnology, 2020. 191: p. 1624- 1637.

[54] Li, B. and X. Yang, Rutin-loaded cellulose acetate/poly (ethylene oxide) fiber membrane fabricated by electrospinning: A bioactive material. Materials Science and Engineering: C, 2020. 109: p. 110601.

[55] Mousavi, S.M., et al., The pivotal role of quantum dots-based biomarkers integrated with ultra-sensitive probes for multiplex detection of human viral infections. Pharmaceuticals, 2022. 15(7): p. 880.

[56] Najlah, M., et al., Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer. European Journal of Pharmaceutics and Biopharmaceutics, 2017. 112: p. 224-233.

[57] Zhuang, Y., K. Lin, and H. Yu, Advance of nano-composite electrospun fibers in periodontal regeneration. Frontiers in Chemistry, 2019. 7: p. 495.

[58] Campiglio, C.E., C. Marcolin, and L. Draghi, Electrospun ECM macromolecules as biomimetic scaffold for regenerative medicine: Challenges for preserving conformation and bioactivity. AIMS Materials Science, 2017. 4(3): p. 638-669.

[59] Hashemi, S.A., et al., Bio-enhanced polyrhodanine/graphene Oxide/Fe3O4 nanocomposite with kombucha solvent supernatant as ultra-sensitive biosensor for detection of doxorubicin hydrochloride in biological fluids. Materials Chemistry and Physics, 2022. 279: p. 125743.

[60] Qasim, S.B., et al., Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration. Dental Materials, 2017. 33(1): p. 71-83.

[61] Eskitoros-Togay, Ş.M., et al., Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system. International journal of pharmaceutics, 2019. 565: p. 83-94.

[62] Kim, K., et al., Incorporation and controlled release of a hydrophilic antibiotic using poly (lactideco- glycolide)-based electrospun nanofibrous scaffolds. Journal of controlled release, 2004. 98(1): p. 47-56.

[63] Ulery, B.D., et al., Design of a protective single-dose intranasal nanoparticle-based vaccine platform for respiratory infectious diseases. PloS one, 2011. 6(3): p. e17642.

[64] Jiang, H., et al., Preparation and characterization of ibuprofen-loaded poly (lactide-co-glycolide)/poly (ethylene glycol)-g-chitosan electrospun membranes. Journal of Biomaterials Science, Polymer Edition, 2004. 15(3): p. 279-296.

[65] Gao, L., et al., An artificial metalloenzyme for catalytic cancer-specific DNA cleavage and operando imaging. Science Advances, 2020. 6(29): p. eabb1421.

[66] Hooshmand, S., et al., Mesoporous silica nanoparticles and mesoporous bioactive glasses for wound management: from skin regeneration to cancer therapy. Materials, 2021. 14(12): p. 3337.

[67] Spyridopoulou, K., Design and application of bioactive nanoparticles in cancer prevention and therapy. 2018.

[68] Mousavi, S.M., et al., Recent advances in inflammatory diagnosis with graphene quantum dots enhanced SERS detection. Biosensors, 2022. 12(7): p. 461.

[69] Lai, C., et al., Research Progress of Chitosan-based Multifunctional Nanoparticles in Cancer Targeted Therapy. Current Medicinal Chemistry, 2024. 31(21): p. 3074-3092.

[70] Goldberg, M.S., Immunoengineering: how nanotechnology can enhance cancer immunotherapy. Cell, 2015. 161(2): p. 201-204.

[71] Fan, Y. and J.J. Moon, Nanoparticle drug delivery systems designed to improve cancer vaccines and immunotherapy. Vaccines, 2015. 3(3): p. 662-685.

[72] Mousavi, S.M., et al., Biomedical applications of an ultra-sensitive surface plasmon resonance biosensor based on smart MXene quantum dots (SMQDs). Biosensors, 2022. 12(9): p. 743.

[73] Chithrani, B.D., A.A. Ghazani, and W.C. Chan, Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells. Nano letters, 2006. 6(4): p. 662-668.

[74] Agarwal, R., et al., Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms. Proceedings of the National Academy of Sciences, 2013. 110(43): p. 17247-17252.

[75] Toy, R. and K. Roy, Engineering nanoparticles to overcome barriers to immunotherapy. Bioengineering & translational medicine, 2016. 1(1): p. 47-62.

[76] Dourado, D., et al., Recent Trends in Curcumin-Containing Inorganic-Based Nanoparticles Intended for In Vivo Cancer Therapy. Pharmaceutics, 2024. 16(2): p. 177.

[77] Tinajero-Diaz, E., et al., Green metallic nanoparticles for cancer therapy: evaluation models and cancer applications. Pharmaceutics, 2021. 13(10): p. 1719.

[78] El-Sheekh, M.M., et al., How synthesis of algal nanoparticles affects cancer therapy?–A complete review of the literature. International Journal of Nanomedicine, 2023: p. 6601-6638.

[79] Zhu, L., et al., Inhibition of NADPH oxidase-ros signal using hyaluronic acid nanoparticles for overcoming radioresistance in cancer therapy. ACS nano, 2022. 16(11): p. 18708-18728.

[80] Ganesan, K., et al., Targeting engineered nanoparticles for breast cancer therapy. Pharmaceutics, 2021. 13(11): p. 1829.

[81] Dong, X., et al., Engineered living bacteriophage-enabled self-adjuvanting hydrogel for remodeling tumor microenvironment and cancer therapy. Nano Letters, 2023. 23(4): p. 1219-1228.

[82] Mobarak, M.B., et al., Calcined chicken eggshell-derived biomimetic nano-hydroxyapatite as a local drug-delivery aid for doxycycline hyclate: characterization, bio-activity, cytotoxicity, antibacterial activity and in vitro release study. RSC advances, 2023. 13(51): p. 36209-36222.

[83] Jonoush, Z.A., et al., Surface modification of graphene and its derivatives for drug delivery systems. Mini-Reviews in Organic Chemistry, 2021. 18(1): p. 78-92.

[84] Ruirui, Z., et al., PLGA-based drug delivery system for combined therapy of cancer: Research progress. Materials Research Express, 2021. 8(12): p. 122002.

[85] Duan, W., et al., Compartmentalized nano-MOFs as co-delivery systems for enhanced antitumor therapy. ACS Applied Materials & Interfaces, 2023. 15(33): p. 39039-39052.

[86] Zhang, K., et al., Potential for layered double hydroxides-based, innovative drug delivery systems. International journal of molecular sciences, 2014. 15(5): p. 7409-7428.

[87] Vichery, C. and J.-M. Nedelec, Bioactive glass nanoparticles: from synthesis to materials design for biomedical applications. Materials, 2016. 9(4): p. 288.

[88] Gupta, Y., et al., The Uniqueness of Albumin as a Carrier in Nano Drug Delivery. Journal for Research in Applied Sciences and Biotechnology, 2024. 3(1): p. 7-11.

[89] Mousavi, S.M., et al., Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection. Pharmaceutics, 2022. 14(5): p. 1054.

[90] Malavasi, G., et al., Novel smart bio-nanomaterials: bioactive glasses containing metal nano-particles conjugated with molecules of biological interest, in Nanotechnology 2012: Bio Sensors, Instruments, Medical, Environment and Energy: Bio Nano Materials. 2012, www. nsti. org. p. 114-117.

[91] Malik, A.A., et al., Applications of Organic Chemistry in Nano-Medicine: Current and Future Prospects, in Applications of Nanomaterials in Agriculture, Food Science, and Medicine. 2021, IGI Global. p. 116- 123.

[92] Golafzani, F.N., et al., Delivery of miRNA-126 through folic acid-targeted biocompatible polymeric nanoparticles for effective lung cancer therapy. Journal of Bioactive and Compatible Polymers, 2022. 37(3): p. 168-188.

[93] Ignjatović, N.L., et al., In vitro evaluation of a multifunctional nano drug delivery system based on tigecycline-loaded calcium-phosphate/poly-DL-lactide-co-glycolide. Bio-medical materials and engineering, 2014. 24(4): p. 1647-1658.

[94] Bhatia, S. and S. Bhatia, Nanoparticles types, classification, characterization, fabrication methods and drug delivery applications. Natural polymer drug delivery systems: Nanoparticles, plants, and algae, 2016: p. 33-93.

[95] Gonzalez, G., A. Sagarzazu, and T. Zoltan, Infuence of microstructure in drug release behavior of silica nanocapsules. Journal of drug delivery, 2013. 2013(1): p. 803585.

[96] Huang, Y., et al., Nano traditional Chinese medicine: current progresses and future challenges. Current Drug Targets, 2015. 16(13): p. 1548-1562.

[97] Veerapandian, M., et al., Drug delivery application of functional nanomaterials synthesized using natural sources. Journal of Functional Biomaterials, 2023. 14(8): p. 426.

Download
HTML
Cite
Share
statistics

0 Abstract Views

PDF Downloads