Sudan Journal of Medical Sciences

ISSN: 1858-5051

High-impact research on the latest developments in medicine and healthcare across MENA and Africa

Effect of Body Composition on Ventilation Parameters in a Group of Young Sudanese Females

Published date: Jul 04 2017

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 12 (2017), Issue No. 2

Pages: 78-88

DOI: 10.18502/sjms.v12i2.918

Authors:

N. A. AlaagibEmail: nouralsalhin@gamil.com
Affiliation:
Biography:

M.Y. SukkarEmail: N/A
Affiliation:
Biography:

N. A. Alaagib - nouralsalhin@gamil.com

M.Y. Sukkar

Abstract:

Background: Lung Function Test helps (LFT) in the diagnosis and follow up of patients with pulmonary or cardiac diseases. Ignoring BMI and body composition during interpretation of LFT results may lead to wrong diagnosis and unnecessary use of drugs.

Objective: This study was conducted to test the hypothesis that differences in body composition between individuals can explain some of the features of LFT that are explained by variations in age, sex, and height only.

Methods: This observational analytical cross sectional study which included 150 young adult females. Those with history of amenorrhea, smoking, asthma or cardiac disease were excluded. Anthropometric measurements including: BMI, waist circumference (WC) and body fat percent calculated from skinfold thickness measurements were done. Dynamic spirometric tests were performed using digital spirometer; FEV1, FVC, FEV1% were measured.

Results: Both obese and underweight subjects had a significant reduction in FEV1 (P=.002) and FVC (P=.004) compared to normal ones. FEV1% was significantly higher in the overweight and obese group compared to the other two groups (P=.02). Body weight, BMI, and WC had significant positive correlation with FEV1 and FEV1% in young healthy females.

Conclusion: Increase in BMI, body weight, WC and body fat showed positive significant correlation with FEV1% and may give a restrictive pattern in LFT. Underweight subjects may show significant reduction in lung function if their BMI is not considered.

References:

[1] D. J. Chinn, J. E. Cotes, and J. W. Reed, “Longitudinal effects of change in body mass on measurements of ventilatory capacity,” Thorax, vol. 51, no. 7, pp. 699–704, 1996.

[2] M. Golshan, M. Nematbakhsh, B. Amra, and R. O. Crapo, “Spirometric reference values in a large Middle Eastern population,” European Respiratory Journal, vol. 22, no. 3, pp. 529–534, 2003.

[3] C. M. Salome, G. G. King, and N. Berend, “Physiology of obesity and effects on lung function,” Journal of Applied Physiology, vol. 108, no. 1, pp. 206–211, 2010.

[4] A. M. Li, “The effects of obesity on pulmonary function,” Archives of Disease in Childhood, vol. 88, no. 4, pp. 361–363.

[5] H. Sahebjami and P. S. Gartside, “Pulmonary function in obese subjects with a normal FEV1/FVC ratio,” Chest, vol. 110, no. 6, pp. 1425–1429, 1996.

[6] D. D. Sin, R. L. Jones, and S. F. Paul Man, “Obesity is a risk factor for dyspnea but not for airflow obstruction,” Archives of Internal Medicine, vol. 162, no. 13, pp. 1477–1481, 2002.

[7] C. A. Camargo Jr., S. T. Weiss, S. Zhang, W. C. Willett, and F. E. Speizer, “Prospective study of body mass index, weight change, and risk of adult-onset asthma in women,” Archives of Internal Medicine, vol. 159, no. 21, pp. 2582–2588, 1999.

[8] S. Chinn, D. Jarvis, and P. Burney, “Relation of bronchial responsiveness to body mass index in the ECRHS,” Thorax, vol. 57, no. 12, pp. 1028–1033, 2002.

[9] L. M. Schachter, C. M. Salome, J. K. Peat, and A. J. Woolcock, “Obesity is a risk for asthma and wheeze but not airway hyperresponsiveness,” Thorax, vol. 56, no. 1,pp. 4–8, 2001.

[10] R. L. Jones and M.-M. U. Nzekwu, “The effects of body mass index on lung volumes,” Chest, vol. 130, no. 3, pp. 827–833, 2006.

[11] M. Bottai, F. Pistelli, F. Di Pede et al., “Longitudinal changes of body mass index, spirometry and diffusion in a general population,” European Respiratory Journal,vol. 20, no. 3, pp. 665–673, 2002.

[12] K. M. McClean, F. Kee, I. S. Young, and J. S. Elborn, “Obesity and the lung: 1 · Epidemiology,” Thorax, vol. 63, no. 7, pp. 649–654, 2008.

[13] K. M. McClean, C. R. Cardwell, and F. Kee, “Longitudinal change in BMI and lung function in middle-aged men in Northern Ireland,” Ir J Med Sci, vol. 176, p. S418,2007.

[14] J. E. Cotes, D. J. Chinn, and J. W. Reed, “Body mass, fat percentage, and fat free mass as reference variables for lung function: effects on terms for age and sex,” Thorax, vol. 56, no. 11, pp. 839–844, 2001.

[15] Y. Chen, D. Rennie, Y. Cormier, and J. A. Dosman, “Waist circumference is associatedwith pulmonary function in normal-weight, overweight, and obese subjects,” Am J ClinNutr, vol. 85, pp. 35–39, 2007.

[16] L. C. Collins, P. D. Hoberty, J. F. Walker, E. C. Fletcher, and A. N. Peiris, “The effect of body fat distribution on pulmonary function tests,” Chest, vol. 107, no. 5, pp.1298–1302, 1995.

[17] R. Lazarus, D. Sparrow, and S. T. Weiss, “Effects of obesity and fat distribution on ventilatory function: The normative aging study,” Chest, vol. 111, no. 4, pp. 891–898,1997.

[18] H. M. Ochs-Balcom, B. J. B. Grant, P. Muti et al., “Pulmonary function and abdominal adiposity in the general population,” Chest, vol. 129, no. 4, pp. 853–862, 2006.

[19] J. V. Durnin and J. Womersley, “Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years,” British Journal of Nutrition, vol. 32, no. 1, pp. 77–97, 1974.

[20] J. Parízková and P. Bůzková, “Relationship between skinfold thickness measured by Harpenden caliper and densitometric analysis of total body fat in men.,” Human Biology, vol. 43, no. 1, pp. 16–21, 1971.

[21] American Thoracic Society, “Standardization of spirometry, 1994 update,” American Journal of Respiratory and Critical Care Medicine, vol. 152, no. 3, pp. 1107–1136, 1995.

[22] World Health Organization, Obesity and Overweight. World Health Organization Global strategy on Diet, Physical activity and Health, 2003.

Download
HTML
Cite
Share
statistics

829 Abstract Views

169 PDF Downloads