Sudan Journal of Medical Sciences

ISSN: 1858-5051

High-impact research on the latest developments in medicine and healthcare across MENA and Africa

COVID-19: How Effective Are the Repurposed Drugs and Novel Agents in Treating the Infection?

Published date: Dec 31 2022

Journal Title: Sudan Journal of Medical Sciences

Issue title: Sudan JMS: Volume 17 (2022), Issue No. 4

Pages: 498–538

DOI: 10.18502/sjms.v17i4.12550

Authors:

Chow Suet-MayEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Kuok Sin-YeeEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Lee Jia-QingEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Goh Pey-WenEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Harleen Kaur A/P Ranjit SinghEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Timothy Tan Zhi-ZhengEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Jhi-Biau FooEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Sharina HamzahEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Renukha SellappansEmail: N/A
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Yow Hui-YinEmail: huiyin.yow@um.edu.my
Affiliation: School of Pharmacy, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia
Biography:

Chow Suet-May - https://orcid.org/0000-0001-8918-2135

Kuok Sin-Yee

Lee Jia-Qing

Goh Pey-Wen

Harleen Kaur A/P Ranjit Singh

Timothy Tan Zhi-Zheng

Jhi-Biau Foo - https://orcid.org/0000-0002-5880-2220

Sharina Hamzah - https://orcid.org/0000-0001-6268-9059

Renukha Sellappans - https://orcid.org/0000-0002-9338-735X

Yow Hui-Yin - huiyin.yow@um.edu.my - https://orcid.org/0000-0002-9455-0817

Abstract:

Coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) has impacted the lives and wellbeing of many people. This globally widespread disease poses a significant public health concern that urges to discover an effective treatment. This review paper discusses the effectiveness of repurposed drugs used to treat COVID-19 and potential novel therapies for COVID-19. Among the various repurposed drugs, remdesivir is the only agent approved by the Food and Drug Administration (FDA) to treat COVID-19. On the other hand, several drugs have been listed in the Emergency Use Authorization (EUA) by the FDA to treat COVID-19, including casirivimab and imdevimab, baricitinib (in combination with remdesivir), bamlanivimab, tocilizumab, and IL-6 inhibitors. In addition, in vitro and clinical studies have suggested cepharanthine, sotrovimab, and XAV-19 as potential treatments to manage COVID-19. Due to inadequate understanding of COVID-19 and the rapid mutation of SARS-CoV-2, COVID-19 remains a threat to global public health, with vaccination considered the most effective method to decrease COVID-19 transmission currently. Nevertheless, with the intense efforts of clinical researchers globally, more promising treatments for COVID-19 will be established in the future.

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