Sudan Journal of Medical Sciences
ISSN: 1858-5051
High-impact research on the latest developments in medicine and healthcare across MENA and Africa
Comparing General versus Spinal Anesthesia for Cesarean Section in a Severely Pre-eclamptic Parturients
Published date: Dec 31 2024
Journal Title: Sudan Journal of Medical Sciences
Issue title: Sudan JMS: Volume 19 (2024), Issue No. 4
Pages: 473 – 481
Authors:
Abstract:
Background: Preeclampsia poses a high challenge during anesthesia. Both spinal anesthesia (SA) and general anesthesia (GA) are commonly used for the operative management of severe preeclampsia. The study aimed to assess feto-maternal outcomes among severely preeclamptic parturients scheduled for emergency cesarean section (C/S) delivery under GA or SA.
Methods: A total of 80 parturients were enrolled into two equal groups, one group received SA and the other GA. Vital parameters were recorded before starting and during the procedure. The Chi-square test was used for analysis. A P-value of ≤0.05 was considered significant.
Results: Both groups were similar in age, weight, parity, gestational age, and duration of surgery. An intraoperative need for vasopressors was higher in anesthesia (P-value 0.013). Significant intraoperative decreases in blood pressure were observed in SA. The rate of intensive care unit (ICU) admission was higher in GA (11 vs 4 patients, P-value 0.0463).
Conclusion: Assuming no contraindication, SA is the first choice for cesarean section delivery in a severely preeclamptic parturient.
Keywords: anesthesia, cesarean section, pregnancy hypertensive disorders, severe preeclampsia
References:
[1] Mustafa, R., Ahmed, S., Gupta, A., & Venuto, R. C. (2012). A comprehensive review of hypertension in pregnancy. Journal of Pregnancy, 2012, 105918. https://doi.org/10.1155/2012/105918
[2] von Dadelszen, P., & Magee, L. A. (2016). Preventing deaths due to the hypertensive disorders of pregnancy. Best Practice & Research. Clinical Obstetrics & Gynaecology, 36, 83–102. https://doi.org/10.1016/j.bpobgyn.2016.05.005
[3] Vest, A. R., & Cho, L. S. (2012). Hypertension in pregnancy. Cardiology Clinics, 30(3), 407–423. https://doi.org/10.1016/j.ccl.2012.04.005
[4] Gupte, S., & Wagh, G. (2014). Preeclampsiaeclampsia. Journal of Obstetrics and Gynecology of India, 64(1), 4–13. https://doi.org/10.1007/s13224-014- 0502-y
[5] Dhillion, P., Wallace, K., Herse, F., Scott, J., Wallukat, G., Heath, J., Mosely, J., Martin, J. N., Jr., Dechend, R., & LaMarca, B. (2012). IL-17-mediated oxidative stress is an important stimulator of AT1- AA and hypertension during pregnancy. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 303(4), R353–R358. https://doi.org/10.1152/ajpregu.00051.2012
[6] Amaral, L. M., Wallace, K., Owens, M., & LaMarca, B. (2017). Pathophysiology and current clinical management of preeclampsia. Current Hypertension Reports, 19(8), 61. https://doi.org/10.1007/s11906-017- 0757-7
[7] Perni, U., Sison, C., Sharma, V., Helseth, G., Hawfield, A., Suthanthiran, M., & August, P. (2012). Angiogenic factors in superimposed preeclampsia: A longitudinal study of women with chronic hypertension during pregnancy. Hypertension, 59(3), 740–746. https: //doi.org/10.1161/HYPERTENSIONAHA.111.181735
[8] Barton, J. R., Saade, G. R., & Sibai, B. M. (2020). A proposed plan for prenatal care to minimize risks of COVID-19 to patients and providers: Focus on hypertensive disorders of pregnancy. American Journal of Perinatology, 37(8), 837–844. https://doi.org/10.1055/s-0040-1710538
[9] Ajuzieogu, O. V., Ezike, H. A., Amucheazi, A. O., & Enwereji, J. (2011). A retrospective study of the outcome of cesarean section for women with severe pre-eclampsia in a third world setting. Saudi Journal of Anaesthesia, 5(1), 15–18. https://doi.org/10.4103/1658-354X.76480
[10] Chattopadhyay, S., Das, A., & Pahari, S. (2014). Fetomaternal outcome in severe preeclamptic women undergoing emergency cesarean section under either general or spinal anesthesia. Journal of Pregnancy, 2014, 325098. https://doi.org/10.1155/2014/325098
[11] Adugna, A., Tsehay, T., Wossenyeleh, A., & Leulayehu, A. (2018). Comparing the effect of spinal and general anaesthesia for pre-eclamptic mothers who underwent caesarean delivery in Black Lion Specialized Hospital, Addis Ababa, Ethiopia. Ethiopian Journal of Health Sciences, 28(4), 443.
[12] Dyer, R. A., Els, I., Farbas, J., Torr, G. J., Schoeman, L. K., & James, M. F. (2003). Prospective, randomized trial comparing general with spinal anesthesia for cesarean delivery in preeclamptic patients withnonreassuring fetal heart trace. Anesthesiology, 99(3), 561–569. https://doi.org/10.1097/00000542- 200309000-00010
[13] Obi, V. O. J., & Umeora, O. U. (2018). Anesthesia for emergency cesarean section: A comparison of spinal versus general anesthesia on maternal and neonatal outcomes. African Journal of Medical and Health Sciences, 17, 31–34. https://doi.org/10.4103/ajmhs.ajmhs_33_18
[14] Ravi, T., Kumar, N. D., & Raju, K. (2016). Analysis of maternal outcome of general versus spinal anesthesia for caesarean delivery in severe pre-eclampsia. Asian Pacific Journal of Health Sciences, 3(3), 101– 107. https://doi.org/10.21276/apjhs.2016.3.3.17
[15] Keerath, K., & Cronje, L. (2012). Observational study of choice of anaesthesia and outcome in patients with severe pre-eclampsia who present for emergency Caesarean section. The South African Journal of Anaesthesiology and Analgesia, 18(4), 206–212. https://doi.org/10.1080/22201173.2012.10872854
[16] Sivevski, A., Ivanov, E., Karadjova, D., Slaninka- Miceska, M., & Kikerkov, I. (2019). Spinal-induced hypotension in preeclamptic and healthy parturients undergoing cesarean section. Open Access Macedonian Journal of Medical Sciences, 7(6), 996–1000. https://doi.org/10.3889/oamjms.2019.230
[17] Edipoglu, I. S., Celik, F., Marangoz, E. C., & Orcan, G. H. (2018). Effect of anaesthetic technique on neonatal morbidity in emergency caesarean section for foetal distress. PLoS One, 13(11), e0207388. https://doi.org/10.1371/journal.pone.0207388
[18] Okafor UV, Okezie O. (2005). Maternal and fetal outcome of anaesthesia for caesarean delivery in pre-eclampsia/eclampsia in Enugu, Nigeria: A retrospective observational study. International Journal of Obstetric Anesthesia, 14(2), 108–113.