Published date: Mar 03 2023

Journal Title: KnE Social Sciences

Issue title: 2nd Paris Van Java International Seminar on Health, Economics, Social Science and Humanities (PVJ-ISHESSH 2021)

Pages: 815–826

DOI: 10.18502/kss.v8i4.12977

Muhtadi .muhtadi@ums.ac.idFaculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan,Kartasura, Surakarta 57102, Indonesia

Haryoto .Faculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan,Kartasura, Surakarta 57102, Indonesia

Muthiah RabbaniyyahFaculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan,Kartasura, Surakarta 57102, Indonesia

Andi SuhendiFaculty of Pharmacy, Universitas Muhammadiyah Surakarta, Jl. A. Yani Tromol Pos I, Pabelan,Kartasura, Surakarta 57102, Indonesia

The ethanol extract of the dried fruit peels of Durio zibethinusMurr. was tested for cytotoxicity, antidiabetic, antihyperuricemia, and antihypercholesterolemia activities in experimental animals. The extract showed the potential activities of antidiabetic, antihyperuricemic, and antihypercholestrol agents. As an cytotoxicity agent, the extract was not potent against vero cells with an IC50 value of 1.864 μg/mL. Overall, Durio zibethinusMurr. fruit peels extracts had the potential to be used as an ingredient in herbal medicines for antidiabetic, antihyperuricemia and anti-hypercholesterolemia.

Keywords: herbal medicine; antidiabetic; antihyperuricemia; anti-hypercholesterolemia

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