Published date: Oct 04 2016

Journal Title: KnE Medicine

Issue title: The 6th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2016)

Pages: 7-11

DOI: 10.18502/kme.v1i1.530

Dewi Karlina Ruslyina.repromed@gmail.com

Kanadi Sumapradja

Rajuddin Rajuddin

Kartini Hasballah

Aim: To observe the effect of Dydrogesterone administration in pregnancy on PlGF level

Methods: This is a randomized controlled clinical trial. Study population has been divided into two groups. Group A consists of 20 women who receive only Folic acid 5 mg a day for 4 weeks time. Group B consists of 20 women who receive Dydrogesterone 2x10 mg a day and Folic acid 5 mg a day for 4 weeks. PlGF has been measured twice. First measurement was done before drug administration, while the second measurement has been done during 18^th weeks of pregnancy. The changes on PlGF level before and after treatment from each group has been analyzed using SPSS 17.

Results: 40 pregnant women have been recruited for this study. There are no differences based on the patient’s age, number of pregnancy and parity, gestational age and body weight between each group.  The mean levels of PlGF in both groups before intervention shows no significant difference (p = 0091 or p> 0.05), 40.80 pg/mL vs.  25.95 pg / mL. The mean levels of PlGF in group A after 4 weeks administration of Folic acid is 89.60 pg / mL. It shows the escalation of 48.8 pg / mL. The elevation of PlGF level in group A shows significant difference (p = 0.000 or p <0.05) after 4 weeks Folic acid treatment.The mean levels of PlGF in group B after 4 weeks administration of Dydrogesterone and Folic acid is 212.15 pg / mL. It shows the escalation of 186.20 pg / mL. The elevation of PlGF level in group B shows significant difference (p = 0.000 or p <0.05) after 4 weeks Dydrogesterone and Folic acid treatment.

Conclusion: Dydrogesterone treatment can increase the level of PlGF.

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