Published date: Jun 23 2023

Journal Title: KnE Medicine

Issue title: The 3rd Health Science International Conference (HSIC)

Pages: 95–105

DOI: 10.18502/kme.v3i3.13491

Dyah Rahmasaridyahrahmasari@umm.ac.idDepartment of Pharmacy, Faculty of Health Science, Muhammadiyah Malang University, Indonesia

Didin Lingga LudianaDepartment of Pharmacy, Faculty of Health Science, Muhammadiyah Malang University, Indonesia

Randy Teja PermanaDepartment of Pharmacy, Faculty of Health Science, Muhammadiyah Malang University, Indonesia

Osteoporosis is a major public health problem. Exogenous estrogen or Hormone Replacement Therapy (HRT) is the potential therapy for osteoporosis. Still, the patient rarely chooses this treatment because of the risk of breast and endometrial cancer. Phytoestrogens or estrogen-like compounds, particularly isoflavones, are a potentially safe alternative to HRT. Jicama (Pachyrhizus erosus) is a plant that contains many phytoestrogens. This research aimed to determine the physicochemical characteristics of jicama extract in effervescent tablets with various concentrations of binder and sweetener. The manufacturing of jicama effervescent tablets used raw materials extracted from 96% p.a. ethanol by maceration. The extract is then formulated with various binder concentrations (PVP 40 and gelatin) and sweeteners (lactose and Mannitol) using the wet granulation method. Based on the test results on the physicochemical properties of tablets, all the formula meets the requirement of a good tablet, and the preferred formula is Formula 4 with 0.75% of PVP40 and 47,75% Mannitol. Ethanol extract of jicama can be formulated into effervescent tablets and has the potential to be developed as a treatment for osteoporosis.

Keywords: Xicama Extract, Fitoestrogen, Estrogen-like therapy, Osteoporosis, Effervescent tablet

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