KnE Medicine

ISSN: 2519-125X

The latest conference proceedings on all fields of medicine.

Optimation of Emulgel Combination of Tea Tree Oil and Lavender Oil: Evaluation and Antibacterial Study

Published date: Mar 08 2023

Journal Title: KnE Medicine

Issue title: 2nd International Conference on Medical Health Science (2nd ICMEDH)

Pages: 518–530

DOI: 10.18502/kme.v3i2.13087

Authors:

Uswatun Chasanahuswatun@umm.ac.idPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Annisa NurwiyantiPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Agatha Salsabilla MiftakhurrohmahPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Muhammad Hamid AfifPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Zumrotun NajihahPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Rovano Rizky Hanwidi PutraPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Dyah RahmasariPharmacy Department, Health Science Faculty, University of Muhammadiyah Malang, Indonesia

Abstract:

The terpinene-4-ol contained in tea tree oil has broad-spectrum antimicrobial activity. Lavender oil contains linalool which also has antibacterial properties. So, they can be anti-acne. Both oils are formulated as emulgel hand sanitizers because this form has a better-controlled drug release effect and stability. The emulgel contained tea tree oil at 5% combined with lavender oil at 0.5%, 1%, and 2%. The evaluation consisted of physical and chemical characteristics, irritation, and antibacterial activity on skin bacteria. The results showed that each organoleptic formula had white color and a distinctive aroma of both essential oils. The texture was soft, homogeneous, and oil-in-water emulsion type; the viscosity and pH were within the specification range. All the formulas met the dispersion requirements. For the irritation test result using HET CAM methods, the preparation caused mild irritation, and the value of the irritating score increased when lavender oil levels increased. In the antibacterial test for Cutibacterium acnes, the addition of lavender oil intensified the antibacterial activity of tea tree oil. On the other hand, an antibacterial test for Staphylococcus aureus and Staphylococcus epidermis of lavender oil added to tea tree oil does not influence the antibacterial activity of tea tree oil in emulgel preparation.

Keywords: emulgel of combination tea tree oil and lavender oil, characteristic, irritation effect, antibacterial property

References:

[1] Hadianti S, Sastypratiwi H, Sukamto AS. Sistem Pakar Diagnosis Jenis Jerawat Pada Wajah Menggunakan Metode K-Means Clustering. J. Sist. Dan Teknol. Inf. 2015;3(3):1–5.

[2] Sawarkar, Khadabadi, Mankar, Farooqui, and Jagtap, “Development and Biological Evaluation of Herbal Anti_Acne Gel,”. Pham Tech. 2010;2(3):2028–31.

[3] Totté JE, van der Feltz WT, Bode LG, van Belkum A, van Zuuren EJ, Pasmans SG. A systematic review and meta-analysis on Staphylococcus aureus carriage in psoriasis, acne and rosacea. Eur J Clin Microbiol Infect Dis. 2016 Jul;35(7):1069–77.

[4] Claudel JP, Auffret N, Leccia MT, Poli F, Corvec S, Dréno B. Staphylococcus epidermidis: A Potential New Player in the Physiopathology of Acne? Dermatology. 2019;235(4):287–94.

[5] Lee CJ, Chen LW, Chen LG, Chang TL, Huang CW, Huang MC, et al. Correlations of the components of tea tree oil with its antibacterial effects and skin irritation. J Food Drug Anal. 2013;21(2):169–76.

[6] Pazyar N, Yaghoobi R, Bagherani N, Kazerouni A. A review of applications of tea tree oil in dermatology. Int J Dermatol. 2013 Jul;52(7):784–90.

[7] Ahmad S, Popli H. A review on efficacy and tolerability of tea tree oil for acne. J Drug Deliv Ther. 2019;9(3):609–12.

[8] Cavanagh HM, Wilkinson JM. Lavender essential oil: a review. Aust Infect Control. 2005;10(1):35–7.

[9] Kwiatkowski P, Łopusiewicz Ł, Kostek M, Drozłowska E, Pruss A, Wojciuk B, et al. The antibacterial activity of lavender essential oil alone and in combination with octenidine Dihydrochloride against MRSA strains. Molecules. 2019 Dec;25(1):95.

[10] Sah SK, Badola A, Nayak BK. Emulgel: magnifying the application of topical drug delivery. Indian J. Pharm. Biol. Res. 2017;5(01):25–33.

[11] Phad AR, Dilip NT, Ganapathy S. Emulgel : A Comprehensive Review for. Asian J Pharm. 2018;2018(2):6–12.

[12] Yenti R, Afrianti R, Qomariah S. Ekstrak Etanol Daun Dewa (Gynura pseudochina (L.) DC) Untuk Pengobatan Nyeri Sendi Terhadap Tikus Putih Jantan. Pros. Semin. Nas. dan Work. 2014.

[13] S. A. Mardikasari, A. N. T. A. Mallarangeng, W. O. S. Zubaydah, E. Juswita. Uji Stabilitas Lotion dari Ekstrak Etanol Daun Jambu Biji (Psidium guajava L.). J. Farm. Sains, dan Kesehat. 2017;3(2):28-32.

[14] E. Rustiani, S. Andini, M. Apriani. Formulasi Sediaan Emulgel Ekatrak Etanol 70 % Daun Talas (Colocasia esculenta (L.) Schott) Dengan Variasi Konsentrasi Karbopol 940. 2021.

[15] Garg A, Aggarwal D, Garg S, Singla AK. Spreading of semisolid formulations: an update. Pharm Technol N Am. 2002.

[16] Rieger MM. “Emulsions,” Theory Pract. Ind.: Pharm; 1978. pp. 502–33.

[17] Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). “Recommended Test Method Protocol : Hen ’ s Egg Test – Chorioallantoic Membrane (HET-CAM) Test Method,” ICCVAM In Vitro Ocular Evaluation Report. 2010;13(10);B30-B38.

[18] Aho, J., Hvidt,S., and Baldursdottir,S. Rheology in Pharmaceutical Sciences. Advances in Delivery Science and Technology book series (ADST). Springer, New York. 2016. https://doi.org/10.1007/978-1-4939-4029-5_23.

[19] Swedish Chemicals Agency. CLH Report for Linalool. Propos. Harmon. Classfication Label. 2014;2014(1272):1–159.

[20] Lai-Cheong JE, McGrath JA. Structure and function of skin, hair and nails. Medicine (Abingdon). 2017;45(6):347–51.

[21] Hudaiva RA. Gambaran Pengetahuan Tentang Konjungtivitis Pada Mahasiswa Fakultas Teknik Jurusan Teknik Mesin Universitas Jember. Digit. Repos. Univ. Jember. 2021;2019–2022,.

[22] Reis Mansur MC, Leitão SG, Cerqueira-Coutinho C, Vermelho AB, Silva RS, Presgrave OA, et al. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Rev Bras Farmacogn. 2016;26(2):251–8.

[23] Orchard A, van Vuuren S. Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases. Evid Based Complement Alternat Med. 2017;2017:4517971.

[24] Bassolé IH, Juliani HR. Essential oils in combination and their antimicrobial properties. Molecules. 2012 Apr;17(4):3989–4006.

[25] Stockley K, Williams L, Yan W, Home V. Essential Oils With for Activity Therapeutic Use. Int. J. Aromather. 1998;8(4):30–40.

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