Published date: Sep 11 2017

Journal Title: KnE Life Sciences

Issue title: International Conference on Natural Resources and Life Sciences (NRLS-2016)

Pages: 202-207

DOI: 10.18502/kls.v3i5.994

Sri WahjuniSriWahjunisriwahjunimanuaba@gmail.comFaculty of Mathematics and Natural Science, Udayana University,Campus Udayana University Street, 80361 Bukit Jimbaran, Bali, Indonesia

Anak Agung Istri Ayu Mayun Laksmiwati

Ni Made Puspawati

Stress oxidative can cause the development of pathological condition such as diabetes mellitus.  Garcinia mangostana L., locally known as “Manggis” is a tropical fruit rich in polyphenolic compounds that possesses high antioxidant activity.  This research aimed to study the effect of intake pericarp G. mangostana ethanol extract in inhibiting stress oxidative in hyperglycemic Wistar rats by analyzing superoxide dismutase (SOD) activity and histopathology of pancreatic cell. Extraction of 800 g pericarp Garcinia mangostana with ethanol gave 147 g crude ethanol extract. Hyperglycemic on Wistar rats was made by inducing hyperglycemic with alloxan. The experimental was performed on five groups of animals that were Hyperglycemic. The dose of pericarp of Garcinia extract given to of rats which assigned P₀ for normal control, P₁ for negative control (hyperglycaemic), P₂  for hyperglycemic rats with Garcinia extract 50 mg · kg^-1 body weight; P₃ for hyperglycemia rats treated with  100 mg · kg^–1 body weight and P₄ treated  with  150 mg · kg^–1 body weight. The result showed that intake of pericarp Garcinia extract in all dose given have increased the activity of superoxide dismutase (SOD). The highest SOD activity was obtained in P₄ with given  of 150 mg · kg^–1 body weight and SOD activity increased to 65.71 %. The increased of SOD activity was directly proportional to the histopathology profile of pancreatic found in the hyperglycemic rat.

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